TuttleKR, WongL, St PeterW, RobertsG, RangaswamiJ, MottlA, et al.; Diabetic Kidney Disease Collaborative Task Force: Moving from evidence to implementation of breakthrough therapies for diabetic kidney disease. Clin J Am Soc Nephrol17: 1092–1103, 202210.2215/CJN.02980322PubMed
de BoerIH, KhuntiK, SaduskyT, TuttleKR, NeumillerJJ, RheeCM, et al.: Diabetes management in chronic kidney disease: A consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int102: 974–989, 202210.1016/j.kint.2022.08.012PubMed
de BoerIH, KhuntiK, SaduskyT, TuttleKR, NeumillerJJ, RheeCM, : Diabetes management in chronic kidney disease: A consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 102: 974–989, 202210.1016/j.kint.2022.08.012PubMed)| false
KramerHJ, NguyenQD, CurhanG, HsuCY: Renal insufficiency in the absence of albuminuria and retinopathy among adults with type 2 diabetes mellitus. JAMA289: 3273–3277, 200310.1001/jama.289.24.3273PubMed
KramerHJ, NguyenQD, CurhanG, HsuCY: Renal insufficiency in the absence of albuminuria and retinopathy among adults with type 2 diabetes mellitus. JAMA 289: 3273–3277, 200310.1001/jama.289.24.3273PubMed)| false
OshimaM, ShimizuM, YamanouchiM, ToyamaT, HaraA, FuruichiK, et al.: Trajectories of kidney function in diabetes: A clinicopathological update. Nat Rev Nephrol17: 740–750, 202110.1038/s41581-021-00462-yPubMed
American Diabetes Association Professional Practice Committee: 11: Chronic kidney disease and risk management: Standards of Care in Diabetes—2025. Diabetes Care48: S239–S251, 202510.2337/dc25-S011PubMed
American Diabetes Association Professional Practice Committee: 11: Chronic kidney disease and risk management: Standards of Care in Diabetes—2025. Diabetes Care 48: S239–S251, 202510.2337/dc25-S011PubMed)| false
MillerWG, KaufmanHW, LeveyAS, StraseskiJA, WilhelmsKW, ElsieHY, et al.: National Kidney Foundation Laboratory Engagement Working Group recommendations for implementing the CKD-EPI 2021 race-free equations for estimated glomerular filtration rate: Practical guidance for clinical laboratories. Clin Chem68: 511–520, 202210.1093/clinchem/hvab278PubMed
MillerWG, KaufmanHW, LeveyAS, StraseskiJA, WilhelmsKW, ElsieHY, : National Kidney Foundation Laboratory Engagement Working Group recommendations for implementing the CKD-EPI 2021 race-free equations for estimated glomerular filtration rate: Practical guidance for clinical laboratories. Clin Chem 68: 511–520, 202210.1093/clinchem/hvab278PubMed)| false
InkerLA, EneanyaND, CoreshJ, TighiouartH, WangD, SangY, et al.; Chronic Kidney Disease Epidemiology Collaboration: New creatinine- and cystatin C-based equations to estimate GFR without race. N Engl J Med385: 1737–1749, 202110.1056/NEJMoa2102953PubMed
InkerLA, EneanyaND, CoreshJ, TighiouartH, WangD, SangY, ; Chronic Kidney Disease Epidemiology Collaboration: New creatinine- and cystatin C-based equations to estimate GFR without race. N Engl J Med 385: 1737–1749, 202110.1056/NEJMoa2102953PubMed)| false
MendeCW, BloomgardenZ: Measurement of renal function: Should cystatin C be more widely used for people with diabetes?J Diabetes16: e13534, 202410.1111/1753-0407.13534PubMed
MendeCW, BloomgardenZ: Measurement of renal function: Should cystatin C be more widely used for people with diabetes?J Diabetes 16: e13534, 202410.1111/1753-0407.13534PubMed)| false
Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group: KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int105: S117–S314, 202410.1016/j.kint.2023.10.018PubMed
Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group: KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int 105: S117–S314, 202410.1016/j.kint.2023.10.018PubMed)| false
StempniewiczN, VassalottiJA, CuddebackJK, CieminsE, Storfer-IsserA, SangY, et al.: Chronic kidney disease testing among primary care patients with type 2 diabetes across 24 U.S. health care organizations. Diabetes Care44: 2000–2009, 202110.2337/dc20-2715PubMed
StempniewiczN, VassalottiJA, CuddebackJK, CieminsE, Storfer-IsserA, SangY, : Chronic kidney disease testing among primary care patients with type 2 diabetes across 24 U.S. health care organizations. Diabetes Care 44: 2000–2009, 202110.2337/dc20-2715PubMed)| false
