To Recognize the importance of clinical, laboratory, and morphologic manifestations of glomerular diseases of the kidneys to enhance skills in diagnostic and prognostic evaluation of these disorders.
To Discuss and interpret the potential pathogenetic mechanisms that underlie primary and secondary forms of glomerular diseases.
To Describe the rationale, efficacy, and safety of current and emerging therapeutic approaches to primary and secondary glomerular diseases of the kidneys.
ASN is responsible for identifying and resolving all conflicts of interest prior to presenting any educational activity to learners to ensure that ASN CME activities promote quality and safety, are effective in improving medical practice, are based on valid content, and are independent of the control from commercial interests and free of bias. All faculty are instructed to provide balanced, scientifically rigorous and evidence-based presentations. In accordance with the disclosure policies of the Accreditation Council for Continuing Medical Education (ACCME), individuals who are in a position to control the content of an educational activity are required to disclose relationships with a commercial interest if (a) the relation is financial and occurred within the past 12 months; and (b) the individual had the opportunity to affect the content of continuing medical education with regard to that commercial interest. For this purpose, ASN consider the relationships of the person involved in the CME activity to include financial relationships of a spouse or partner. Peer reviewers are asked to abstain from reviewing topics if they have a conflict of interest. Disclosure information is made available to learners prior to the start of any ASN educational activity.
Alice M. Sheridan, MD—Current Employer: Brigham and Women’s Hospital
Martina M. McGrath, MBChB, FASN—Current Employer: Brigham and Women’s Hospital; VA Boston Medical Center
Daniel C. Cattran, MD—Current Employer: Toronto General Hospital; Consultancy Agreements: Chemocentryx, Calliditis, Alnylam, Principia; Research Funding: Chemocentryx, Alnylam; Honoraria: Principia, Calliditis, Kyowa Hakko Kirin Co; Scientific Advisor or Membership: UpToDate, NephCure, SONG-GD
Wooin Ahn, MD—Current Employer: Columbia University
Gaia M. Coppock, MD—Current Employer: University of Pennsylvania
Frank B. Cortazar, MD—Current Employer: New York Nephrology Vasculitis and Glomerular Center; Consultancy Agreements: ChemoCentryx, Retrophin; Honoraria: ChemoCentryx, Retrophin
Fernando C. Fervenza, MD, PhD, FASN—Current Employer: Mayo Clinic; Consultancy Agreements: Alexion Pharmaceuticals, Alnylam, ByoCrystal; Research Funding: Genentech, Questcor/Mallinckrodt, Janssen Pharmaceutical, Chemocentryx; Honoraria: UpToDate; Scientific Advisor or Membership: UpToDate, Kidney International, Nephrology, Nephrology Dialysis and Transplantation, JASN
Ali G. Gharavi, MD—Current Employer: Columbia University; Consultancy Agreements: AstraZeneca Center for Genomics Research, Goldfinch Bio; Research Funding: Renal Research Institute; Honoraria: Sanofi; Scientific Advisor or Membership: JASN Editoral Board, Kidney International, and Journal of Nephrology
Jonathan J. Hogan, MD—Current Employer: University of Pennsylvania; Consultancy Agreements: Retrophin; Research Funding: Retrophinsite PI for DUET and DUPLEX Studies in FSGS, Achillionsite PI for clinical trial in C3G, Omerossite PI for clinical trial in IgA nephropathy, Complexasite PI for clinical trial in FSGS, Calliditassite PI for clinical trial in IgA nephropathy, Regeneron, Gilead, GSK, Boeringer IngelheimTRIDENT study for diabetic nephropathy; Honoraria: Dimerix; Zyversa; Goldfinch Bio, GSK, Retrophin, Alexion; Patents and Inventions: royalties for patent (pending) as co-inventor; WO2019213434A1; Scientific Advisor or Membership: Zyversa (Advisory board); Other Interests/Relationships: UpToDateauthor with royalties for topics on calcium/phosphorous balance and MGRS
Matthew B. Lanktree, MD, PhD—Current Employer: St. Joseph Healthcare Hamilton; McMaster University; Research Funding: KRESCENT Program Young Investigator (Kidney Foundation of Canada, Canadian Society of Nephrology, Canadian Institutes of Health Research), grant funding from Canadian Institutes of Health Research, Hamilton Health Sciences, and Hamilton Academic Health Sciences Organization (HAHSO); Honoraria: Otsuka Pharmaceuticals; Scientific Advisor or Membership: M.B.L. received compensation for participating in advisory and consultancy boards with Otsuka pharmaceuticals
Stephen Paul McAdoo, MA, MBBS, PhD—Current Employer: Imperial College London; Consultancy Agreements: GSK; Honoraria: Rigel Pharmaceuticals, ThermoFisher Scientific, Celltrion
Susanne B. Nicholas, MD, PhD, MPH—Current Employer: David Geffen School of Medicine at UCLA; Consultancy Agreements: Janssen Pharmaceutical, Bayer, Goldfinch, GeorgeClinical, Boehringer Ingelheim Pharmaceutical; Research Funding: NIH/NIMHD, Center for Disease Prevention and Control, Terasaki Institute of Innovation, Goldfinch Bio; Honoraria: NIH/NIDDK Grant Review Study Sections, Reviewer: American Diabetes Association; Patents and Inventions: Provisional Patent: Novel Small Molecule Drug to Treat Diabetic Kidney Disease; Scientific Advisor or Membership: National Kidney Foundation of Southern California and Southern Nevada Board of Directors and Medical Advisory Board Executive Committee, American Society of Hypertension Hypertension Specialist Advisory Board, Janssen Pharmaceutical, Boehringer Ingelheim; Speaker's Bureau: Janssen Pharmaecutical
