ANCA-Associated Vasculitis, Anti-GBM Disease, Complement- and Ig-Mediated Glomerular Disease
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Jan Stephan Sanders Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Coen A. Stegeman Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • 1.

    Kronbichler A, Bajema IM, Bruchfeld A, Mastroianni Kirsztajn G, Stone JH: Diagnosis and management of ANCA-associated vasculitis. Lancet 403: 683698, 2024 10.1016/S0140-6736(23)01736-1 PubMed

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  • 2.

    Floege J, Jayne DRW, Sanders J-SF, Tesar V, Rovin BH: KDIGO 2024 clinical practice guideline for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Kidney Int 105: S71S116, 2024 10.1016/j.kint.2023.10.008 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K, et al.: Histopathologic classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol 21: 16281636, 2010 10.1681/ASN.2010050477 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Brix SR, Noriega M, Tennstedt P, Vettorazzi E, Busch M, Nitschke M, et al.: Development and validation of a renal risk score in ANCA-associated glomerulonephritis. Kidney Int 94: 11771188, 2018 10.1016/j.kint.2018.07.020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Bate S, McGovern D, Costigliolo F, Tan PG, Kratky V, Scott J, et al.: The improved kidney risk score in ANCA-associated vasculitis for clinical practice and trials. J Am Soc Nephrol 35: 335346, 2024 10.1681/ASN.0000000000000274 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Sandino-Bermudez MJ, Hernandez-Andrade A, Hinojosa-Azaola A, Martin-Nares E, Mejia-Vilet JM: Performance of clinical and histological prognostic scores for kidney survival in ANCA-associated vasculitis [published online ahead of print Jun 14, 2024]. Rheumatology (Oxford) doi:10.1093/rheumatology/keae336 2024 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Floege J, Jayne DRW, Sanders JF, Tesar V, Balk EM, Gordon CE, et al.: Executive summary of the KDIGO 2024 clinical practice guideline for the management of ANCA-associated vasculitis. Kidney Int 105: 447449, 2024 10.1016/j.kint.2023.10.009 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Hellmich B, Sanchez-Alamo B, Schirmer JH, Berti A, Blockmans D, Cid MC, et al.: EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update. Ann Rheum Dis 83: 3047, 2024 10.1136/ard-2022-223764 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Wallace ZS, Fu X, Cook C, Ahola C, Williams Z, Doliner B, et al.: Comparative effectiveness of rituximab- versus cyclophosphamide-based remission induction strategies in antineutrophil cytoplasmic antibody-associated vasculitis for the risk of kidney failure and mortality. Arthritis Rheumatol 75: 15991607, 2023 10.1002/art.42515 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Ishikawa Y, Tokutsu K, Nakayamada S, Kuchiba A, Fushimi K, Matsuda S, et al.: Short-term effectiveness and safety of rituximab versus cyclophosphamide for life-threatening ANCA-associated vasculitis: A propensity score analysis of the real-world nationwide database. Ann Rheum Dis 83: 103111, 2024 10.1136/ard-2023-224472 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Furuta S, Ikeda K, Nakajima H: Reduced-dose vs high-dose glucocorticoids added to rituximab and remission induction in ANCA-associated vasculitis-reply. JAMA 326: 15361537, 2021 10.1001/jama.2021.13879 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Furuta S, Nakagomi D, Kobayashi Y, Hiraguri M, Sugiyama T, Amano K, et al.; LoVAS collaborators: Reduced-dose versus high-dose glucocorticoids added to rituximab on remission induction in ANCA-associated vasculitis: Predefined 2-year follow-up study. Ann Rheum Dis 83: 96102, 2024 10.1136/ard-2023-224343 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Scherbacher PJ, Hellmich B, Feng YS, Loffler C: Prospective study of complications and sequelae of glucocorticoid therapy in ANCA-associated vasculitis. RMD Open 10: e003956, 2024 10.1136/rmdopen-2023-003956 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Jayne DRW, Merkel PA, Schall TJ, Bekker P, Group AS, ADVOCATE Study Group: Avacopan for the treatment of ANCA-associated vasculitis. N Engl J Med 384: 599609, 2021 10.1056/NEJMoa2023386 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Cortazar FB, Niles JL, Jayne DRW, Merkel PA, Bruchfeld A, Yue H, et al.; ADVOCATE Study Group: Renal recovery for patients with ANCA-associated vasculitis and low eGFR in the ADVOCATE trial of avacopan. Kidney Int Rep 8: 860870, 2023 10.1016/j.ekir.2023.01.039 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Patel NJ, Jayne DRW, Merkel PA, Bekker P, Zhang Y, Yue H, et al.: Glucocorticoid Toxicity Index scores by domain in patients with antineutrophil cytoplasmic antibody-associated vasculitis treated with avacopan versus standard prednisone taper: Post-hoc analysis of data from the ADVOCATE trial. Lancet Rheumatol 5: e130e138, 2023 10.1016/S2665-9913(23)00030-9 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Strand V, Jayne DRW, Horomanski A, Yue H, Bekker P, Merkel PA, et al.; ADVOCATE Study Group: The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: A post-hoc analysis of data from the ADVOCATE trial. Lancet Rheumatol 5: e451e60, 2023 10.1016/S2665-9913(23)00092-9 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Geetha D, Dua A, Yue H, Springer J, Salvarani C, Jayne D, et al.; ADVOCATE Study Group: Efficacy and safety of avacopan in patients with ANCA-associated vasculitis receiving rituximab in a randomised trial. Ann Rheum Dis 83: 223232, 2024 10.1136/ard-2023-224816 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Smith RM, Jones RB, Specks U, Bond S, Nodale M, Al-Jayyousi R, et al.; RITAZAREM co-investigators: Rituximab versus azathioprine for maintenance of remission for patients with ANCA-associated vasculitis and relapsing disease: An international randomised controlled trial. Ann Rheum Dis 82: 937944, 2023 10.1136/ard-2022-223559 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Gabilan C, Belliere J, Moranne O, Pfirmann P, Samson M, Delattre V, et al.: Avacopan for anti-neutrophil cytoplasm antibodies-associated vasculitis: A multicenter real-world study [published online ahead of print Jul 13, 2024]. Rheumatology (Oxford) doi:10.1093/rheumatology/keae359 2024 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21.

