IgA Nephropathy and Glomerular Diseases Associated with Infection
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Patrick J. Gleeson Hôpital Bichat - Claude-Bernard, Paris, France

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Jonathan Barratt University of Leicester, Leicester, United Kingdom

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  • 1.

    Gleeson PJ, O’Shaughnessy MM, Barratt J: IgA nephropathy in adults-treatment standard. Nephrol Dial Transplant 38: 24642473, 2023 10.1093/ndt/gfad146 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Nasr SH, Markowitz GS, Whelan JD, Albanese JJ, Rosen RM, Fein DA, et al.: IgA-dominant acute poststaphylococcal glomerulonephritis complicating diabetic nephropathy. Hum Pathol 34: 12351241, 2003 10.1016/s0046-8177(03)00424-6 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Nasr SH, D’Agati VD: IgA-dominant postinfectious glomerulonephritis: A new twist on an old disease. Nephron Clin Pract 119: c1825; discussion c26, 2011 10.1159/000324180 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Nasr SH, Radhakrishnan J, D’Agati VD: Bacterial infection-related glomerulonephritis in adults. Kidney Int 83: 792803, 2013 10.1038/ki.2012.407 PubMed

  • 5.

    Moriyama T, Karasawa K, Miyabe Y, Akiyama K, Ogura S, Takabe T, et al.: Validation of the revised Oxford classification for IgA nephropathy considering treatment with corticosteroids/immunosuppressors. Sci Rep 10: 11151, 2020 10.1038/s41598-020-68087-y PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Moriyama T, Tanaka K, Iwasaki C, Oshima Y, Ochi A, Kataoka H, et al.: Prognosis in IgA nephropathy: 30-year analysis of 1,012 patients at a single center in Japan. PLoS One 9: e91756, 2014 10.1371/journal.pone.0091756 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    D’Amico G: Natural history of idiopathic IgA nephropathy and factors predictive of disease outcome. Semin Nephrol 24: 179196, 2004 10.1016/j.semnephrol.2004.01.001 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Coppo R: Pediatric IgA Nephropathy in Europe. Kidney Dis (Basel) 5: 182188, 2019 10.1159/000495751 PubMed

  • 9.

    Sevillano AM, Diaz M, Caravaca-Fontán F, Barrios C, Bernis C, Cabrera J, et al.; Spanish Group for the Study of Glomerular Diseases (GLOSEN): IgA nephropathy in elderly patients. Clin J Am Soc Nephrol 14: 11831192, 2019 10.2215/CJN.13251118 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Glassock RJ: Anticoagulant-related nephropathy: It’s the real McCoy. Clin J Am Soc Nephrol 14: 935937, 2019 10.2215/CJN.02470319 PubMed

  • 11.

    Willey CJ, Coppo R, Schaefer F, Mizerska-Wasiak M, Mathur M, Schultz MJ: The incidence and prevalence of IgA nephropathy in Europe. Nephrol Dial Transplant 38: 23402349, 2023 10.1093/ndt/gfad082 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Kiryluk K, Freedberg DE, Radhakrishnan J, Segall L, Jacobson JS, Mathur M, et al.: Global incidence of IgA nephropathy by race and ethnicity: A systematic review. Kidney360 4: 11121122, 2023 10.34067/KID.0000000000000165 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Barbour SJ, Cattran DC, Kim SJ, Levin A, Wald R, Hladunewich MA, et al.: Individuals of Pacific Asian origin with IgA nephropathy have an increased risk of progression to end-stage renal disease. Kidney Int 84: 10171024, 2013 10.1038/ki.2013.210 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    O’Shaughnessy MM, Hogan SL, Poulton CJ, Falk RJ, Singh HK, Nickeleit V, et al.: Temporal and demographic trends in glomerular disease epidemiology in the southeastern United States, 1986–2015. Clin J Am Soc Nephrol 12: 614623, 2017 10.2215/CJN.10871016 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Caster DJ, Abner CW, Walker PD, Wang K, Heo J, Rava AR, et al.: Clinicopathological characteristics of adult IgA nephropathy in the United States. Kidney Int Rep 8: 17921800, 2023 10.1016/j.ekir.2023.06.016 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Satoskar AA, Parikh SV, Nadasdy T: Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis. Nat Rev Nephrol 16: 3250, 2020 10.1038/s41581-019-0178-8 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Kanjanabuch T, Kittikowit W, Eiam-Ong S: An update on acute postinfectious glomerulonephritis worldwide. Nat Rev Nephrol 5: 259269, 2009 10.1038/nrneph.2009.44 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Nasr SH, Fidler ME, Valeri AM, Cornell LD, Sethi S, Zoller A, et al.: Postinfectious glomerulonephritis in the elderly. J Am Soc Nephrol 22: 187195, 2011 10.1681/ASN.2010060611 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Suzuki H, Kiryluk K, Novak J, Moldoveanu Z, Herr AB, Renfrow MB, et al.: The pathophysiology of IgA nephropathy. J Am Soc Nephrol 22: 17951803, 2011 10.1681/ASN.2011050464 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Nihei Y, Haniuda K, Higashiyama M, Asami S, Iwasaki H, Fukao Y, et al.: Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy. Sci Adv 9: eadd6734, 2023 10.1126/sciadv.add6734 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21.