Kathleen M. Nicholls, MD, MBBS—Current Employer: Royal Melbourne Hospital; Consultancy Agreements: Small temporary Consultancy Agreements with Shire, Amicus and Genzyme-Sanofi sponsored meetings; Research Funding: Current - Shire HGT, Genzyme-Sanofi investigator research grants, Active clinical/registry research support from Shire HGT, Genzyme-Sanofi, Amicus Therapeutics, Avrobio and Idorsia; Honoraria: Shire HGT, Genzyme-Sanofi, Amicus Therapeutics; Scientific Advisor or Membership: Fabry Outcome Study (FOS) - International Advisory Board (Honorary), and Amicus Follow me registry International Advisory Board, Australian Fabry Advisory Boards: Shire HGT, Amicus and Genzyme-Sanofi; Other Interests/Relationships: Fabry Australia Medical Advisory Group (patient support group, honorary)
York P. Pei, MD, FASN—Current Employer: University Health Network and University of Toronto; Consultancy Agreements: Otsuka, Sanofi, Vertex; Honoraria: Otsuka, Sanofi, Vertex; Scientific Advisor or Membership: Steering committee for a RCT in ADPKD (Sanofi/Genzyme)
Charles D. Pusey, MD, FASN—Current Employer: Imperial College London; Ownership Interest: Cell Medica; Research Funding: Kidney Research UK, Imperial Health Charity, Vasculitis UK; Honoraria: Med Update Europe; Scientific Advisor or Membership: Editorial boards - JASN, Nephrology Dialysis Transplantation, CJASN
Meghan E. Sise, MD, MS—Current Employer: Massachusetts General Hospital; Consultancy Agreements: Bioporto; Research Funding: Gilead Sciences, AbbVie, Merck, EMD-Serono; Honoraria: International Society of Hemodialysis - Hemodialysis University Lecture; Scientific Advisor or Membership: Gilead Sciences
Katherine R. Tuttle, MD, FASN—Current Employer: Providence Health Care, University of Washington School of Medicine; Consultancy Agreements: Eli Lilly, Boehringer Ingelheim, Gilead, AstraZeneca, Goldfinch Bio, Novo Nordisk, Bayer, Janssen; Research Funding: Goldfinch Bio, Bayer; Scientific Advisor or Membership: CJASN, NIDDK, Kidney Health Initiative
Ladan Zand, MD—Current Employer: University of Minnesota; Research Funding: Mallinckrodt, Janssen Pharmaceuticals, Genentech
Reza Zonozi, MD—Current Employer: Massachusetts General Hospital
There is no commercial support for this issue.
The nephSAP editorial team and the KSAP editorial board extend their sincere appreciation to the following reviewers. Their efforts and insights help improve the quality of these postgraduate education offerings.
nephSAP Review Panel
Mustafa Ahmad, MD, FASN, King Fahad Medical City, Riyadh, Saudi Arabia
Dario Roccatello, MD, San Giovanni Hospital and University of Torino, Torino, Italy
Helbert Rondon-Berrios, MD, FASN, University of Pittsburgh School of Medicine, Pittsburgh, PA
Ehab R. Saad, MD, FASN, Medical College of Wisconsin, Milwaukee, WI
Mark C. Saddler, MBChB, Mercy Regional Medical Center, Durango, CO
Neil Sanghani, MD, Vanderbilt University, Nashville, TN
Mohammad N. Saqib, MD, Lehigh Valley Hospital, Allentown, PA
Hitesh H. Shah, MD, Hofstra Northwell School of Medicine, Great Neck, NY
Michiko Shimada, MD, PhD, Hirosaki University, Hirosaki, Japan
Shayan Shirazian, MD, Winthrop-University Hospital State University of New York at Stony Brook, Mineola, NY
Arif Showkat, MD, FASN, University of Tennessee, Memphis, TN
Stephen M. Sozio, MD, Johns Hopkins University School of Medicine, Baltimore, MD
Ignatius Yun-Sang Tang, MD, FASN, University of Illinois at Chicago, Chicago, IL
Ahmad R. Tarakji, MD, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia
Hung-Bin Tsai, MD, National Taiwan University, Taipei, Taiwan
Katherine Twombley, MD, Medical University of South Carolina, Charleston, SC
Kausik Umanath, MD, Henry Ford Hospital, Detroit, MI
Puchimada M. Uthappa, MBBS, FASN, Columbia Asia Hospital, Mysore, Karnataka, India
Anthony M. Valeri, MD, Columbia University Medical Center, New York, NY
Allen W. Vander, MD, FASN, Kidney Center of South Louisiana, Thibodaux, LA
Jon R. Von Visger, MD, PhD, The Ohio State University, Columbus, OH
Nand K. Wadhwa, MD, Stony Brook University, Stony Brook, NY
Connie Wang, MD, Hennepin County Medical Center, Minneapolis, MN
Maura A. Watson, DO, Walter Reed National Military Medical Center, Bethesda, MD
Dawn Wolfgram, MD, Medical College of Wisconsin, Milwaukee, WI
Sri Yarlagadda, MBBS, University of Kansas Medical Center, Kansas City, KS
Brian Young, MD, Santa Clara Valley Medical Center, San Jose, CA
Mario Javier Zarama, MD, Kidney Specialists of Minnesota, Saint Paul, MN
Program Mission and Objectives
nephSAP® provides a learning vehicle for physicians, scientists, advanced practitioners, nurses, pharmacists, and other health professionals working and training in the field of nephrology to renew and refresh their clinical knowledge, diagnostic, and therapeutic skills. This enduring material provides learners challenging, clinically-oriented questions based on case vignettes, detailed learning objectives, a series of articles that review recent publications, and an editorial on an important and evolving topic. This combination of materials enables learners to rigorously assess their strengths and weaknesses in the broad domain of nephrology.
