MagnussenC, OjedaFM, LeongDP, Alegre-DiazJ, AmouyelP, Aviles-SantaL, et al.; Global Cardiovascular Risk Consortium: Global effect of modifiable risk factors on cardiovascular disease and mortality. N Engl J Med389: 1273–1285, 202310.1056/NEJMoa2206916PubMed
MagnussenC, OjedaFM, LeongDP, Alegre-DiazJ, AmouyelP, Aviles-SantaL, ; Global Cardiovascular Risk Consortium: Global effect of modifiable risk factors on cardiovascular disease and mortality. N Engl J Med 389: 1273–1285, 202310.1056/NEJMoa2206916PubMed)| false
GarofaloC, BorrelliS, PacilioM, MinutoloR, ChiodiniP, De NicolaL, et al.: Hypertension and prehypertension and prediction of development of decreased estimated GFR in the general population: A meta-analysis of cohort studies. Am J Kidney Dis67: 89–97, 201610.1053/j.ajkd.2015.08.027PubMed
GarofaloC, BorrelliS, PacilioM, MinutoloR, ChiodiniP, De NicolaL, : Hypertension and prehypertension and prediction of development of decreased estimated GFR in the general population: A meta-analysis of cohort studies. Am J Kidney Dis 67: 89–97, 201610.1053/j.ajkd.2015.08.027PubMed)| false
DoumasM, TsioufisC, FletcherR, AmdurR, FaselisC, PapademetriouV: Time in therapeutic range, as a determinant of all-cause mortality in patients with hypertension. J Am Heart Assoc6: e007131, 201710.1161/JAHA.117.007131PubMed
DoumasM, TsioufisC, FletcherR, AmdurR, FaselisC, PapademetriouV: Time in therapeutic range, as a determinant of all-cause mortality in patients with hypertension. J Am Heart Assoc 6: e007131, 201710.1161/JAHA.117.007131PubMed)| false
HardyST, JaegerBC, FotiK, GhaziL, WozniakG, MuntnerP: Trends in blood pressure control in US adults with hypertension, 2013–2014 to 2021–2023. Am J Hypertens38: hpae141, 202410.1093/ajh/hpae141PubMed
HardyST, JaegerBC, FotiK, GhaziL, WozniakG, MuntnerP: Trends in blood pressure control in US adults with hypertension, 2013–2014 to 2021–2023. Am J Hypertens 38: hpae141, 202410.1093/ajh/hpae141PubMed)| false
FryarCD, KitB, CarrollMD, AffulJ: Hypertension prevalence, awareness, treatment, and control among adults age 18 and older: United States, August 2021–August 2023. NCHS Data Brief 511, Hyattsville, MD, National Center for Health Statistics, 202410.15620/cdc/164016
FryarCD, KitB, CarrollMD, AffulJ: Hypertension prevalence, awareness, treatment, and control among adults age 18 and older: United States, August 2021–August 2023. NCHS Data Brief 511, Hyattsville, MD, National Center for Health Statistics, 202410.15620/cdc/164016)| false
EbingerJE, GluckmanTJ, MagranerJ, ChiuST, RiderD, ThomasC, et al.: Characterization of individuals with apparent resistant hypertension using contemporary guidelines: Insights from CV-QUIC. Hypertension80: 1845–1855, 202310.1161/HYPERTENSIONAHA.123.20894PubMed
HolmesHR, LiQ, XuK, KimS, RichardsEM, KeeleyEC, et al.: Antihypertensive medication adherence trends by sex and drug class: A pilot study. Am Heart J Plus5: 100023, 202110.1016/j.ahjo.2021.100023PubMed
HolmesHR, LiQ, XuK, KimS, RichardsEM, KeeleyEC, : Antihypertensive medication adherence trends by sex and drug class: A pilot study. Am Heart J Plus 5: 100023, 202110.1016/j.ahjo.2021.100023PubMed)| false
HuguetN, GreenBB, VossRW, LarsonAE, AngierH, MiguelM, et al.: Factors associated with blood pressure control among patients in community health centers. Am J Prev Med64: 631–641, 202310.1016/j.amepre.2022.11.002PubMed
HuguetN, GreenBB, VossRW, LarsonAE, AngierH, MiguelM, : Factors associated with blood pressure control among patients in community health centers. Am J Prev Med 64: 631–641, 202310.1016/j.amepre.2022.11.002PubMed)| false