    Tomana M, Matousovic K, Julian BA, Radl J, Konecny K, Mestecky J: Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG. Kidney Int 52: 509516, 1997 10.1038/ki.1997.361 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22.

    Berger J, Yaneva H, Nabarra B, Barbanel C: Recurrence of mesangial deposition of IgA after renal transplantation. Kidney Int 7: 232241, 1975 10.1038/ki.1975.35 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23.

    Cambier A, Gleeson PJ, Abbad L, Canesi F, da Silva J, Bex-Coudrat J, et al.: Soluble CD89 is a critical factor for mesangial proliferation in childhood IgA nephropathy. Kidney Int 101: 274287, 2022 10.1016/j.kint.2021.09.023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24.

    Silva FG, Chander P, Pirani CL, Hardy MA: Disappearance of glomerular mesangial IgA deposits after renal allograft transplantation. Transplantation 33: 241246, 1982 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25.

    Chou Y-L, Chen H-L, Hsu B-G, Yang C-Y, Chen C-H, Lee Y-C, et al.: Galectin-3 contributes to pathogenesis of IgA nephropathy. Kidney Int 106: 658670, 2024 10.1016/j.kint.2024.06.023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Makita Y, Suzuki H, Kano T, Takahata A, Julian BA, Novak J, et al.: TLR9 activation induces aberrant IgA glycosylation via APRIL- and IL-6-mediated pathways in IgA nephropathy. Kidney Int 97: 340349, 2020 10.1016/j.kint.2019.08.022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27.

    Zhu Y, He H, Sun W, Wu J, Xiao Y, Peng Y, et al.: IgA nephropathy: Gut microbiome regulates the production of hypoglycosilated IgA1 via the TLR4 signaling pathway. Nephrol Dial Transplant 39: 16241641, 2024 10.1093/ndt/gfae052 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28.

    Levy M: Cas familiaux de maladie de Berger ou de maladie de Berger et de purpura rhumatoide. Etude cooperative de la Societe Francaise de Nephrologie [Familial cases of Berger’s disease or of Berger’s disease and rheumatoid purpura. Cooperative study of the Societe Francaise de Nephrologie]. Nephrologie 10: 175182, 1989 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 29.

    Julian BA, Quiggins PA, Thompson JS, Woodford SY, Gleason K, Wyatt RJ: Familial IgA nephropathy. Evidence of an inherited mechanism of disease. N Engl J Med 312: 202208, 1985 10.1056/NEJM198501243120403 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 30.

    Karnib HH, Sanna-Cherchi S, Zalloua PA, Medawar W, D’Agati VD, Lifton RP, et al.: Characterization of a large Lebanese family segregating IgA nephropathy. Nephrol Dial Transplant 22: 772777, 2007 10.1093/ndt/gfl677 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31.

    O’Connell PJ, Ibels LS, Thomas MA, Harris M, Eckstein RP: Familial IgA nephropathy: A study of renal disease in an Australian aboriginal family. Aust N Z J Med 17: 2733, 1987 10.1111/j.1445-5994.1987.tb05045.x PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 32.

    Magistroni R, D’Agati VD, Appel GB, Kiryluk K: New developments in the genetics, pathogenesis, and therapy of IgA nephropathy. Kidney Int 88: 974989, 2015 10.1038/ki.2015.252 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 33.

    Scolari F, Amoroso A, Savoldi S, Mazzola G, Prati E, Valzorio B, et al.: Familial clustering of IgA nephropathy: Further evidence in an Italian population. Am J Kidney Dis 33: 857865, 1999 10.1016/s0272-6386(99)70417-8 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 34.

