StanescuHC, Arcos-BurgosM, MedlarA, BockenhauerD, KottgenA, DragomirescuL, et al.: Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. N Engl J Med 364: 616–626, 2011PubMed)| false
KirylukK, Sanchez-RodriguezE, ZhouXJ, ZanoniF, LiuL, MladkovaN, et al.: Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy. Nat Genet55: 1091–1105, 2023PubMed
KirylukK, Sanchez-RodriguezE, ZhouXJ, ZanoniF, LiuL, MladkovaN, et al.: Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy. Nat Genet 55: 1091–1105, 2023PubMed)| false
XuX, WangG, ChenN, LuT, NieS, XuG, et al.: Long-term exposure to air pollution and increased risk of membranous nephropathy in China. J Am Soc Nephrol27: 3739–3746, 2016PubMed
XuX, WangG, ChenN, LuT, NieS, XuG, et al.: Long-term exposure to air pollution and increased risk of membranous nephropathy in China. J Am Soc Nephrol 27: 3739–3746, 2016PubMed)| false
ThompsonA, CarrollK, InkerLA, FloegeJ, PerkovicV, Boyer-SuavetS, et al.: Proteinuria reduction as a surrogate end point in trials of IgA nephropathy. Clin J Am Soc Nephrol14: 469–481, 2019PubMed
ThompsonA, CarrollK, InkerLA, FloegeJ, PerkovicV, Boyer-SuavetS, et al.: Proteinuria reduction as a surrogate end point in trials of IgA nephropathy. Clin J Am Soc Nephrol 14: 469–481, 2019PubMed)| false
InkerLA, HeerspinkHJL, TighiouartH, ChaudhariJ, MiaoS, DivaU, et al.: Association of treatment effects on early change in urine protein and treatment effects on GFR slope in IgA nephropathy: An individual participant meta-analysis. Am J Kidney Dis78: 340–349.e1, 2021PubMed
InkerLA, HeerspinkHJL, TighiouartH, ChaudhariJ, MiaoS, DivaU, et al.: Association of treatment effects on early change in urine protein and treatment effects on GFR slope in IgA nephropathy: An individual participant meta-analysis. Am J Kidney Dis 78: 340–349.e1, 2021PubMed)| false
ReichHN, TroyanovS, ScholeyJW, CattranDC, Toronto Glomerulonephritis Registry: Remission of proteinuria improves prognosis in IgA nephropathy. J Am Soc Nephrol18: 3177–3183, 2007PubMed
ReichHN, TroyanovS, ScholeyJW, CattranDC, Toronto Glomerulonephritis Registry: Remission of proteinuria improves prognosis in IgA nephropathy. J Am Soc Nephrol 18: 3177–3183, 2007PubMed)| false
RovinBH, BarrattJ, HeerspinkHJL, AlpersCE, BielerS, ChaeDW, et al.; DUPRO steering committee and PROTECT Investigators: Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial. Lancet402: 2077–2090, 2023PubMed
RovinBH, BarrattJ, HeerspinkHJL, AlpersCE, BielerS, ChaeDW, et al.; DUPRO steering committee and PROTECT Investigators: Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial. Lancet 402: 2077–2090, 2023PubMed)| false
LafayetteR, KristensenJ, StoneA, FloegeJ, TesařV, TrimarchiH, et al.; NefIgArd trial investigators: Efficacy and safety of a targeted-release formulation of budesonide in patients with primary IgA nephropathy (NefIgArd): 2-year results from a randomised phase 3 trial. Lancet402: 859–870, 2023PubMed
LafayetteR, KristensenJ, StoneA, FloegeJ, TesařV, TrimarchiH, et al.; NefIgArd trial investigators: Efficacy and safety of a targeted-release formulation of budesonide in patients with primary IgA nephropathy (NefIgArd): 2-year results from a randomised phase 3 trial. Lancet 402: 859–870, 2023PubMed)| false