EdmonstonD, LydonE, MulderH, ChiswellK, LampronZ, MarsoloK, et al.: Concordance with screening and treatment guidelines for chronic kidney disease in type 2 diabetes. JAMA Netw Open7: e2418808, 202410.1001/jamanetworkopen.2024.18808PubMed
EdmonstonD, LydonE, MulderH, ChiswellK, LampronZ, MarsoloK, : Concordance with screening and treatment guidelines for chronic kidney disease in type 2 diabetes. JAMA Netw Open 7: e2418808, 202410.1001/jamanetworkopen.2024.18808PubMed)| false
Sperl-HillenJ, CrainAL, WetmoreJB, ChumbaLN, O’ConnorPJ: A CKD clinical decision support system: A cluster randomized clinical trial in primary care clinics. Kidney Med6: 100777, 202410.1016/j.xkme.2023.100777PubMed
Sperl-HillenJ, CrainAL, WetmoreJB, ChumbaLN, O’ConnorPJ: A CKD clinical decision support system: A cluster randomized clinical trial in primary care clinics. Kidney Med 6: 100777, 202410.1016/j.xkme.2023.100777PubMed)| false
KotsisF, BächleH, AltenbuchingerM, DönitzJ, Njipouombe NsangouYA, MeiselbachH, et al.: Expectation of clinical decision support systems: A survey study among nephrologist end-users. BMC Med Inform Decis Mak23: 239, 202310.1186/s12911-023-02317-xPubMed
KotsisF, BächleH, AltenbuchingerM, DönitzJ, Njipouombe NsangouYA, MeiselbachH, : Expectation of clinical decision support systems: A survey study among nephrologist end-users. BMC Med Inform Decis Mak 23: 239, 202310.1186/s12911-023-02317-xPubMed)| false
SunY, RenY, LanP, YuX, FengJ, HaoD, et al.: Clinico-pathological features of diabetic and non-diabetic renal diseases in type 2 diabetic patients: A retrospective study from a 10-year experience in a single center. Int Urol Nephrol55: 2303–2312, 202310.1007/s11255-023-03478-4PubMed
SunY, RenY, LanP, YuX, FengJ, HaoD, : Clinico-pathological features of diabetic and non-diabetic renal diseases in type 2 diabetic patients: A retrospective study from a 10-year experience in a single center. Int Urol Nephrol 55: 2303–2312, 202310.1007/s11255-023-03478-4PubMed)| false
BasuM, PulaiS, NeogiS, BanerjeeM, BhattacharyyaNP, SenguptaS, et al.: Prevalence of non-diabetic kidney disease and inability of clinical predictors to differentiate it from diabetic kidney disease: Results from a prospectively performed renal biopsy study. BMJ Open Diabetes Res Care10: e003058, 202210.1136/bmjdrc-2022-003058PubMed
BasuM, PulaiS, NeogiS, BanerjeeM, BhattacharyyaNP, SenguptaS, : Prevalence of non-diabetic kidney disease and inability of clinical predictors to differentiate it from diabetic kidney disease: Results from a prospectively performed renal biopsy study. BMJ Open Diabetes Res Care 10: e003058, 202210.1136/bmjdrc-2022-003058PubMed)| false
DongZ, WangY, QiuQ, ZhangX, ZhangL, WuJ, et al.: Clinical predictors differentiating non-diabetic renal diseases from diabetic nephropathy in a large population of type 2 diabetes patients. Diabetes Res Clin Pract121: 112–118, 201610.1016/j.diabres.2016.09.005PubMed
DongZ, WangY, QiuQ, ZhangX, ZhangL, WuJ, : Clinical predictors differentiating non-diabetic renal diseases from diabetic nephropathy in a large population of type 2 diabetes patients. Diabetes Res Clin Pract 121: 112–118, 201610.1016/j.diabres.2016.09.005PubMed)| false
ZhangW, LiuX, DongZ, WangQ, PeiZ, ChenY, et al.: New diagnostic model for the differentiation of diabetic nephropathy from non-diabetic nephropathy in Chinese patients. Front Endocrinol (Lausanne)13: 913021, 202210.3389/fendo.2022.913021PubMed
ZhangW, LiuX, DongZ, WangQ, PeiZ, ChenY, : New diagnostic model for the differentiation of diabetic nephropathy from non-diabetic nephropathy in Chinese patients. Front Endocrinol (Lausanne) 13: 913021, 202210.3389/fendo.2022.913021PubMed)| false
ChuL, FullerM, JervisK, CiacciaA, AbitbolA: Prevalence of chronic kidney disease in type 2 diabetes: The Canadian Registry of Chronic Kidney Disease in Diabetes Outcomes (CREDO) study. Clin Ther43: 1558–1573, 202110.1016/j.clinthera.2021.07.015PubMed
ChuL, FullerM, JervisK, CiacciaA, AbitbolA: Prevalence of chronic kidney disease in type 2 diabetes: The Canadian Registry of Chronic Kidney Disease in Diabetes Outcomes (CREDO) study. Clin Ther 43: 1558–1573, 202110.1016/j.clinthera.2021.07.015PubMed)| false