    Tsuboi N, Kawamura T, Okonogi H, Ishii T, Utsunomiya Y, Hosoya T: Discordant clinicopathological features in monozygotic twins with IgA nephropathy. Nephrol Dial Transplant 26: 41464148, 2011 10.1093/ndt/gfr519 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35.

    Masuda J, Shiiki H, Fujii Y, Dohi K, Harada A: [Identical twin sisters with IgA nephropathy]. Nihon Jinzo Gakkai Shi 38: 5256, 1996 PubMed

  • 36.

    Irvine J, Cross N, Lynn K, Robson R, Searle M, Morton J, et al.: IgA nephropathy in identical twins: An excellent donor and recipient outcome 11 years after transplantation. Clin Kidney J 5: 232233, 2012 10.1093/ckj/sfs022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 37.

    Ahlmen J, Hedman I, Svalander C: Recurrent IgA-nephropathy in an identical twin transplant. Clin Transpl 1989: 297, 1989 PubMed

  • 38.

    Wei M, Meng S, Shi S, Liu L, Zhou X, Lv J, et al.: Monozygotic twins discordant for immunoglobulin A nephropathy display differences in DNA methylation and gene expression. Kidney Dis (Basel) 7: 200209, 2021 10.1159/000512169 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 39.

    Feehally J, Farrall M, Boland A, Gale DP, Gut I, Heath S, et al.: HLA has strongest association with IgA nephropathy in genome-wide analysis. J Am Soc Nephrol 21: 17911797, 2010 10.1681/ASN.2010010076 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 40.

    Gharavi AG, Kiryluk K, Choi M, Li Y, Hou P, Xie J, et al.: Genome-wide association study identifies susceptibility loci for IgA nephropathy. Nat Genet 43: 321327, 2011 10.1038/ng.787 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 41.

    Yu X-Q, Li M, Zhang H, Low H-Q, Wei X, Wang J-Q, et al.: A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. Nat Genet 44: 178182, 2011 10.1038/ng.1047 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 42.

    Kiryluk K, Li Y, Scolari F, Sanna-Cherchi S, Choi M, Verbitsky M, et al.: Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. Nat Genet 46: 11871196, 2014 10.1038/ng.3118 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 43.

    Li M, Foo J-N, Wang J-Q, Low H-Q, Tang X-Q, Toh K-Y, et al.: Identification of new susceptibility loci for IgA nephropathy in Han Chinese. Nat Commun 6: 7270, 2015 10.1038/ncomms8270 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 44.

    Li M, Wang L, Shi D-C, Foo J-N, Zhong Z, Khor C-C, et al.: Genome-wide meta-analysis identifies three novel susceptibility loci and reveals ethnic heterogeneity of genetic susceptibility for IgA nephropathy. J Am Soc Nephrol 31: 29492963, 2020 10.1681/ASN.2019080799 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 45.

    Kiryluk K, Sanchez-Rodriguez E, Zhou X-J, Zanoni F, Liu L, Mladkova N, et al.: Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy. Nat Genet 55: 10911105, 2023 10.1038/s41588-023-01422-x PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 46.

    Li M, Wang Y-N, Wang L, Meah W-Y, Shi D-C, Heng K-K, et al.: Genome-wide association analysis of protein-coding variants in IgA nephropathy. J Am Soc Nephrol 34: 19001913, 2023 10.1681/ASN.0000000000000222 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 47.

    Gleeson PJ, Benech N, Chemouny J, Metallinou E, Berthelot L, da Silva J, et al.: The gut microbiota posttranslationally modifies IgA1 in autoimmune glomerulonephritis. Sci Transl Med 16: eadl6149, 2024 10.1126/scitranslmed.adl6149 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 48.

    Liang X, Zhang S, Zhang D, Hu L, Zhang L, Peng Y, et al.: Metagenomics-based systematic analysis reveals that gut microbiota Gd-IgA1-associated enzymes may play a key role in IgA nephropathy. Front Mol Biosci 9: 970723, 2022 10.3389/fmolb.2022.970723 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 49.

    Breban M, Tap J, Leboime A, Said-Nahal R, Langella P, Chiocchia G, et al.: Faecal microbiota study reveals specific dysbiosis in spondyloarthritis. Ann Rheum Dis 76: 16141622, 2017 10.1136/annrheumdis-2016-211064 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 50.

    Dong R, Bai M, Zhao J, Wang D, Ning X, Sun S: A comparative study of the gut microbiota associated with immunoglobulin a nephropathy and membranous nephropathy. Front Cell Infect Microbiol 10: 557368, 2020 10.3389/fcimb.2020.557368 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 51.