BerglandOU, HalvorsenLV, SøraasCL, HjørnholmU, KjærVN, RognstadS, et al.: Detection of nonadherence to antihypertensive treatment by measurements of serum drug concentrations. Hypertension78: 617–628, 202110.1161/HYPERTENSIONAHA.121.17514PubMed
BerglandOU, HalvorsenLV, SøraasCL, HjørnholmU, KjærVN, RognstadS, : Detection of nonadherence to antihypertensive treatment by measurements of serum drug concentrations. Hypertension 78: 617–628, 202110.1161/HYPERTENSIONAHA.121.17514PubMed)| false
JosephJJ, PohlmanNK, ZhaoS, KlineD, BrockG, Echouffo-TcheuguiJB, et al.: Association of serum aldosterone and plasma renin activity with ambulatory blood pressure in African Americans: The Jackson Heart Study. Circulation143: 2355–2366, 202110.1161/CIRCULATIONAHA.120.050896PubMed
JosephJJ, PohlmanNK, ZhaoS, KlineD, BrockG, Echouffo-TcheuguiJB, : Association of serum aldosterone and plasma renin activity with ambulatory blood pressure in African Americans: The Jackson Heart Study. Circulation 143: 2355–2366, 202110.1161/CIRCULATIONAHA.120.050896PubMed)| false
JędrusikP, SymonidesB, LewandowskiJ, GaciongZ: The effect of antihypertensive medications on testing for primary aldosteronism. Front Pharmacol12: 684111, 202110.3389/fphar.2021.684111PubMed
JędrusikP, SymonidesB, LewandowskiJ, GaciongZ: The effect of antihypertensive medications on testing for primary aldosteronism. Front Pharmacol 12: 684111, 202110.3389/fphar.2021.684111PubMed)| false
Te RietL, van EschJH, RoksAJ, van den MeirackerAH, DanserAH: Hypertension: Renin-angiotensin-aldosterone system alterations. Circ Res116: 960–975, 201510.1161/CIRCRESAHA.116.303587PubMed
Te RietL, van EschJH, RoksAJ, van den MeirackerAH, DanserAH: Hypertension: Renin-angiotensin-aldosterone system alterations. Circ Res 116: 960–975, 201510.1161/CIRCRESAHA.116.303587PubMed)| false
TeixeiraLB, Parreiras-E-SilvaLT, Bruder-NascimentoT, DuarteDA, SimõesSC, CostaRM, et al.: Ang-(1-7) is an endogenous beta-arrestin-biased agonist of the AT(1) receptor with protective action in cardiac hypertrophy. Sci Rep7: 11903, 201710.1038/s41598-017-12074-3PubMed
TeixeiraLB, Parreiras-E-SilvaLT, Bruder-NascimentoT, DuarteDA, SimõesSC, CostaRM, : Ang-(1-7) is an endogenous beta-arrestin-biased agonist of the AT(1) receptor with protective action in cardiac hypertrophy. Sci Rep 7: 11903, 201710.1038/s41598-017-12074-3PubMed)| false
RanjitA, KhajehpourS, Aghazadeh-HabashiA: Update on angiotensin II subtype 2 receptor: Focus on peptide and nonpeptide agonists. Mol Pharmacol99: 469–487, 202110.1124/molpharm.121.000236PubMed
MesserliFH, BangaloreS, BavishiC, RimoldiSF: Angiotensin-converting enzyme inhibitors in hypertension: To use or not to use?J Am Coll Cardiol71: 1474–1482, 201810.1016/j.jacc.2018.01.058PubMed
MesserliFH, BangaloreS, BavishiC, RimoldiSF: Angiotensin-converting enzyme inhibitors in hypertension: To use or not to use?J Am Coll Cardiol 71: 1474–1482, 201810.1016/j.jacc.2018.01.058PubMed)| false
PazMA, de-La-SierraA, SáezM, BarcelóMA, RodríguezJJ, CastroS, et al.: Treatment efficacy of anti-hypertensive drugs in monotherapy or combination: ATOM systematic review and meta-analysis of randomized clinical trials according to PRISMA statement. Medicine (Baltimore)95: e4071, 201610.1097/MD.0000000000004071PubMed
PazMA, de-La-SierraA, SáezM, BarcelóMA, RodríguezJJ, CastroS, : Treatment efficacy of anti-hypertensive drugs in monotherapy or combination: ATOM systematic review and meta-analysis of randomized clinical trials according to PRISMA statement. Medicine (Baltimore) 95: e4071, 201610.1097/MD.0000000000004071PubMed)| false