MoralesJ, HandelsmanY: Cardiovascular outcomes in patients with diabetes and kidney disease: JACC review topic of the week. J Am Coll Cardiol82: 161–170, 202310.1016/j.jacc.2023.04.052PubMed
MoralesJ, HandelsmanY: Cardiovascular outcomes in patients with diabetes and kidney disease: JACC review topic of the week. J Am Coll Cardiol 82: 161–170, 202310.1016/j.jacc.2023.04.052PubMed)| false
KishorS, ChenJ, ZhangY, LiuW, ZhuL, XuJ, et al.: Interaction of proteinuria and diabetes on the risk of cardiovascular events: A prospective cohort CKD-ROUTE study. BMC Public Health24: 3192, 202410.1186/s12889-024-20715-2PubMed
KishorS, ChenJ, ZhangY, LiuW, ZhuL, XuJ, : Interaction of proteinuria and diabetes on the risk of cardiovascular events: A prospective cohort CKD-ROUTE study. BMC Public Health 24: 3192, 202410.1186/s12889-024-20715-2PubMed)| false
GersteinHC, MianR, RamasundarahettigeC, BranchKRH, Del PratoS, LamCSP, et al.: Cardiovascular and renal outcomes with varying degrees of kidney disease in high-risk people with type 2 diabetes: An epidemiological analysis of data from the AMPLITUDE-O trial. Diabetes Obes Metab26: 1216–1223, 202410.1111/dom.15417PubMed
GersteinHC, MianR, RamasundarahettigeC, BranchKRH, Del PratoS, LamCSP, : Cardiovascular and renal outcomes with varying degrees of kidney disease in high-risk people with type 2 diabetes: An epidemiological analysis of data from the AMPLITUDE-O trial. Diabetes Obes Metab 26: 1216–1223, 202410.1111/dom.15417PubMed)| false
MarxN, FedericiM, SchüttK, Müller-WielandD, AjjanRA, AntunesMJ, et al.; ESC Scientific Document Group: 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes. Eur Heart J44: 4043–4140, 202310.1093/eurheartj/ehad192PubMed
NdumeleCE, NeelandIJ, TuttleKR, ChowSL, MathewRO, KhanSS, et al.; American Heart Association: A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: A scientific statement from the American Heart Association. Circulation148: 1636–1664, 202310.1161/CIR.0000000000001186PubMed
NdumeleCE, NeelandIJ, TuttleKR, ChowSL, MathewRO, KhanSS, ; American Heart Association: A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: A scientific statement from the American Heart Association. Circulation 148: 1636–1664, 202310.1161/CIR.0000000000001186PubMed)| false
KhanSS, CoreshJ, PencinaMJ, NdumeleCE, RangaswamiJ, ChowSL, et al.; American Heart Association: Novel prediction equations for absolute risk assessment of total cardiovascular disease incorporating cardiovascular-kidney-metabolic health: A scientific statement from the American Heart Association. Circulation148: 1982–2004, 202310.1161/CIR.0000000000001191PubMed
KhanSS, CoreshJ, PencinaMJ, NdumeleCE, RangaswamiJ, ChowSL, ; American Heart Association: Novel prediction equations for absolute risk assessment of total cardiovascular disease incorporating cardiovascular-kidney-metabolic health: A scientific statement from the American Heart Association. Circulation 148: 1982–2004, 202310.1161/CIR.0000000000001191PubMed)| false
ChenZ, MalekV, NatarajanR: Update: The role of epigenetics in the metabolic memory of diabetic complications. Am J Physiol Renal Physiol327: F327–F339, 202410.1152/ajprenal.00115.2024PubMed
ChenZ, MalekV, NatarajanR: Update: The role of epigenetics in the metabolic memory of diabetic complications. Am J Physiol Renal Physiol 327: F327–F339, 202410.1152/ajprenal.00115.2024PubMed)| false
TianJ, ChenJ, SunQ, HuangT, XuH, WangJ, et al.: Effects of the S1P/S1PR1 signaling pathway on high glucose-induced NRK-52E epithelial-mesenchymal transition via regulation of ROS/NLRP3 [published online ahead of print Aug 7, 2024]. Inflammation, doi:10.1007/s10753-024-02118-yPubMed
TianJ, ChenJ, SunQ, HuangT, XuH, WangJ, : Effects of the S1P/S1PR1 signaling pathway on high glucose-induced NRK-52E epithelial-mesenchymal transition via regulation of ROS/NLRP3 [published online ahead of print Aug 7, 2024]. Inflammation, doi:10.1007/s10753-024-02118-yPubMed)| false
ShengY, ZhangC, HuangJ, WangD, XiaoQ, ZhangH, et al.: Comparison of conventional mathematical model and machine learning model based on recent advances in mathematical models for predicting diabetic kidney disease. Digit Health10: 20552076241238093, 202410.1177/20552076241238093PubMed