    Ren Z, Fan Y, Li A, Shen Q, Wu J, Ren L, et al.: Alterations of the human gut microbiome in chronic kidney disease. Adv Sci (Weinh) 7: 2001936, 2020 10.1002/advs.202001936 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 52.

    Zhao J, Bai M, Ning X, Qin Y, Wang Y, Yu Z, et al.: Expansion of Escherichia-Shigella in gut is associated with the onset and response to immunosuppressive therapy of IgA nephropathy. J Am Soc Nephrol 33: 22762292, 2022 10.1681/ASN.2022020189 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 53.

    Zhao J, Bai M, Yang X, Wang Y, Li R, Sun S: Alleviation of refractory IgA nephropathy by intensive fecal microbiota transplantation: The first case reports. Ren Fail 43: 928933, 2021 10.1080/0886022X.2021.1936038 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 54.

    Zhang M, Zhou W, Liu S, Zhang L, Ni Z, Hao C: KM55 monoclonal antibody staining in IgA-dominant infection-related glomerulonephritis. Nephron 145: 225237, 2021 10.1159/000513269 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 55.

    Hirayama K, Kobayashi M, Kondoh M, Muro K, Iwabuchi S, Yoh K, et al.: Henoch-Schonlein purpura nephritis associated with methicillin-resistant Staphylococcus aureus infection. Nephrol Dial Transplant 13: 27032704, 1998 10.1093/ndt/13.10.2703 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 56.

    Chauvet S, Berthaud R, Devriese M, Mignotet M, Vieira Martins P, Robe-Rybkine T, et al.: Anti-factor B antibodies and acute postinfectious GN in children. J Am Soc Nephrol 31: 829840, 2020 10.1681/ASN.2019080851 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 57.

    Carter SA, Gutman T, Logeman C, Cattran D, Lightstone L, Bagga A, et al.; SONG-GD Investigators: Identifying Outcomes Important to Patients with Glomerular Disease and Their Caregivers. Clin J Am Soc Nephrol 15: 673684, 2020 10.2215/CJN.13101019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 58.

    Kerklaan J, Hannan E, Hanson C, Guha C, Cho Y, Christian M, et al.: Perspectives on life participation by young adults with chronic kidney disease: An interview study. BMJ Open 10: e037840, 2020 10.1136/bmjopen-2020-037840 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 59.

    Jhaveri KD, Bensink ME, Bunke M, Briggs JA, Cork DMW, Jeyabalan A: Humanistic and economic burden of IgA nephropathy: Systematic literature reviews and narrative synthesis. Pharmacoecon Open 7: 709722, 2023 10.1007/s41669-023-00415-0 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 60.

    Szklarzewicz J, Floege U, Gallego D, Gibson K, Kalantar-Zadeh K, Helm K, et al.: The humanistic burden of immunoglobulin A nephropathy on patients and care-partners in the United States. Qual Life Res, 2024 10.1007/s11136-024-03813-x PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 61.

    Yang N, Tang J, Li X, Li D, Zhu B, He Q, et al.: A patient report scale research to access the symptom burden in patients with IgA nephropathy. Sci Rep 14: 22104, 2024 10.1038/s41598-024-59586-3 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 62.

    Barbour SJ, Espino-Hernandez G, Reich HN, Coppo R, Roberts ISD, Feehally J, et al.; Oxford Derivation North American Validation and VALIGA Consortia: The MEST score provides earlier risk prediction in lgA nephropathy. Kidney Int 89: 167175, 2016 10.1038/ki.2015.322 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 63.

    Pitcher D, Braddon F, Hendry B, Mercer A, Osmaston K, Saleem MA, et al.: Long-term outcomes in IgA nephropathy. Clin J Am Soc Nephrol 18: 727738, 2023 10.2215/CJN.0000000000000135 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 64.

    Jarrick S, Lundberg S, Welander A, Carrero J-J, Höijer J, Bottai M, et al.: Mortality in IgA nephropathy: A nationwide population-based cohort study. J Am Soc Nephrol 30: 866876, 2019 10.1681/ASN.2018101017 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 65.

    Lee H, Kim DK, Oh K-H, Joo KW, Kim YS, Chae D-W, et al.: Mortality of IgA nephropathy patients: A single center experience over 30 years. PLoS One 7: e51225, 2012 10.1371/journal.pone.0051225 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 66.

    Glassock RJ: Mortality Risk in IgA Nephropathy. J Am Soc Nephrol 30: 720722, 2019 10.1681/ASN.2018121255 PubMed

  • 67.