TakahashiS, KatadaJ, DaidaH, KitamuraF, YokoyamaK: Effects of mineralocorticoid receptor antagonists in patients with hypertension and diabetes mellitus: A systematic review and meta-analysis. J Hum Hypertens30: 534–542, 201610.1038/jhh.2015.119PubMed
TakahashiS, KatadaJ, DaidaH, KitamuraF, YokoyamaK: Effects of mineralocorticoid receptor antagonists in patients with hypertension and diabetes mellitus: A systematic review and meta-analysis. J Hum Hypertens 30: 534–542, 201610.1038/jhh.2015.119PubMed)| false
DreierR, AndersenUB, FormanJL, SheykhzadeM, EgfjordM, JeppesenJL: Effect of increased potassium intake on adrenal cortical and cardiovascular responses to angiotensin II: A randomized crossover study. J Am Heart Assoc10: e018716, 202110.1161/JAHA.120.018716PubMed
HoornEJ, GritterM, CuevasCA, FentonRA: Regulation of the renal NaCl cotransporter and its role in potassium homeostasis. Physiol Rev100: 321–356, 202010.1152/physrev.00044.2018PubMed
HoornEJ, GritterM, CuevasCA, FentonRA: Regulation of the renal NaCl cotransporter and its role in potassium homeostasis. Physiol Rev 100: 321–356, 202010.1152/physrev.00044.2018PubMed)| false
BurnierM: Should we eat more potassium to better control blood pressure in hypertension?Nephrol Dial Transplant34: 184–193, 201910.1093/ndt/gfx340PubMed
BurnierM: Should we eat more potassium to better control blood pressure in hypertension?Nephrol Dial Transplant 34: 184–193, 201910.1093/ndt/gfx340PubMed)| false
ErnstME, FravelMA: Thiazide and the thiazide-like diuretics: Review of hydrochlorothiazide, chlorthalidone, and indapamide. Am J Hypertens35: 573–586, 202210.1093/ajh/hpac048PubMed
ErnstME, FravelMA: Thiazide and the thiazide-like diuretics: Review of hydrochlorothiazide, chlorthalidone, and indapamide. Am J Hypertens 35: 573–586, 202210.1093/ajh/hpac048PubMed)| false
GrimmPR, Lazo-FernandezY, DelpireE, WallSM, DorseySG, WeinmanEJ, et al.: Integrated compensatory network is activated in the absence of NCC phosphorylation. J Clin Invest125: 2136–2150, 201510.1172/JCI78558PubMed
WangB, WenD, LiH, Wang-FranceJ, SansomSC: Net K+ secretion in the thick ascending limb of mice on a low-Na, high-K diet. Kidney Int92: 864–875, 201710.1016/j.kint.2017.04.009PubMed
WangB, WenD, LiH, Wang-FranceJ, SansomSC: Net K+ secretion in the thick ascending limb of mice on a low-Na, high-K diet. Kidney Int 92: 864–875, 201710.1016/j.kint.2017.04.009PubMed)| false
BalasubramanianP, HallD, SubramanianM: Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases. Geroscience41: 13–24, 201910.1007/s11357-018-0048-5PubMed
BalasubramanianP, HallD, SubramanianM: Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases. Geroscience 41: 13–24, 201910.1007/s11357-018-0048-5PubMed)| false
HeringL, RahmanM, PotthoffSA, RumpLC, StegbauerJ: Role of α2-adrenoceptors in hypertension: Focus on renal sympathetic neurotransmitter release, inflammation, and sodium homeostasis. Front Physiol11: 566871, 202010.3389/fphys.2020.566871PubMed
HeringL, RahmanM, PotthoffSA, RumpLC, StegbauerJ: Role of α2-adrenoceptors in hypertension: Focus on renal sympathetic neurotransmitter release, inflammation, and sodium homeostasis. Front Physiol 11: 566871, 202010.3389/fphys.2020.566871PubMed)| false
VerweijP, DanaietashP, FlamionB, MenardJ, BelletM: Randomized dose-response study of the new dual endothelin receptor antagonist aprocitentan in hypertension. Hypertension75: 956–965, 202010.1161/HYPERTENSIONAHA.119.14504PubMed