    Draibe J, Espigol-Frigole G, Cid MC, Prados MC, Guillen E, Villacorta J, et al.: The real-world use and effectiveness of avacopan in routine practice for the treatment of ANCA vasculitis. First experiences in Spain [published online ahead of print Oct 1, 2024]. Rheumatology (Oxford) doi:10.1093/rheumatology/keae534 2024 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22.

    Walsh M, Merkel PA, Peh CA, Szpirt WM, Puechal X, Fujimoto S, PEXIVAS Investigators, et al.: Plasma exchange and glucocorticoids in severe ANCA-associated vasculitis. N Engl J Med 382: 622631, 2020 10.1056/NEJMoa1803537 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23.

    Walsh M, Collister D, Zeng L et al,: The effects of plasma exchange in patients with ANCA-associated vasculitis: an updated systematic review and meta-analysis. BMJ 376: e064604, 2022.

    • PubMed
    • Export Citation
  • 24.

    Junek ML, Merkel PA, Vilayur E, Wald R, Khalidi N, Jayne D, et al.; PEXIVAS Investigators: Risk of relapse of antineutrophil cytoplasmic antibody-associated vasculitis in a randomized controlled trial of plasma exchange and glucocorticoids. Arthritis Rheumatol 76: 14311438, 2024 10.1002/art.42843 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25.

    Fussner LA, Flores-Suarez LF, Cartin-Ceba R, Specks U, Cox PG, Jayne DRW, et al.; PEXIVAS Investigators: Alveolar hemorrhage in antineutrophil cytoplasmic antibody-associated vasculitis: Results of an international randomized controlled trial (PEXIVAS). Am J Respir Crit Care Med 209: 11411151, 2024 10.1164/rccm.202308-1426OC PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Charles P, Terrier B, Perrodeau E, Cohen P, Faguer S, Huart A, et al.; French Vasculitis Study Group: Comparison of individually tailored versus fixed-schedule rituximab regimen to maintain ANCA-associated vasculitis remission: Results of a multicentre, randomised controlled, phase III trial (MAINRITSAN2). Ann Rheum Dis 77: 11431149, 2018 10.1136/annrheumdis-2017-212878 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27.

    Khoudour N, Delestre F, Jabot-Hanin F, Jouinot A, Nectoux J, Letouneur F, et al.: Association between plasma rituximab concentration and the risk of major relapse in antineutrophil cytoplasmic antibody-associated vasculitides during rituximab maintenance therapy. Arthritis Rheumatol 75: 20032013, 2023 10.1002/art.42556 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28.