    Sevillano AM, Caravaca-Fontán F, Cordero Garcia-Galan L, Fernandez-Juarez G, Lopez-Revuelta K, Guzmán DA, et al.; Spanish Group for the Study of Glomerular Diseases (GLOSEN): Effect of immunosuppressive treatments on kidney outcomes after gross hematuria-related acute kidney injury in older patients with IgA nephropathy. Kidney Int Rep 8: 15961604, 2023 10.1016/j.ekir.2023.05.027 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 68.

    Huang Z, Chen B, Zhou Y, Liang Y, Qiu W, Lv Y, et al.: Clinicopathological and prognostic study of IgA-dominant postinfectious glomerulonephritis. BMC Nephrol 22: 248, 2021 10.1186/s12882-021-02462-3 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 69.

    Barbour SJ, Coppo R, Zhang H, Liu Z-H, Suzuki Y, Matsuzaki K, et al.; International IgA Nephropathy Network: Evaluating a New International Risk-Prediction Tool in IgA Nephropathy. JAMA Intern Med 179: 942952, 2019 10.1001/jamainternmed.2019.0600 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 70.

    Rovin BH, Adler SG, Barratt J, Bridoux F, Burdge KA, Chan TM, et al.: KDIGO 2021 clinical practice guideline for the management of glomerular diseases. Kidney Int 100: S1S276, 2021 10.1016/j.kint.2021.05.021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 71.

    Barbour SJ, Coppo R, Er L, Russo ML, Liu Z-H, Ding J, et al.; International IgA Nephropathy Network Research Group: Application of the updated International IgA Nephropathy Prediction Tool in children one or two years post-biopsy. Kidney Int 106: 913927, 2024 10.1016/j.kint.2024.07.012 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 72.

    Barbour SJ, Coppo R, Er L, Russo ML, Liu Z-H, Ding J, et al.; International IgA Nephropathy Network: Updating the International IgA Nephropathy Prediction Tool for use in children. Kidney Int 99: 14391450, 2021 10.1016/j.kint.2020.10.033 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 73.

    Bellur SS, Troyanov S, Vorobyeva O, Coppo R, Roberts ISD, Validation in IgAN Study Group: Evidence from the large VALIGA cohort validates the subclassification of focal segmental glomerulosclerosis in IgA nephropathy. Kidney Int 105: 12791290, 2024 10.1016/j.kint.2024.03.011 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 74.

    Wada Y, Matsumoto K, Suzuki T, Saito T, Kanazawa N, Tachibana S, et al.: Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy. PLoS One 13: e0206865, 2018 10.1371/journal.pone.0206865 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 75.

    Maixnerova D, Ling C, Hall S, Reily C, Brown R, Neprasova M, et al.: Galactose-deficient IgA1 and the corresponding IgG autoantibodies predict IgA nephropathy progression. PLoS One 14: e0212254, 2019 10.1371/journal.pone.0212254 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 76.

    Martín-Penagos L, Fernández-Fresnedo G, Benito-Hernández A, Mazón J, de Cos M, Oviedo MV, et al.: Measurement of galactosyl-deficient IgA1 by the monoclonal antibody KM55 contributes to predicting patients with IgA nephropathy with high risk of long-term progression. Nefrologia (Engl Ed) 41: 311320, 2021 10.1016/j.nefroe.2021.06.004 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 77.

    Berthoux F, Suzuki H, Thibaudin L, Yanagawa H, Maillard N, Mariat C, et al.: Autoantibodies targeting galactose-deficient IgA1 associate with progression of IgA nephropathy. J Am Soc Nephrol 23: 15791587, 2012 10.1681/ASN.2012010053 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 78.

    Maeda A, Gohda T, Funabiki K, Horikoshi S, Shirato I, Tomino Y: Significance of serum IgA levels and serum IgA/C3 ratio in diagnostic analysis of patients with IgA nephropathy. J Clin Lab Anal 17: 7376, 2003 10.1002/jcla.10071 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 79.

    Gong W-Y, Liu M, Luo D, Liu F-N, Yin L-H, Li Y-Q, et al.: High serum IgA/C3 ratio better predicts a diagnosis of IgA nephropathy among primary glomerular nephropathy patients with proteinuria </= 1 g/d: An observational cross-sectional study. BMC Nephrol 20: 150, 2019 10.1186/s12882-019-1331-0 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 80.