VerweijP, DanaietashP, FlamionB, MenardJ, BelletM: Randomized dose-response study of the new dual endothelin receptor antagonist aprocitentan in hypertension. Hypertension 75: 956–965, 202010.1161/HYPERTENSIONAHA.119.14504PubMed)| false
KrumH, ViskoperRJ, LacourciereY, BuddeM, CharlonV: The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators. N Engl J Med338: 784–790, 199810.1056/NEJM199803193381202PubMed
KrumH, ViskoperRJ, LacourciereY, BuddeM, CharlonV: The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators. N Engl J Med 338: 784–790, 199810.1056/NEJM199803193381202PubMed)| false
WeberMA, BlackH, BakrisG, KrumH, LinasS, WeissR, et al.: A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: A randomised, double-blind, placebo-controlled trial. Lancet374: 1423–1431, 200910.1016/S0140-6736(09)61500-2PubMed
BakrisGL, LindholmLH, BlackHR, KrumH, LinasS, LinsemanJV, et al.: Divergent results using clinic and ambulatory blood pressures: Report of a darusentan-resistant hypertension trial. Hypertension56: 824–830, 201010.1161/HYPERTENSIONAHA.110.156976PubMed
Food and Drug Administration: Highlights of prescribing information: TRYVIOTM (aprocitentan) tablets, for oral use. Initial U.S. approval: 2024. Revised March 2024. Available at https://www.fda.gov/drugsatfda. Accessed April 6, 2025.
Food and Drug Administration: Highlights of prescribing information: TRYVIOTM (aprocitentan) tablets, for oral use. Initial U.S. approval: 2024. Revised March 2024. Available at https://www.fda.gov/drugsatfda. Accessed April 6, 2025.)| false
MaddoxTM, JanuzziJL, AllenLA, BreathettK, ButlerJ, DavisLLJr., et al.; Writing Committee: 2021 update to the 2017 ACC expert consensus decision pathway for optimization of heart failure treatment: Answers to 10 pivotal issues about heart failure with reduced ejection fraction: A report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol77: 772–810, 202110.1016/j.jacc.2020.11.022PubMed
MaddoxTM, JanuzziJL, AllenLA, BreathettK, ButlerJ, DavisLLJr., ; Writing Committee: 2021 update to the 2017 ACC expert consensus decision pathway for optimization of heart failure treatment: Answers to 10 pivotal issues about heart failure with reduced ejection fraction: A report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol 77: 772–810, 202110.1016/j.jacc.2020.11.022PubMed)| false
JacksonAM, JhundPS, AnandIS, DüngenH-D, LamCSP, LefkowitzMP, et al.: Sacubitril-valsartan as a treatment for apparent resistant hypertension in patients with heart failure and preserved ejection fraction. Eur Heart J42: 3741–3752, 202110.1093/eurheartj/ehab499PubMed
RakugiH, KarioK, YamaguchiM, SasajimaT, GotouH, ZhangJ: Efficacy of sacubitril/valsartan versus olmesartan in Japanese patients with essential hypertension: A randomized, double-blind, multicenter study. Hypertens Res45: 824–833, 202210.1038/s41440-021-00819-7PubMed
RakugiH, KarioK, YamaguchiM, SasajimaT, GotouH, ZhangJ: Efficacy of sacubitril/valsartan versus olmesartan in Japanese patients with essential hypertension: A randomized, double-blind, multicenter study. Hypertens Res 45: 824–833, 202210.1038/s41440-021-00819-7PubMed)| false
WangB, WangG-H, DingX-X, TangH-X, ZhengJ, LiuB-C, et al.: Effects of Sacubitril/Valsartan on resistant hypertension and myocardial work in hemodialysis patients. J Clin Hypertens (Greenwich)24: 300–308, 202210.1111/jch.14422PubMed