    Delestre F, Charles P, Karras A, Pagnoux C, Neel A, Cohen P, et al.; French Vasculitis Study Group (FVSG): Rituximab as maintenance therapy for ANCA-associated vasculitides: Pooled analysis and long-term outcome of 277 patients included in the MAINRITSAN trials. Ann Rheum Dis 83: 233241, 2024 10.1136/ard-2023-224623 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 29.

    Zonozi R, Cortazar FB, Jeyabalan A, Sauvage G, Nithagon P, Huizenga NR, et al.: Maintenance of remission of ANCA vasculitis by rituximab based on B cell repopulation versus serological flare: A randomised trial. Ann Rheum Dis 83: 351359, 2024 10.1136/ard-2023-224489 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 30.

    Renson T, Kelly MM, Benediktsson H, Grundhoefer N, Luca N, Miettunen P, et al.: Non-invasive biomarkers of disease activity and organ damage in ANCA-associated vasculitis: A systematic review. RMD Open 10: e003579, 2024 10.1136/rmdopen-2023-003579 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31.

    Benichou N, Charles P, Terrier B, Jones RB, Hiemstra T, Mouthon L, et al.; French Vasculitis Study Group (FVSG) and European Vasculitis Society (EUVAS) investigators: Proteinuria and hematuria after remission induction are associated with outcome in ANCA-associated vasculitis. Kidney Int 103: 11441155, 2023 10.1016/j.kint.2023.02.029 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 32.

    Prskalo L, Skopnik CM, Goerlich N, Freund P, Wagner L, Grothgar E, et al.: Urinary CD4+ T cells predict renal relapse in ANCA-associated vasculitis. J Am Soc Nephrol 35: 483494, 2024 10.1681/ASN.0000000000000311 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 33.

    Sanchez Alamo B, Moi L, Bajema I, Faurschou M, Flossmann O, Hauser T, et al.; EUVAS: Long-term outcomes and prognostic factors for survival of patients with ANCA-associated vasculitis. Nephrol Dial Transplant 38: 16551665, 2023 10.1093/ndt/gfac320 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 34.

    Sattui SE, Jiang B, Fu X, Cook C, Srivatsan S, Williams ZK, et al.: The effects of age and frailty on the risks of end-stage renal disease, death, and severe infection in older adults with antineutrophil cytoplasmic antibody-associated vasculitis: A retrospective cohort study. Lancet Rheumatol 6: e771e779, 2024 10.1016/S2665-9913(24)00193-0 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35.

    Ponticelli C, Calatroni M, Moroni G: Anti-glomerular basement membrane vasculitis. Autoimmun Rev 22: 103212, 2023 10.1016/j.autrev.2022.103212 PubMed

  • 36.

    Nelveg-Kristensen KE, Madsen B, McClure M, Bruun N, Lyngso C, Dieperink H, et al.; Danish Vasculitis Association (DANVAS): Age- and time-dependent increases in incident anti-glomerular basement membrane disease: A nationwide cohort study. Clin Kidney J 17: sfad261, 2024 10.1093/ckj/sfad261 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 37.

    Zhu M, Wang J, Le W, Xu F, Jin Y, Jiao C, et al.: Relationship between anti-GBM antibodies and kidney outcomes in patients with anti-GBM disease. J Nephrol 36: 789797, 2023 10.1007/s40620-022-01508-5 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 38.

    Segelmark M, Hellmark T, Wieslander J: The prognostic significance in Goodpasture’s disease of specificity, titre and affinity of anti-glomerular-basement-membrane antibodies. Nephron Clin Pract 94: c5968, 2003 10.1159/000072022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 39.

    Floyd L, Bate S, Hadi Kafagi A, Brown N, Scott J, Srikantharajah M, et al.: Risk stratification to predict renal survival in anti-glomerular basement membrane disease. J Am Soc Nephrol 34: 505514, 2023 10.1681/ASN.2022050581 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 40.

    Ge Y, Zhu J, Yang G, Liu K, Yu X, Sun B, et al.: Clinical characteristics and outcome of double-seropositive patients with anti-glomerular basement membrane antibodies and anti-neutrophil cytoplasmic antibodies. Int Immunopharmacol 138: 112607, 2024 10.1016/j.intimp.2024.112607 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 41.

    Kuang H, Jiang N, Jia XY, Cui Z, Zhao MH: Epidemiology, clinical features, risk factors, and outcomes in anti-glomerular basement membrane disease: A systematic review and meta-analysis. Autoimmun Rev 23: 103531, 2024 10.1016/j.autrev.2024.103531 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 42.