    Liu L, Zhang Y, Duan X, Peng Q, Liu Q, Zhou Y, et al.: C3a, C5a renal expression and their receptors are correlated to severity of IgA nephropathy. J Clin Immunol 34: 224232, 2014 10.1007/s10875-013-9970-6 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 81.

    Torres DD, Rossini M, Manno C, Mattace-Raso F, D’Altri C, Ranieri E, et al.: The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the urine predicts renal prognosis in IgA nephropathy. Kidney Int 73: 327333, 2008 10.1038/sj.ki.5002621 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 82.

    Hisano S, Joh K, Katafuchi R, Shimizu A, Hashiguchi N, Kawamura T, et al.; Ministry of Health, Labor and Welfare of Japan: Reproducibility for pathological prognostic parameters of the Oxford classification of IgA nephropathy: The authors reply. Clin Exp Nephrol 21: 11371138, 2017 10.1007/s10157-017-1422-9 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 83.

    Gong S, Jin S, Li Y, Jiang W, Zhang Z, Shen Z, et al.: Urinary soluble CD163 levels predict IgA nephropathy remission status. Front Immunol 12: 769802, 2021 10.3389/fimmu.2021.769802 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 84.

    Li J, Lv J, Wong MG, Shi S, Zan J, Monaghan H, TESTING Study Biomarker Group, et al.: Correlation of urinary soluble CD163 levels with disease activity and treatment response in IgA nephropathy. Kidney Int Rep 9: 30163026, 2024 10.1016/j.ekir.2024.07.031 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 85.

    Ștefan G, Jullien P, Masson I, Alamartine E, Mariat C, Maillard N: Circulating alternative pathway complement cleavage factor Bb is associated with vascular lesions and outcomes in IgA nephropathy. Nephrol Dial Transplant 38: ii11ii18, 2023 10.1093/ndt/gfad163 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 86.

    Medjeral-Thomas NR, Cook HT, Pickering MC: Complement activation in IgA nephropathy. Semin Immunopathol 43: 679690, 2021 10.1007/s00281-021-00882-9 PubMed

  • 87.

    Paueksakon P, Najafian B, Alpers CE, Fogo AB: AJKD atlas of renal pathology: IgA-dominant infection-related glomerulonephritis. Am J Kidney Dis 83: e1e2, 2024 10.1053/j.ajkd.2023.05.009 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 88.

    Xie D, Zhao H, Xu X, Zhou Z, Su C, Jia N, et al.: Intensity of macrophage infiltration in glomeruli predicts response to immunosuppressive therapy in patients with IgA nephropathy. J Am Soc Nephrol 32: 31873196, 2021 10.1681/ASN.2021060815 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 89.

    Yoshimura M, Kida H, Abe T, Takeda S, Katagiri M, Hattori N: Significance of IgA deposits on the glomerular capillary walls in IgA nephropathy. Am J Kidney Dis 9: 404409, 1987 10.1016/s0272-6386(87)80143-9 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 90.

    Fogo AB, Lusco MA, Najafian B, Alpers CE: AJKD atlas of renal pathology: IgA nephropathy. Am J Kidney Dis 66: e33-4e34, 2015 10.1053/j.ajkd.2015.08.001 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 91.

    Brodsky SV, Nadasdy T, Cassol C, Satoskar A: IgA staining patterns differentiate between IgA nephropathy and IgA-dominant infection-associated glomerulonephritis. Kidney Int Rep 5: 909911, 2020 10.1016/j.ekir.2020.03.029 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 92.

    Reich HN, Troyanov S, Scholey JW, Cattran DC, Toronto Glomerulonephritis Registry: Remission of proteinuria improves prognosis in IgA nephropathy. J Am Soc Nephrol 18: 31773183, 2007 10.1681/ASN.2007050526 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 93.

    Praga M, Gutierrez E, Gonzalez E, Morales E, Hernandez E: Treatment of IgA nephropathy with ACE inhibitors: A randomized and controlled trial. J Am Soc Nephrol 14: 15781583, 2003 10.1097/01.asn.0000068460.37369.dc PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 94.

    Li PK-T, Leung CB, Chow KM, Cheng YL, Fung SK-S, Mak SK, et al.; HKVIN Study Group: Hong Kong study using valsartan in IgA nephropathy (HKVIN): A double-blind, randomized, placebo-controlled study. Am J Kidney Dis 47: 751760, 2006 10.1053/j.ajkd.2006.01.017 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 95.