KarioK, RakugiH, YarimizuD, MoritaY, EguchiS, IekushiK: Twenty-four-hour blood pressure-lowering efficacy of sacubitril/valsartan versus olmesartan in Japanese patients with essential hypertension based on nocturnal blood pressure dipping status: A post hoc analysis of data from a randomized, double-blind multicenter study. J Am Heart Assoc12: e027612, 202310.1161/JAHA.122.027612PubMed
KarioK, RakugiH, YarimizuD, MoritaY, EguchiS, IekushiK: Twenty-four-hour blood pressure-lowering efficacy of sacubitril/valsartan versus olmesartan in Japanese patients with essential hypertension based on nocturnal blood pressure dipping status: A post hoc analysis of data from a randomized, double-blind multicenter study. J Am Heart Assoc 12: e027612, 202310.1161/JAHA.122.027612PubMed)| false
ZhangJ, ZhangW, YanJ, GeQ, LuX-H, ChenS-X, et al.: Efficacy and safety of sacubitril/allisartan for the treatment of primary hypertension: A phase 2 randomized, double-blind study. Hypertens Res46: 2024–2032, 202310.1038/s41440-023-01326-7PubMed
ZhangJ, ZhangW, YanJ, GeQ, LuX-H, ChenS-X, : Efficacy and safety of sacubitril/allisartan for the treatment of primary hypertension: A phase 2 randomized, double-blind study. Hypertens Res 46: 2024–2032, 202310.1038/s41440-023-01326-7PubMed)| false
ZhangW, ZhangJ, YanJ, GeQ, LuX-H, ChenS-X, et al.: Efficacy and safety of sacubitril/allisartan for the treatment of primary hypertension. JACC Asia4: 697–707, 202410.1016/j.jacasi.2024.06.002PubMed
ZhangW, ZhangJ, YanJ, GeQ, LuX-H, ChenS-X, : Efficacy and safety of sacubitril/allisartan for the treatment of primary hypertension. JACC Asia 4: 697–707, 202410.1016/j.jacasi.2024.06.002PubMed)| false
HaynesR, JudgePK, StaplinN, HerringtonWG, StoreyBC, BethelA, et al.: Effects of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease. Circulation138: 1505–1514, 201810.1161/CIRCULATIONAHA.118.034818PubMed
AhwinP, MartinezD: The relationship between SGLT2 and systemic blood pressure regulation. Hypertens Res47: 2094–2103, 202410.1038/s41440-024-01723-6PubMed
AhwinP, MartinezD: The relationship between SGLT2 and systemic blood pressure regulation. Hypertens Res 47: 2094–2103, 202410.1038/s41440-024-01723-6PubMed)| false
ZhangR, XieQ, LuX, FanR, TongN: Research advances in the anti-inflammatory effects of SGLT inhibitors in type 2 diabetes mellitus. Diabetol Metab Syndr16: 99, 202410.1186/s13098-024-01325-9PubMed
ZhangR, XieQ, LuX, FanR, TongN: Research advances in the anti-inflammatory effects of SGLT inhibitors in type 2 diabetes mellitus. Diabetol Metab Syndr 16: 99, 202410.1186/s13098-024-01325-9PubMed)| false
ZhangX-L, ZhuQ-Q, ChenY-H, LiX-L, ChenF, HuangJ-A, et al.: Cardiovascular safety, long-term noncardiovascular safety, and efficacy of sodium-glucose cotransporter 2 inhibitors in patients with type 2 diabetes mellitus: A systemic review and meta-analysis with trial sequential analysis. J Am Heart Assoc7: e007165, 201810.1161/JAHA.117.007165PubMed
ZhangX-L, ZhuQ-Q, ChenY-H, LiX-L, ChenF, HuangJ-A, : Cardiovascular safety, long-term noncardiovascular safety, and efficacy of sodium-glucose cotransporter 2 inhibitors in patients with type 2 diabetes mellitus: A systemic review and meta-analysis with trial sequential analysis. J Am Heart Assoc 7: e007165, 201810.1161/JAHA.117.007165PubMed)| false
PerkovicV, JardineMJ, NealB, BompointS, HeerspinkHJL, CharytanDM, et al.; CREDENCE Trial Investigators: Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. N Engl J Med380: 2295–2306, 201910.1056/NEJMoa1811744PubMed
PerkovicV, JardineMJ, NealB, BompointS, HeerspinkHJL, CharytanDM, ; CREDENCE Trial Investigators: Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. N Engl J Med 380: 2295–2306, 201910.1056/NEJMoa1811744PubMed)| false