    Rovin BH, Adler SG, Barratt J, Bridoux F, Burdge KA, Chan TM, et al.: KDIGO 2021 clinical practice guideline for the management of glomerular diseases. Kidney Int 100: S1S276, 2021 10.1016/j.kint.2021.05.021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 43.

    Sallee M, Resseguier N, Crepin T, Bertin D, Bertrand D, Bobot M, et al.: Immunoadsorption and plasma exchange are comparable in anti-neutrophil cytoplasmic antibodies or anti-glomerular basement membrane removal kinetics. Kidney Int Rep 9: 27672773, 2024 10.1016/j.ekir.2024.06.031 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 44.

    Uhlin F, Szpirt W, Kronbichler A, Bruchfeld A, Soveri I, Rostaing L, et al.: Endopeptidase cleavage of anti-glomerular basement membrane antibodies in vivo in severe kidney disease: An open-label phase 2a study. J Am Soc Nephrol 33: 829838, 2022 10.1681/ASN.2021111460 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 45.

    Bharati J, Yang Y, Sharma P, Jhaveri KD: Atypical anti-glomerular basement membrane disease. Kidney Int Rep 8: 11511161, 2023 10.1016/j.ekir.2023.03.010 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 46.

    Shen CR, Jia XY, Cui Z, Yu XJ, Zhao MH: Clinical and immunological characteristics of patients with combined anti-glomerular basement membrane disease and IgA nephropathy. Clin Kidney J 16: 14801488, 2023 10.1093/ckj/sfad068 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 47.

    Yang XF, Kuang H, Shen CR, Cui Z, Yu XJ, Ma YY, et al.: The prevalence and characteristics of circulating IgA anti-glomerular basement membrane autoantibodies in anti-glomerular basement membrane disease. Kidney Int Rep 8: 23952402, 2023 10.1016/j.ekir.2023.08.029 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 48.

    Bu L, Said SM, Herrera Hernandez L, Taheri Z, Spry L, Rosenthal BS, et al.: The characteristics of concurrent anti-glomerular basement membrane nephritis and membranous nephropathy. Kidney Int Rep 8: 21642167, 2023 10.1016/j.ekir.2023.07.031 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 49.

    Yu SM, Deoliveira M, Chung M, Lafayette R: Membranoproliferative glomerulonephritis pattern of injury. Adv Kidney Dis Health 31: 216222, 2024 10.1053/j.akdh.2024.03.005 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 50.

    Vivarelli M, Barratt J, Beck LH Jr, Fakhouri F, Gale DP, Goicoechea de JE, et al.; for Conference Participants: The role of complement in kidney disease: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int 106: 369391, 2024 10.1016/j.kint.2024.05.015 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 51.

    Fakhouri F, Le QM, Fremeaux-Bacchi V: Practical management of C3 glomerulopathy and Ig-mediated MPGN: Facts and uncertainties. Kidney Int 98: 11351148, 2020 10.1016/j.kint.2020.05.053 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 52.

    Roquigny J, Meuleman MS, El SC, Martins PV, Meri S, Duval A, et al.: Acquired and genetic drivers of C3 and C5 convertase dysregulation in C3 glomerulopathy and immunoglobulin-associated MPGN [published online ahead of print Nov 13, 2024]. Nephrol DialTransplant doi:10.1093/ndt/gfae243 2024 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 53.

    Meuleman MS, Vieira-Martins P, El SC, Audard V, Baudouin V, Bertrand D, et al.: Rare variants in complement gene in C3 glomerulopathy and immunoglobulin-mediated membranoproliferative GN. Clin J Am Soc Nephrol 18: 14351445, 2023 10.2215/CJN.0000000000000252 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 54.

    Ravindran A, Fervenza FC, Smith RJH, Sethi S: C3 glomerulopathy associated with monoclonal Ig is a distinct subtype. Kidney Int 94: 178186, 2018 10.1016/j.kint.2018.01.037 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 55.

    Chauvet S, Fremeaux-Bacchi V, Petitprez F, Karras A, Daniel L, Burtey S, et al.: Treatment of B-cell disorder improves renal outcome of patients with monoclonal gammopathy-associated C3 glomerulopathy. Blood 129: 14371447, 2017 10.1182/blood-2016-08-737163 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 56.