ShengY, ZhangC, HuangJ, WangD, XiaoQ, ZhangH, : Comparison of conventional mathematical model and machine learning model based on recent advances in mathematical models for predicting diabetic kidney disease. Digit Health 10: 20552076241238093, 202410.1177/20552076241238093PubMed)| false
DholariyaS, DuttaS, SonagraA, KaliyaM, SinghR, ParchwaniD, et al.: Unveiling the utility of artificial intelligence for prediction, diagnosis, and progression of diabetic kidney disease: An evidence-based systematic review and meta-analysis. Curr Med Res Opin13: 1–31, 202410.1080/03007995.2024.2423737PubMed
DholariyaS, DuttaS, SonagraA, KaliyaM, SinghR, ParchwaniD, : Unveiling the utility of artificial intelligence for prediction, diagnosis, and progression of diabetic kidney disease: An evidence-based systematic review and meta-analysis. Curr Med Res Opin 13: 1–31, 202410.1080/03007995.2024.2423737PubMed)| false
HanYZ, ZhengHJ, DuBX, ZhangY, ZhuXY, LiJ, et al.: Role of gut microbiota, immune imbalance, and allostatic load in the occurrence and development of diabetic kidney disease. J Diabetes Res2023: 8871677, 202310.1155/2023/8871677PubMed
HanYZ, ZhengHJ, DuBX, ZhangY, ZhuXY, LiJ, : Role of gut microbiota, immune imbalance, and allostatic load in the occurrence and development of diabetic kidney disease. J Diabetes Res 2023: 8871677, 202310.1155/2023/8871677PubMed)| false
ZhouP, HaoZ, ChenY, ZhangZ, XuW, YuJ: Association between gut microbiota and diabetic microvascular complications: A two-sample Mendelian randomization study. Front Endocrinol (Lausanne)15: 1364280, 202410.3389/fendo.2024.1364280PubMed
ZhouP, HaoZ, ChenY, ZhangZ, XuW, YuJ: Association between gut microbiota and diabetic microvascular complications: A two-sample Mendelian randomization study. Front Endocrinol (Lausanne) 15: 1364280, 202410.3389/fendo.2024.1364280PubMed)| false
ZhangX, ChaoP, ZhangL, XuL, CuiX, WangS, et al.: Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease. Front Immunol14: 1030198, 202310.3389/fimmu.2023.1030198PubMed
ZhangX, ChaoP, ZhangL, XuL, CuiX, WangS, : Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease. Front Immunol 14: 1030198, 202310.3389/fimmu.2023.1030198PubMed)| false
LuoY, LiuL, ZhangC: Identification and analysis of diverse cell death patterns in diabetic kidney disease using microarray-based transcriptome profiling and single-nucleus RNA sequencing. Comput Biol Med169: 107780, 202410.1016/j.compbiomed.2023.107780PubMed
LuoY, LiuL, ZhangC: Identification and analysis of diverse cell death patterns in diabetic kidney disease using microarray-based transcriptome profiling and single-nucleus RNA sequencing. Comput Biol Med 169: 107780, 202410.1016/j.compbiomed.2023.107780PubMed)| false
PoulsenCG, JesseK, CarstensenB, Frimodt-MøllerM, HansenTW, PerssonF, VistisenD, et al.: Prognosis for type 1 diabetes with diabetic nephropathy between 2000 and 2020 - Changes in kidney function decline over time and development of cardiovascular disease, kidney failure, and mortality. Kidney Int Rep9: 3403–3413, 202410.1016/j.ekir.2024.09.010PubMed
PoulsenCG, JesseK, CarstensenB, Frimodt-MøllerM, HansenTW, PerssonF, VistisenD, : Prognosis for type 1 diabetes with diabetic nephropathy between 2000 and 2020 - Changes in kidney function decline over time and development of cardiovascular disease, kidney failure, and mortality. Kidney Int Rep 9: 3403–3413, 202410.1016/j.ekir.2024.09.010PubMed)| false
European Medicines Agency: Public statement: Forxiga 5mg should no longer be used for the treatment of type 1 diabetes mellitus, 2021. Available at: https://www.ema.europa.eu/en/medicines/dhpc/forxiga. Accessed November 23, 2023
European Medicines Agency: Public statement: Forxiga 5mg should no longer be used for the treatment of type 1 diabetes mellitus, 2021. Available at: https://www.ema.europa.eu/en/medicines/dhpc/forxiga. Accessed November 23, 2023)| false
European Medicines Agency: Public statement: Zynquista—Withdrawal of the marketing authorisation in the European Union,2022. Available at: https://www.ema.europa.eu/en/documents/public-statement/public-statement-zynquista-withdrawal-marketing-authorisation-european-union_en.pdf. Accessed November 23, 2023)| false