ZhangQ, ZhouS, LiuL: Efficacy and safety evaluation of SGLT2i on blood pressure control in patients with type 2 diabetes and hypertension: A new meta-analysis. Diabetol Metab Syndr15: 118, 202310.1186/s13098-023-01092-zPubMed
ZhangQ, ZhouS, LiuL: Efficacy and safety evaluation of SGLT2i on blood pressure control in patients with type 2 diabetes and hypertension: A new meta-analysis. Diabetol Metab Syndr 15: 118, 202310.1186/s13098-023-01092-zPubMed)| false
LiuJJ, LeeT, DeFronzoRA: Why do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans?Diabetes61: 2199–2204, 201210.2337/db12-0052PubMed
LiuJJ, LeeT, DeFronzoRA: Why do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans?Diabetes 61: 2199–2204, 201210.2337/db12-0052PubMed)| false
WishJB, PergolaP: Evolution of mineralocorticoid receptor antagonists in the treatment of chronic kidney disease associated with type 2 diabetes mellitus. Mayo Clin Proc Innov Qual Outcomes6: 536–551, 202210.1016/j.mayocpiqo.2022.09.002PubMed
WishJB, PergolaP: Evolution of mineralocorticoid receptor antagonists in the treatment of chronic kidney disease associated with type 2 diabetes mellitus. Mayo Clin Proc Innov Qual Outcomes 6: 536–551, 202210.1016/j.mayocpiqo.2022.09.002PubMed)| false
BakrisG, PergolaPE, DelgadoB, GenovD, DoliashviliT, VoN, et al.; BLOCK-CKD Study Group: Effect of KBP-5074 on blood pressure in advanced chronic kidney disease: Results of the BLOCK-CKD study. Hypertension78: 74–81, 202110.1161/HYPERTENSIONAHA.121.17073PubMed
BakrisGL, AgarwalR, AnkerSD, PittB, RuilopeLM, RossingP, et al.; FIDELIO-DKD Investigators: Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes. N Engl J Med383: 2219–2229, 202010.1056/NEJMoa2025845PubMed
BakrisGL, AgarwalR, AnkerSD, PittB, RuilopeLM, RossingP, ; FIDELIO-DKD Investigators: Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes. N Engl J Med 383: 2219–2229, 202010.1056/NEJMoa2025845PubMed)| false
PittB, FilippatosG, AgarwalR, AnkerSD, BakrisGL, RossingP, et al.; FIGARO-DKD Investigators: Cardiovascular events with finerenone in kidney disease and type 2 diabetes. N Engl J Med385: 2252–2263, 202110.1056/NEJMoa2110956PubMed
PittB, FilippatosG, AgarwalR, AnkerSD, BakrisGL, RossingP, ; FIGARO-DKD Investigators: Cardiovascular events with finerenone in kidney disease and type 2 diabetes. N Engl J Med 385: 2252–2263, 202110.1056/NEJMoa2110956PubMed)| false
RuilopeLM, AgarwalR, AnkerSD, FilippatosG, PittB, RossingP, et al.; FIDELIO-DKD Investigators: Blood pressure and cardiorenal outcomes with finerenone in chronic kidney disease in type 2 diabetes. Hypertension79: 2685–2695, 202210.1161/HYPERTENSIONAHA.122.19744PubMed
AgarwalR, RuilopeLM, Ruiz-HurtadoG, HallerH, SchmiederRE, AnkerSD, et al.: Effect of finerenone on ambulatory blood pressure in chronic kidney disease in type 2 diabetes. J Hypertens41: 295–302, 202310.1097/HJH.0000000000003330PubMed
GadveSS, GadveSS, GadveS, ChavandaKS, HanamshettiS: 878-P: Effect of finerenone on resistant hypertension in type 2 diabetes mellitus—A randomized controlled trial in Indian population. Diabetes73: 878-P, 2024
GadveSS, GadveSS, GadveS, ChavandaKS, HanamshettiS: 878-P: Effect of finerenone on resistant hypertension in type 2 diabetes mellitus—A randomized controlled trial in Indian population. Diabetes 73: 878-P, 2024)| false
KarioK, OhbayashiH, HashimotoM, ItabashiN, KatoM, UchiyamaK, et al.; EXCITE-HT investigators: Home blood pressure-lowering effect of a non-steroidal mineralocorticoid receptor blocker, esaxerenone, versus trichlormethiazide for uncontrolled hypertension: The EXCITE-HT randomized controlled study. Hypertens Res47: 2435–2446, 202410.1038/s41440-024-01762-zPubMed