Physicians, scientists, advanced practitioners, nurses, pharmacists, and other health professionals working and training in the field of nephrology.
Accreditation and AMA Credit Designation Statements
In support of improving patient care, the American Society of Nephrology is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
The American Society of Nephrology designates this internet activity (enduring material) for a maximum of 10.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
ABIM MOC Statement
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 10.0MOCpoints in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. MOC points will be applied to only those ABIM candidates who have enrolled in the MOC program. It is your responsibility to complete the ABIM MOC enrollment process.
Original Release Date: October 2020
CME/MOC Termination Date: September 30, 2022
Examination Available Online: On or before October 30, 2020
Estimated Time for Completion: 10 hours
Answers with explanations are provided with a passing score after the first and/or second attempt
This issue will be archived in September 2022, and answers with explanations will be posted on the ASN website
Method of Participation
Read the entire issue that is supplemented by original articles in the reference lists.
Complete the online self-assessment examination.
Each participant is allowed two attempts to pass the examination (75% correct) for CME and MOC.
Upon completion, review your score and incorrect answers and print your certificate.
Activity Evaluation, CME and MOC
Go to ASN CME Center (www.asn-online.org/cme), and log in.
Click the ENTER ACTIVITY button for this issue.
Read all frontmatter information.
Under the To Do List on the left navigation:
Click the Demographics & General Eval link, and enter your information.
If you are a physician:
Complete the Exam (required for CME/MOC). Physicians participating in this activity will be given two (2) attempts to pass the Exam (minimum performance level = 75% correct). Upon completion, you wil be able to access the Answers and Explanations for viewing. If you do not pass the Post Test within 2 attempts, you cannot claim CME/MOC for this activity.
Click the Claim Your CME Credits link, check the Attestation Statement box, and submit.
Click the Claim Your MOC Points link (for ABIM Diplomates only), check the Attestation Statement box, and submit.
Click the Print Your Certificate link.
For your complete ASN transcript, click the ASN CME Center banner, and click View/Print Transcript on the left.
Instructions to obtain American Board of Internal Medicine (ABIM) Maintenance of Certiﬁcation (MOC) Points
Each issue of nephSAP provides 10 MOC points. Respondents must meet the following criteria:
Be certiﬁed by ABIM in internal medicine and/or nephrology and enrolled in the ABIM–MOC program...
Enter your (ABIM) Candidate Number and Date of Birth prior to completing the examination.
Take the self-assessment examination within the timeframe speciﬁed in this issue of nephSAP.
Upon completion, click Claim Your MOC points, the MOC points submitted will match your CME credits claimed, check the Attestation Statement box and submit.
ABIM will notify you when MOC points have been added to your record.
ABIM MOC Statement
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 10.0 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certiﬁcation (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to Joint Accreditation for the purpose of granting ABIM MOC credit.
MOC points will be applied to only those ABIM candidates who have enrolled in the MOC program. It is your responsibility to complete the ABIM MOC enrollment process.
System Requirements Compatible Browser and Software
The nephSAP website (nephsap.org) is formatted for cross-browser functionality, and should display correctly in all currently supported web browsers. Individual nephSAP articles are available as dynamic HTML or in Portable Document Format (PDF), which requires Adobe Reader or comparable PDF viewing software.
The nephSAP website is designed for responsive display. This means the content display will respond to the device you use and to your devices screen resolution.
Medium or Combination of Media Used
The media used include content provided online as dynamic HTML or downloadable PDF, in addition to an online evaluation and self-assessment examination.
If you have difficulty viewing any of the pages, please refer to the nephSAP technical support page for possible solutions. If you continue having problems, contact ASN at email@example.com.