    Hauer JJ, Zhang Y, Goodfellow R, Taylor A, Meyer NC, Roberts S, et al.: Defining nephritic factors as diverse drivers of systemic complement dysregulation in C3 glomerulopathy. Kidney Int Rep 9: 464477, 2024 10.1016/j.ekir.2023.11.025 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 57.

    Wada Y, Kamata M, Miyasaka R, Abe T, Kawamura S, Takeuchi K, et al.: Clinico-pathogenic similarities and differences between infection-related glomerulonephritis and C3 glomerulopathy. Int J MolSci 24: 8432, 2023 10.3390/ijms24098432 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 58.

    Rovin BH, Adler SG, Barratt J, Bridoux F, Burdge KA, Chan TM, et al.: Executive summary of the KDIGO 2021 guideline for the management of glomerular diseases. Kidney Int 100: 753779, 2021 10.1016/j.kint.2021.05.015 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 59.

    Ahn W: Primary Nephritic Syndromes (IgA Nephropathy and Complement- and Ig-Mediated Glomerular Disease with MPGN Histology). NephSAP21: 352363, 2022 10.1681/nsap.00462022

    • PubMed
    • Export Citation
  • 60.

    Wooden B, Nester CM, Bomback AS: Update on C3 glomerulopathy. Adv Kidney Dis Health 31: 223233, 2024 10.1053/j.akdh.2024.05.002 PubMed

  • 61.

    Noris M, Remuzzi G: C3G and Ig-MPGN-treatment standard. Nephrol Dial Transplant 39: 202214, 2024 10.1093/ndt/gfad182 PubMed

  • 62.

    Caravaca-Fontan F, Diaz-Encarnacion MM, Lucientes L, Cavero T, Cabello V, Ariceta G, et al.; on behalf of the Spanish Group for the Study of Glomerular Diseases GLOSEN: Mycophenolate mofetil in C3 glomerulopathy and pathogenic drivers of the disease. CJASN 15: 12871298, 2020 10.2215/CJN.15241219 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 63.

    Caravaca-Fontan F, Cavero T, Diaz-Encarnacion M, Cabello V, Ariceta G, Quintana LF, et al.; Spanish Group for the Study of Glomerular Diseases (GLOSEN): Clinical profiles and patterns of kidney disease progression in C3 glomerulopathy. Kidney360 4: 659672, 2023 10.34067/KID.0000000000000115 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 64.

    Khandelwal P, Bhardwaj S, Singh G, Sinha A, Hari P, Bagga A: Therapy and outcomes of C3 glomerulopathy and immune-complex membranoproliferative glomerulonephritis. Pediatr Nephrol 36: 591600, 2021 10.1007/s00467-020-04736-8 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 65.

    Lomax-Browne HJ, Medjeral-Thomas NR, Barbour SJ, Gisby J, Han H, Bomback AS, et al.: Association of histologic parameters with outcome in C3 glomerulopathy and idiopathic immunoglobulin-associated membranoproliferative glomerulonephritis. Clin J Am Soc Nephrol 17: 9941007, 2022 10.2215/CJN.16801221 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 66.

    Bomback AS, Herlitz LC, Kedia PP, Petersen J, Yue H, Lafayette RA: Safety and efficacy of avacopan in patients with C3 glomerulopathy: Randomized, double-blind clinical trial [published online ahead of print Oct 11, 2024]. J Am Soc Nephrol doi:10.1681/ASN.0000000526 2024 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 67.

    Bomback AS, Santoriello D, et al.: C3 glomerulonephritis and dense deposit disease share a similar disease course in a large United States cohort of patients with C3 glomerulopathy. Kidney Int 93: 977985, 2018 10.1016/j.kint.2017.10.022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 68.

    Caravaca-Fontán F, Trujillo H, Alonso M, Díaz-Encarnación M, Cabello V, Ariceta G, et al.; C3G Study Group of the Spanish Group for the Study of Glomerular Diseases (GLOSEN): Validation of a histologic scoring index for C3 glomerulopathy. Am J Kidney Dis 77: 684695.e1, 2021 10.1053/j.ajkd.2020.11.011 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 69.

    Wong E, Nester C, Cavero T, Karras A, Le QM, Lightstone L, et al.: Efficacy and safety of iptacopan in patients with C3 glomerulopathy. Kidney Int Rep 8: 27542764, 2023 10.1016/j.ekir.2023.09.017 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 70.

    Smith RJ, Kavanagh D, Vivarelli M, al el.: Efficacy and safety of iptacopan in patients with C3 glomerulopathy: 12-month results from the phase 3 APPEAR-C3G study. J Am Soc Nephrol 35: 10.1681/ASN.2024f5gka890, 2024 10.1681/ASN.2024f5gka890

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 71.