BakrisGL, AgarwalR, AnkerSD, PittB, RuilopeLM, RossingP, et al.; FIDELIO-DKD Investigators: Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes. N Engl J Med383: 2219–2229, 202010.1056/NEJMoa2025845PubMed
BakrisGL, AgarwalR, AnkerSD, PittB, RuilopeLM, RossingP, ; FIDELIO-DKD Investigators: Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes. N Engl J Med 383: 2219–2229, 202010.1056/NEJMoa2025845PubMed)| false
PittB, FilippatosG, AgarwalR, AnkerSD, BakrisGL, RossingP, et al.; FIGARO-DKD Investigators: Cardiovascular events with finerenone in kidney disease and type 2 diabetes. N Engl J Med385: 2252–2263, 202110.1056/NEJMoa2110956PubMed
PittB, FilippatosG, AgarwalR, AnkerSD, BakrisGL, RossingP, ; FIGARO-DKD Investigators: Cardiovascular events with finerenone in kidney disease and type 2 diabetes. N Engl J Med 385: 2252–2263, 202110.1056/NEJMoa2110956PubMed)| false
HeerspinkHJL, BirkenfeldAL, CherneyDZI, ColhounHM, JiL, MathieuC, et al.: Rationale and design of a randomised phase III registration trial investigating finerenone in participants with type 1 diabetes and chronic kidney disease: The FINE-ONE trial. Diabetes Res Clin Pract204: 110908, 202310.1016/j.diabres.2023.110908PubMed
HeerspinkHJL, BirkenfeldAL, CherneyDZI, ColhounHM, JiL, MathieuC, : Rationale and design of a randomised phase III registration trial investigating finerenone in participants with type 1 diabetes and chronic kidney disease: The FINE-ONE trial. Diabetes Res Clin Pract 204: 110908, 202310.1016/j.diabres.2023.110908PubMed)| false
SloanL: SGLT2 inhibitors across the spectrum of chronic kidney disease: A narrative review. Postgrad Med136: 801–809, 202410.1080/00325481.2024.2418795PubMed
SloanL: SGLT2 inhibitors across the spectrum of chronic kidney disease: A narrative review. Postgrad Med 136: 801–809, 202410.1080/00325481.2024.2418795PubMed)| false
LieverseTTGF, PuchadesMJ, MulderUDJ, ProvenzanoM, KrenningG, JongsN, et al.: Glomerular and tubular effects of dapagliflozin, eplerenone and their combination in patients with chronic kidney disease: A post-hoc analysis of the ROTATE-3 study. Diabetes Obes Metab26: 576–582, 202410.1111/dom.15346PubMed
LieverseTTGF, PuchadesMJ, MulderUDJ, ProvenzanoM, KrenningG, JongsN, : Glomerular and tubular effects of dapagliflozin, eplerenone and their combination in patients with chronic kidney disease: A post-hoc analysis of the ROTATE-3 study. Diabetes Obes Metab 26: 576–582, 202410.1111/dom.15346PubMed)| false
BakrisGL, RuilopeLM, AnkerSD, FilippatosG, PittB, RossingP, et al.; FIDELIO-DKD and FIGARO-DKD Investigators: A prespecified exploratory analysis from FIDELITY examined finerenone use and kidney outcomes in patients with chronic kidney disease and type 2 diabetes. Kidney Int103: 196–206, 202310.1016/j.kint.2022.08.040PubMed
BakrisGL, RuilopeLM, AnkerSD, FilippatosG, PittB, RossingP, ; FIDELIO-DKD and FIGARO-DKD Investigators: A prespecified exploratory analysis from FIDELITY examined finerenone use and kidney outcomes in patients with chronic kidney disease and type 2 diabetes. Kidney Int 103: 196–206, 202310.1016/j.kint.2022.08.040PubMed)| false
AgarwalR, TuW, FarjatAE, FaragYMK, TotoR, KaulS, et al.; FIDELIO-DKD and FIGARO-DKD Investigators: Impact of finerenone-induced albuminuria reduction on chronic kidney disease outcomes in type 2 diabetes: A mediation analysis. Ann Intern Med176: 1606–1616, 202310.7326/M23-1023PubMed
AgarwalR, TuW, FarjatAE, FaragYMK, TotoR, KaulS, ; FIDELIO-DKD and FIGARO-DKD Investigators: Impact of finerenone-induced albuminuria reduction on chronic kidney disease outcomes in type 2 diabetes: A mediation analysis. Ann Intern Med 176: 1606–1616, 202310.7326/M23-1023PubMed)| false
NicholasSB, Correa-RotterR, DesaiNR, GuoL, NavaneethanSD, PantaloneKM, et al.: First interim results from FINE-REAL: A prospective, non-interventional, phase 4 study providing insights into the use and safety of finerenone in a routine clinical setting. J Nephrol37: 2223–2232, 202410.1007/s40620-024-02070-yPubMed