    Inker LA, Mondal H, Greene T, Masaschi T, Locatelli F, Schena FP, et al.: Early change in urine protein as a surrogate end point in studies of IgA nephropathy: An individual-patient meta-analysis. Am J Kidney Dis 68: 392401, 2016 10.1053/j.ajkd.2016.02.042 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 96.

    Heerspink HJL, Stefánsson BV, Correa-Rotter R, Chertow GM, Greene T, Hou F-F, et al.; DAPA-CKD Trial Committees and Investigators: Dapagliflozin in patients with chronic kidney disease. N Engl J Med 383: 14361446, 2020 10.1056/NEJMoa2024816 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 97.

    Herrington WG, Staplin N, Wanner C, Green JB, Hauske SJ, Emberson JR, et al.; The EMPA-KIDNEY Collaborative Group: Empagliflozin in patients with chronic kidney disease. N Engl J Med 388: 117127, 2023 10.1056/NEJMoa2204233 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 98.

    Wheeler DC, Toto RD, Stefánsson BV, Jongs N, Chertow GM, Greene T, et al. DAPA-CKD Trial Committees and Investigators: A pre-specified analysis of the DAPA-CKD trial demonstrates the effects of dapagliflozin on major adverse kidney events in patients with IgA nephropathy. Kidney Int 100: 215224, 2021 10.1016/j.kint.2021.03.033 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 99.

    Nuffield Department of Population Health Renal Studies Group; SGLT2 Inhibitor Meta-Analysis Cardio-Renal Trialists’ Consortium: Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: Collaborative meta-analysis of large placebo-controlled trials. Lancet 400: 17881801, 2022 10.1016/S0140-6736(22)02074-8 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 100.

    Kohan DE, Barratt J, Heerspink HJL, Campbell KN, Camargo M, Ogbaa I, et al.: Targeting the endothelin A receptor in IgA nephropathy. Kidney Int Rep 8: 21982210, 2023 10.1016/j.ekir.2023.07.023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 101.

    Rovin BH, Barratt J, Heerspink HJL, Alpers CE, Bieler S, Chae D-W, et al.; DUPRO steering committee and PROTECT Investigators: Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial. Lancet 402: 20772090, 2023 10.1016/S0140-6736(23)02302-4 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 102.

    Heerspink HJL, Jardine M, Kohan DE, Lafayette RA, Levin A, Liew A, et al.; ALIGN Study Investigators: Atrasentan in patients with IgA nephropathy. N Engl J Med 392: 544554, 2024 10.1056/NEJMoa2409415 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 103.

    Lv J, Zhang H, Wong MG, Jardine MJ, Hladunewich M, Jha V, et al.; TESTING Study Group: Effect of oral methylprednisolone on clinical outcomes in patients with IgA nephropathy: The TESTING randomized clinical trial. JAMA 318: 432442, 2017 10.1001/jama.2017.9362 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 104.

    Lv J, Wong MG, Hladunewich MA, Jha V, Hooi LS, Monaghan H, et al.; TESTING Study Group: Effect of oral methylprednisolone on decline in kidney function or kidney failure in patients with IgA nephropathy: The TESTING randomized clinical trial. JAMA 327: 18881898, 2022 10.1001/jama.2022.5368 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 105.

    Kim D, Lv J, Hladunewich M, Jha V, Hooi LS, Monaghan H, et al.; TESTING trial steering committee: The efficacy and safety of reduced-dose oral methylprednisolone in high-risk immunoglobulin A nephropathy. Kidney Int Rep 9: 21682179, 2024 10.1016/j.ekir.2024.03.032 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 106.

    Tang S, Leung JCK, Chan LYY, Lui YH, Tang CSO, Kan CH, et al.: Mycophenolate mofetil alleviates persistent proteinuria in IgA nephropathy. Kidney Int 68: 802812, 2005 10.1111/j.1523-1755.2005.00460.x PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 107.

    Tang SC, Tang AW, Wong SS, Leung JC, Ho YW, Lai KN: Long-term study of mycophenolate mofetil treatment in IgA nephropathy. Kidney Int 77: 543549, 2010 10.1038/ki.2009.499 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 108.

    Hou FF, Xie D, Wang J, Xu X, Yang X, Ai J, et al.; MAIN Trial Investigators: Effectiveness of mycophenolate mofetil among patients with progressive IgA nephropathy: A randomized clinical trial. JAMA Netw Open 6: e2254054, 2023 10.1001/jamanetworkopen.2022.54054 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 109.