    Dixon BP, Greenbaum LA, Huang L, Rajan S, Ke C, Zhang Y, et al.: Clinical safety and efficacy of pegcetacoplan in a phase 2 study of patients with C3 glomerulopathy and other complement-mediated glomerular diseases. Kidney Int Rep 8: 22842293, 2023 10.1016/j.ekir.2023.08.033 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 72.

    Nester CM, Bomback AS, Ariceta Iraola MG, al el.: VALIANT: A randomized, multicenter, double-blind, placebo (PBO)-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent glomerulopathy (C3G) or primary immune complex membranoproliferative glomerulonephritis (IC-MPGN). J Am Soc Nephrol 35: 10.1681/ASN.2024qdwvz5bg, 2024 10.1681/ASN.2024qdwvz5bg PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 73.

    Caravaca-Fontan F, Lucientes L, Serra N, Cavero T, Rodado R, Ramos N, et al.: C3 glomerulopathy associated with monoclonal gammopathy: Impact of chronic histologic lesions and beneficial effects of clone-targeted therapies. Nephrol Dial Transplant 37: 21282137, 2022 10.1093/ndt/gfab302 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 74.

    Verbinnen M, Sprangers B, Abrahams AC, Koshy P, Van Kruijsdijk RCM, Philipse E, et al.: Proliferative glomerulonephritis with monoclonal immunoglobulin deposits in the native or posttransplant kidney. Nephrol Dial Transplant 39: 888892, 2024 10.1093/ndt/gfae005 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 75.

    Zand L, Rajkumar SV, Leung N, Sethi S, El Ters M, Fervenza FC: Safety and efficacy of daratumumab in patients with proliferative GN with monoclonal immunoglobulin deposits. J Am Soc Nephrol 32: 11631173, 2021 10.1681/ASN.2020101541 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 76.

    Coltoff A, Bomback A, Shirazian S, Lentzsch S, Bhutani D: Treatment of monoclonal gammopathy-associated C3 glomerulopathy with daratumumab-based therapy. Clin Lymphoma Myeloma Leuk 21: e674e7, 2021 10.1016/j.clml.2021.04.011 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 77.

    Svabova E, Zieg J, Sukova M, Flachsova E, Kment M, Tesar V: Proliferative glomerulonephritis with monoclonal IgG deposits in an adolescent successfully treated with daratumumab. Pediatr Nephrol 39: 34553457, 2024 10.1007/s00467-024-06425-2 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 78.

    Giang S, Agrawal AK, Oates A: Daratumumab therapy in a pediatric case of C3 nephritic factor-positive proliferative glomerulonephritis with monoclonal IgG deposits. CEN Case Rep 13: 429433, 2024 10.1007/s13730-024-00868-0 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 79.

    Nester CM, Feldman DL, Burwick R, Cataland S, Chaturvedi S, Cook HT, et al.: An expert discussion on the atypical hemolytic uremic syndrome nomenclature-identifying a road map to precision: A report of a National Kidney Foundation Working Group. Kidney Int 106: 326336, 2024 10.1016/j.kint.2024.05.021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 80.

    Khandelwal P, Nambiar S, Saini R, Saini S, Coshic P, Sinha A, et al.: Anti-factor B antibodies in atypical hemolytic uremic syndrome. Pediatr Nephrol 39: 19091916, 2024 10.1007/s00467-024-06284-x PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 81.

    Obata S, Hullekes F, Riella LV, Cravedi P: Recurrent complement-mediated Hemolytic uremic syndrome after kidney transplantation. Transplant Rev (Orlando) 38: 100857, 2024 10.1016/j.trre.2024.100857 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 82.

    Duineveld C, Bouwmeester RN, Wijnsma KL, Bemelman FJ, van der Heijden JW, Berger SP, et al.; Dutch aHUS Working Group: Eculizumab rescue therapy in patients with recurrent atypical hemolytic uremic syndrome after kidney transplantation. Kidney Int Rep 8: 715726, 2023 10.1016/j.ekir.2023.01.016 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 83.

    Schaefer F, Al-Dakkak I, Anokhina K, Cohen D, Greenbaum LA, Ariceta G: Global aHUS Registry analysis of patients switching to ravulizumab from eculizumab. Kidney Int Rep 9: 26482656, 2024 10.1016/j.ekir.2024.06.020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation

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