NicholasSB, Correa-RotterR, DesaiNR, GuoL, NavaneethanSD, PantaloneKM, : First interim results from FINE-REAL: A prospective, non-interventional, phase 4 study providing insights into the use and safety of finerenone in a routine clinical setting. J Nephrol 37: 2223–2232, 202410.1007/s40620-024-02070-yPubMed)| false
RiveraFB, CruzLLA, MagalongJV, RuyerasJMMJ, ApareceJP, BantayanNRB, et al.: Cardiovascular and renal outcomes of glucagon-like peptide 1 receptor agonists among patients with and without type 2 diabetes mellitus: A meta-analysis of randomized placebo-controlled trials. Am J Prev Cardiol18: 100679100679, 202410.1016/j.ajpc.2024.100679PubMed
RiveraFB, CruzLLA, MagalongJV, RuyerasJMMJ, ApareceJP, BantayanNRB, : Cardiovascular and renal outcomes of glucagon-like peptide 1 receptor agonists among patients with and without type 2 diabetes mellitus: A meta-analysis of randomized placebo-controlled trials. Am J Prev Cardiol 18: 100679100679, 202410.1016/j.ajpc.2024.100679PubMed)| false
MannJFE, ØrstedDD, Brown-FrandsenK, MarsoSP, PoulterNR, RasmussenS, et al.; LEADER Steering Committee and Investigators: Liraglutide and renal outcomes in type 2 diabetes. N Engl J Med377: 839–848, 201710.1056/NEJMoa1616011PubMed
MannJFE, ØrstedDD, Brown-FrandsenK, MarsoSP, PoulterNR, RasmussenS, ; LEADER Steering Committee and Investigators: Liraglutide and renal outcomes in type 2 diabetes. N Engl J Med 377: 839–848, 201710.1056/NEJMoa1616011PubMed)| false
GersteinHC, ColhounHM, DagenaisGR, DiazR, LakshmananM, PaisP, et al.; REWIND Investigators: Dulaglutide and renal outcomes in type 2 diabetes: An exploratory analysis of the REWIND randomised, placebo-controlled trial. Lancet394: 131–138, 201910.1016/S0140-6736(19)31150-XPubMed
MarsoSP, BainSC, ConsoliA, EliaschewitzFG, JódarE, LeiterLA, SUSTAIN-6 Investigators, et al.: Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med375: 1834–1844, 201610.1056/NEJMoa1607141PubMed
MarsoSP, BainSC, ConsoliA, EliaschewitzFG, JódarE, LeiterLA, SUSTAIN-6 Investigators, : Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med 375: 1834–1844, 201610.1056/NEJMoa1607141PubMed)| false
PerkovicV, TuttleKR, RossingP, MahaffeyKW, MannJFE, BakrisG, FLOW Trial Committees and Investigators, et al.: Effects of semaglutide on chronic kidney disease in patients with type 2 diabetes. N Engl J Med391: 109–121, 202410.1056/NEJMoa2403347PubMed
PerkovicV, TuttleKR, RossingP, MahaffeyKW, MannJFE, BakrisG, FLOW Trial Committees and Investigators, : Effects of semaglutide on chronic kidney disease in patients with type 2 diabetes. N Engl J Med 391: 109–121, 202410.1056/NEJMoa2403347PubMed)| false
ElSayedNA, McCoyRG, AleppoG, BajajM, BalapattabiK, BeverlyEA, et al.; American Diabetes Association Professional Practice Committee: Pharmacologic approaches to glycemic treatment: Standards of Care in Diabetes. Diabetes Care48: S181–S206, 202510.2337/dc25-S009PubMed
ElSayedNA, McCoyRG, AleppoG, BajajM, BalapattabiK, BeverlyEA, ; American Diabetes Association Professional Practice Committee: Pharmacologic approaches to glycemic treatment: Standards of Care in Diabetes. Diabetes Care 48: S181–S206, 202510.2337/dc25-S009PubMed)| false
ApperlooEM, NeuenBL, FletcherRA, JongsN, AnkerSD, BhattDL, et al.: Efficacy and safety of SGLT2 inhibitors with and without glucagon-like peptide 1 receptor agonists: A SMART-C collaborative meta-analysis of randomised controlled trials. Lancet Diabetes Endocrinol12: 545–557, 202410.1016/S2213-8587(24)00155-4PubMed
HaddockB, KristensenKB, TayyabM, LarssonHBW, LindbergU, VestergaardM, et al.: GLP-1 promotes cortical and medullary perfusion in the human kidney and maintains renal oxygenation during NaCl loading. J Am Heart Assoc12: e027712, 202310.1161/JAHA.122.027712PubMed
HaddockB, KristensenKB, TayyabM, LarssonHBW, LindbergU, VestergaardM, : GLP-1 promotes cortical and medullary perfusion in the human kidney and maintains renal oxygenation during NaCl loading. J Am Heart Assoc 12: e027712, 202310.1161/JAHA.122.027712PubMed)| false
ApperlooEM, GorrizJL, SolerMJ, Cigarrán GuldrisS, CruzadoJM, PuchadesMJ, et al.: Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: A randomized double-blind placebo-controlled clinical trial. Nat Med31: 278–285, 202410.1038/s41591-024-03327-6PubMed