    Hou J-H, Le W-B, Chen N, Wang W-M, Liu Z-S, Liu D, et al.: Mycophenolate mofetil combined with prednisone versus full-dose prednisone in IgA nephropathy with active proliferative lesions: A randomized controlled trial. Am J Kidney Dis 69: 788795, 2017 10.1053/j.ajkd.2016.11.027 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 110.

    Stefan G, Mircescu G: Hydroxychloroquine in IgA nephropathy: A systematic review. Ren Fail 43: 15201527, 2021 10.1080/0886022X.2021.2000875 PubMed

  • 111.

    Liu L-J, Yang Y-Z, Shi S-F, Bao Y-F, Yang C, Zhu S-N, et al.: Effects of hydroxychloroquine on proteinuria in IgA nephropathy: A randomized controlled trial. Am J Kidney Dis 74: 1522, 2019 10.1053/j.ajkd.2019.01.026 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 112.

    Barratt J, Lafayette R, Kristensen J, Stone A, Cattran D, Floege J, et al.; NefIgArd Trial Investigators: Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy. Kidney Int 103: 391402, 2022 10.1016/j.kint.2022.09.017 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 113.

    Lafayette R, Kristensen J, Stone A, Floege J, Tesař V, Trimarchi H, et al.; NefIgArd trial investigators: Efficacy and safety of a targeted-release formulation of budesonide in patients with primary IgA nephropathy (NefIgArd): 2-year results from a randomised phase 3 trial. Lancet 402: 859870, 2023 10.1016/S0140-6736(23)01554-4 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 114.

    Lafayette R, Tumlin J, Fenoglio R, Kaufeld J, Pérez Valdivia , Wu M-S, et al.; SANCTUARY Study Investigators: Efficacy and safety of ravulizumab in IgA nephropathy: A phase 2 randomized double-blind placebo-controlled trial [published online ahead of print Oct 25, 2024]. J Am Soc Nephrol, doi:10.1681/ASN.0000000534 2024 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 115.

    Barratt J, Barbour SJ, Brenner RM, Cooper K, Wei X, Eren N, et al.; ORIGIN Phase 2b Investigators: Long-term results from an open-label extension study of atacicept for the treatment of IgA nephropathy. J Am Soc Nephrol, 2024 10.1681/ASN.0000000541 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 116.

    Mathur M, Barratt J, Chacko B, Chan TM, Kooienga L, Oh K-H, et al.; ENVISION Trial Investigators Group: A phase 2 trial of sibeprenlimab in patients with IgA nephropathy. N Engl J Med 390: 2031, 2024 10.1056/NEJMoa2305635 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 117.

    Zhang H, Rizk DV, Perkovic V, Maes B, Kashihara N, Rovin B, et al.: Results of a randomized double-blind placebo-controlled phase 2 study propose iptacopan as an alternative complement pathway inhibitor for IgA nephropathy. Kidney Int 105: 189199, 2024 10.1016/j.kint.2023.09.027 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 118.

    Perkovic V, Barratt J, Rovin B, Kashihara N, Maes B, Zhang H, et al.; APPLAUSE-IgAN Investigators: Alternative complement pathway inhibition with iptacopan in IgA nephropathy. N Engl J Med 392: 531543, 2024 10.1056/NEJMoa2410316 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 119.

    Barratt J, Liew A, Yeo SC, Fernström A, Barbour SJ, Sperati CJ, et al.; Cemdisiran Phase 2 Study Investigators and Collaborators: Phase 2 trial of cemdisirancin adult patients with IgA nephropathy: A randomized controlled trial. Clin J Am Soc Nephrol 19: 452462, 2024 10.2215/CJN.0000000000000384 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 120.

    Lee JW, Sicre de Fontbrune F, Wong Lee Lee L, Pessoa V, Gualandro S, Füreder W, et al.: Ravulizumab (ALXN1210) vs eculizumab in adult patients with PNH naive to complement inhibitors: The 301 study. Blood 133: 530539, 2019 10.1182/blood-2018-09-876136 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 121.

    Lafayette R, Barbour S, Israni R, Wei X, Eren N, Floege J, et al.: A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy. Kidney Int 105: 13061315, 2024 10.1016/j.kint.2024.03.012 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 122.

    Arivazhagan S, Lamech TM, Myvizhiselvi M, Arumugam V, Alavudeen SS, Dakshinamoorthy S, et al.: Efficacy of corticosteroids in infection-related glomerulonephritis–A randomized controlled trial. Kidney Int Rep 7: 21602165, 2022 10.1016/j.ekir.2022.07.163 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation

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