KarioK, OhbayashiH, HashimotoM, ItabashiN, KatoM, UchiyamaK, et al.; EXCITE-HT investigators: Home blood pressure-lowering effect of esaxerenone versus trichlormethiazide for uncontrolled hypertension: A predefined subanalysis of the EXCITE-HT randomized controlled trial by basal calcium channel blocker versus angiotensin receptor blocker. Hypertens Res48: 506–518, 202410.1038/s41440-024-01887-1PubMed
KarioK, OhbayashiH, HashimotoM, ItabashiN, KatoM, UchiyamaK, ; EXCITE-HT investigators: Home blood pressure-lowering effect of esaxerenone versus trichlormethiazide for uncontrolled hypertension: A predefined subanalysis of the EXCITE-HT randomized controlled trial by basal calcium channel blocker versus angiotensin receptor blocker. Hypertens Res 48: 506–518, 202410.1038/s41440-024-01887-1PubMed)| false
BakrisGL, SaxenaM, GuptaA, ChalhoubF, LeeJ, StiglitzD, et al.; KARDIA-1 Study Group: RNA interference with zilebesiran for mild to moderate hypertension: The KARDIA-1 randomized clinical trial. JAMA331: 740–749, 202410.1001/jama.2024.0728PubMed
BakrisGL: Zilebesiran in combination with a standard-of-care antihypertensive in patients with inadequately controlled hypertension - KARDIA-2. Presented at the 2024 Scientific Session of the American College of Cardiology, Atlanta, GA, April 6–8, 2024
BakrisGL: Zilebesiran in combination with a standard-of-care antihypertensive in patients with inadequately controlled hypertension - KARDIA-2. Presented at the 2024 Scientific Session of the American College of Cardiology, Atlanta, GA, April 6–8, 2024)| false
SaxenaM, AswadA, BadarieneJ, KarimA, SiaYT, StiglitzD, et al.: Subgroup results from KARDIA-2: Impact of demographic and baseline disease characteristics on zilebesiran response in patients with hypertension uncontrolled by a standard oral antihypertensive. Eur Heart J45: ehae666.2593, 2024https://doi.org/10.1093/eurheartj/ehae666.2593
SaxenaM, AswadA, BadarieneJ, KarimA, SiaYT, StiglitzD, : Subgroup results from KARDIA-2: Impact of demographic and baseline disease characteristics on zilebesiran response in patients with hypertension uncontrolled by a standard oral antihypertensive. Eur Heart J 45: ehae666.2593, 2024https://doi.org/10.1093/eurheartj/ehae666.2593)| false
HavasiA, PagidipatiN, BakrisG, WeberM, BengusM, DagaS, et al.: KARDIA-3 study design: Zilebesiran as add-on therapy in patients with high cardiovascular risk and hypertension inadequately controlled by standard of care antihypertensives. J Hypertens42: e120, 202410.1097/01.hjh.0001020524.16638.68
HavasiA, PagidipatiN, BakrisG, WeberM, BengusM, DagaS, : KARDIA-3 study design: Zilebesiran as add-on therapy in patients with high cardiovascular risk and hypertension inadequately controlled by standard of care antihypertensives. J Hypertens 42: e120, 202410.1097/01.hjh.0001020524.16638.68)| false
RayKK, TroquayRPT, VisserenFLJ, LeiterLA, Scott WrightR, VikarunnessaS, et al.: Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): Results from the 4-year open-label extension of the ORION-1 trial. Lancet Diabetes Endocrinol11: 109–119, 202310.1016/S2213-8587(22)00353-9PubMed
RayKK, TroquayRPT, VisserenFLJ, LeiterLA, Scott WrightR, VikarunnessaS, : Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): Results from the 4-year open-label extension of the ORION-1 trial. Lancet Diabetes Endocrinol 11: 109–119, 202310.1016/S2213-8587(22)00353-9PubMed)| false