ApperlooEM, GorrizJL, SolerMJ, Cigarrán GuldrisS, CruzadoJM, PuchadesMJ, : Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: A randomized double-blind placebo-controlled clinical trial. Nat Med 31: 278–285, 202410.1038/s41591-024-03327-6PubMed)| false
ColhounHM, LingvayI, BrownPM, DeanfieldJ, Brown-FrandsenK, KahnSE, et al.: Long-term kidney outcomes of semaglutide in obesity and cardiovascular disease in the SELECT trial. Nat Med30: 2058–2066, 202410.1038/s41591-024-03015-5PubMed
ColhounHM, LingvayI, BrownPM, DeanfieldJ, Brown-FrandsenK, KahnSE, : Long-term kidney outcomes of semaglutide in obesity and cardiovascular disease in the SELECT trial. Nat Med 30: 2058–2066, 202410.1038/s41591-024-03015-5PubMed)| false
BadveSV, BilalA, LeeMMY, SattarN, GersteinHC, RuffCT, et al.: Effects of GLP-1 receptor agonists on kidney and cardiovascular disease outcomes: A meta-analysis of randomised controlled trials. Lancet Diabetes Endocrinol13: 15–28, 202510.1016/S2213-8587(24)00271-7PubMed
YangC-T, YaoW-Y, OuH-T, KuoS: Value of GLP-1 receptor agonists versus long-acting insulins for type 2 diabetes patients with and without established cardiovascular or chronic kidney diseases: A model-based cost-effectiveness analysis using real-world data. Diabetes Res Clin Pract198: 110625, 202310.1016/j.diabres.2023.110625PubMed
YangC-T, YaoW-Y, OuH-T, KuoS: Value of GLP-1 receptor agonists versus long-acting insulins for type 2 diabetes patients with and without established cardiovascular or chronic kidney diseases: A model-based cost-effectiveness analysis using real-world data. Diabetes Res Clin Pract 198: 110625, 202310.1016/j.diabres.2023.110625PubMed)| false
HeerspinkHJL, ParvingH-H, AndressDL, BakrisG, Correa-RotterR, HouF-F, et al.; SONAR Committees and Investigators: Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): A double-blind, randomised, placebo-controlled trial. Lancet393: 1937–1947, 201910.1016/S0140-6736(19)30772-XPubMed
HeerspinkHJL, KiyosueA, WheelerDC, LinM, WijkmarkE, CarlsonG, et al.: Zibotentan in combination with dapagliflozin compared with dapagliflozin in patients with chronic kidney disease (ZENITH-CKD): A multicentre, randomised, active-controlled, phase 2b, clinical trial. Lancet402: 2004–2017, 202310.1016/S0140-6736(23)02230-4PubMed
SmeijerJD, WasehuusVS, DhaunN, GórrizJL, SolerMJ, ÅstrandM, et al.: Effects of zibotentan alone and in combination with dapagliflozin on fluid retention in patients with CKD. J Am Soc Nephrol35: 1381–1390, 202410.1681/ASN.0000000000000436PubMed
SmeijerJD, WasehuusVS, DhaunN, GórrizJL, SolerMJ, ÅstrandM, : Effects of zibotentan alone and in combination with dapagliflozin on fluid retention in patients with CKD. J Am Soc Nephrol 35: 1381–1390, 202410.1681/ASN.0000000000000436PubMed)| false
KrishnanSM, KraehlingJR, EitnerF, BenardeauA, SandnerP: The impact of the nitric oxide (NO)/soluble guanylyl cyclase (sGC) signaling cascade on kidney health and disease: A preclinical perspective. Int J Mol Sci19: 1712, 201810.3390/ijms19061712PubMed
KrishnanSM, KraehlingJR, EitnerF, BenardeauA, SandnerP: The impact of the nitric oxide (NO)/soluble guanylyl cyclase (sGC) signaling cascade on kidney health and disease: A preclinical perspective. Int J Mol Sci 19: 1712, 201810.3390/ijms19061712PubMed)| false
HeerspinkHJL, CherneyD, GaforAHA, GórrizJL, PergolaPE, TangSCW, et al.: Effect of avenciguat on albuminuria in patients with CKD: Two randomized placebo-controlled trials. J Am Soc Nephrol35: 1227–1239, 202410.1681/ASN.0000000000000418PubMed
HeerspinkHJL, CherneyD, GaforAHA, GórrizJL, PergolaPE, TangSCW, : Effect of avenciguat on albuminuria in patients with CKD: Two randomized placebo-controlled trials. J Am Soc Nephrol 35: 1227–1239, 202410.1681/ASN.0000000000000418PubMed)| false
BornsteinSR, de ZeeuwD, HeerspinkHJL, SchulzeF, CroninL, WenzA, et al.: Aldosterone synthase inhibitor (BI 690517) therapy for people with diabetes and albuminuric chronic kidney disease: A multicentre, randomized, double-blind, placebo-controlled, Phase I trial. Diabetes Obes Metab26: 2128–2138, 202410.1111/dom.15518PubMed
BornsteinSR, de ZeeuwD, HeerspinkHJL, SchulzeF, CroninL, WenzA, : Aldosterone synthase inhibitor (BI 690517) therapy for people with diabetes and albuminuric chronic kidney disease: A multicentre, randomized, double-blind, placebo-controlled, Phase I trial. Diabetes Obes Metab 26: 2128–2138, 202410.1111/dom.15518PubMed)| false
TuttleKR, HauskeSJ, CanzianiME, CaramoriML, CherneyD, CroninL, et al.; ASi in CKD group: Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: A randomised, controlled, phase 2 trial. Lancet403: 379–390, 202410.1016/S0140-6736(23)02408-XPubMed
TuttleKR, HauskeSJ, CanzianiME, CaramoriML, CherneyD, CroninL, ; ASi in CKD group: Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: A randomised, controlled, phase 2 trial. Lancet 403: 379–390, 202410.1016/S0140-6736(23)02408-XPubMed)| false
JudgePK, TuttleKR, StaplinN, HauskeSJ, ZhuD, SardellR, et al.: The potential for improving cardio-renal outcomes in chronic kidney disease with the aldosterone synthase inhibitor vicadrostat (BI 690517): A rationale for the EASi-KIDNEY trial. Nephrol Dial Transplant12: gfae263, 202410.1093/ndt/gfae263PubMed
JudgePK, TuttleKR, StaplinN, HauskeSJ, ZhuD, SardellR, : The potential for improving cardio-renal outcomes in chronic kidney disease with the aldosterone synthase inhibitor vicadrostat (BI 690517): A rationale for the EASi-KIDNEY trial. Nephrol Dial Transplant 12: gfae263, 202410.1093/ndt/gfae263PubMed)| false
NeuenBL, HeerspinkHJL, VartP, ClaggettBL, FletcherRA, ArnottC, et al.: Estimated lifetime cardiovascular, kidney, and mortality benefits of combination treatment with SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal MRA compared with conventional care in patients with type 2 diabetes and albuminuria. Circulation149: 450–462, 202410.1161/CIRCULATIONAHA.123.067584PubMed
NeuenBL, HeerspinkHJL, VartP, ClaggettBL, FletcherRA, ArnottC, : Estimated lifetime cardiovascular, kidney, and mortality benefits of combination treatment with SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal MRA compared with conventional care in patients with type 2 diabetes and albuminuria. Circulation 149: 450–462, 202410.1161/CIRCULATIONAHA.123.067584PubMed)| false
HandelsmanY, AndersonJE, BakrisGL, BallantyneCM, BeckmanJA, BhattDL, et al.: DCRM multispecialty practice recommendations for the management of diabetes, cardiorenal, and metabolic diseases. J Diabetes Complications36: 108101, 202210.1016/j.jdiacomp.2021.108101PubMed
HandelsmanY, AndersonJE, BakrisGL, BallantyneCM, BhattDL, BloomgardenZT, et al.: DCRM 2.0: Multispecialty practice recommendations for the management of diabetes, cardiorenal, and metabolic diseases. Metabolism159: 155931, 202410.1016/j.metabol.2024.155931PubMed
RikinS, BaumanL, ArnaoudovaI, DiPaloK, SudaN, GuptaS, et al.: Multidisciplinary proactive e-consults to improve guideline-directed medical therapies for patients with diabetes and chronic kidney disease: an implementation study. BMJ Open Diabetes Res Care12: e004155, 202410.1136/bmjdrc-2024-004155PubMed
RikinS, BaumanL, ArnaoudovaI, DiPaloK, SudaN, GuptaS, : Multidisciplinary proactive e-consults to improve guideline-directed medical therapies for patients with diabetes and chronic kidney disease: an implementation study. BMJ Open Diabetes Res Care 12: e004155, 202410.1136/bmjdrc-2024-004155PubMed)| false
ElSayedNA, McCoyRG, AleppoG, BajajM, BalapattabiK, BeverlyEA, et al.; American Diabetes Association Professional Practice Committee: Comprehensive medical evaluation and assessment of comorbidities: Standards of Care in Diabetes—2024. Diabetes Care48: S59–S85, 202510.2337/dc25-S004PubMed
ElSayedNA, McCoyRG, AleppoG, BajajM, BalapattabiK, BeverlyEA, ; American Diabetes Association Professional Practice Committee: Comprehensive medical evaluation and assessment of comorbidities: Standards of Care in Diabetes—2024. Diabetes Care 48: S59–S85, 202510.2337/dc25-S004PubMed)| false
KelepourisE, St PeterW, NeumillerJJ, WrightEE: Optimizing multidisciplinary care of patients with chronic kidney disease and type 2 diabetes mellitus. Diabetes Ther14: 1111–1136, 202310.1007/s13300-023-01416-2PubMed
KelepourisE, St PeterW, NeumillerJJ, WrightEE: Optimizing multidisciplinary care of patients with chronic kidney disease and type 2 diabetes mellitus. Diabetes Ther 14: 1111–1136, 202310.1007/s13300-023-01416-2PubMed)| false