PerkovicV, BarrattJ, RovinB, KashiharaN, MaesB, ZhangH, et al.: Alternative complement pathway inhibition with iptacopan in IgA nephropathy [published online ahead of print Oct 25, 2024]. N Engl J Med, doi:10.1056/NEJMoa24103162024PubMed
PerkovicV, BarrattJ, RovinB, KashiharaN, MaesB, ZhangH, et al.: Alternative complement pathway inhibition with iptacopan in IgA nephropathy [published online ahead of print Oct 25, 2024]. N Engl J Med, doi:10.1056/NEJMoa24103162024PubMed)| false
MathurM, BarrattJ, ChackoB, ChanTM, KooiengaL, OhKH, et al.; ENVISION Trial Investigators Group: A phase 2 trial of sibeprenlimab in patients with IgA nephropathy. N Engl J Med390: 20–31, 2024PubMed
MathurM, BarrattJ, ChackoB, ChanTM, KooiengaL, OhKH, et al.; ENVISION Trial Investigators Group: A phase 2 trial of sibeprenlimab in patients with IgA nephropathy. N Engl J Med 390: 20–31, 2024PubMed)| false
ThompsonA, CattranDC, BlankM, NachmanPH: Complete and partial remission as surrogate end points in membranous nephropathy. J Am Soc Nephrol26: 2930–2937, 2015PubMed
ThompsonA, CattranDC, BlankM, NachmanPH: Complete and partial remission as surrogate end points in membranous nephropathy. J Am Soc Nephrol 26: 2930–2937, 2015PubMed)| false
PolancoN, GutierrezE, CovarsiA, ArizaF, CarrenoA, VigilA, et al.; Grupo de Estudio de las Enfermedades Glomerulares de la Sociedad Española de Nefrología: Spontaneous remission of nephrotic syndrome in idiopathic membranous nephropathy. J Am Soc Nephrol21: 697–704, 2010PubMed
PolancoN, GutierrezE, CovarsiA, ArizaF, CarrenoA, VigilA, et al.; Grupo de Estudio de las Enfermedades Glomerulares de la Sociedad Española de Nefrología: Spontaneous remission of nephrotic syndrome in idiopathic membranous nephropathy. J Am Soc Nephrol 21: 697–704, 2010PubMed)| false
GaoS, CuiZ, ZhaoMH: Complement C3a and C3a receptor activation mediates podocyte injuries in the mechanism of primary membranous nephropathy. J Am Soc Nephrol33: 1742–1756, 2022PubMed
LernerGB, VirmaniS, HendersonJM, FrancisJM, BeckLHJr.: A conceptual framework linking immunology, pathology, and clinical features in primary membranous nephropathy. Kidney Int 100: 289–300, 2021PubMed)| false
LvJ, WongMG, HladunewichMA, JhaV, HooiLS, MonaghanH, et al.; TESTING Study Group: Effect of oral methylprednisolone on decline in kidney function or kidney failure in patients with IgA nephropathy: The TESTING randomized clinical trial. JAMA327: 1888–1898, 2022PubMed
LvJ, WongMG, HladunewichMA, JhaV, HooiLS, MonaghanH, et al.; TESTING Study Group: Effect of oral methylprednisolone on decline in kidney function or kidney failure in patients with IgA nephropathy: The TESTING randomized clinical trial. JAMA 327: 1888–1898, 2022PubMed)| false
DahanK, DebiecH, PlaisierE, CachanadoM, RousseauA, WakselmanL, et al.; GEMRITUX Study Group: Rituximab for severe membranous nephropathy: A 6-month trial with extended follow-up. J Am Soc Nephrol28: 348–358, 2017PubMed
DahanK, DebiecH, PlaisierE, CachanadoM, RousseauA, WakselmanL, et al.; GEMRITUX Study Group: Rituximab for severe membranous nephropathy: A 6-month trial with extended follow-up. J Am Soc Nephrol 28: 348–358, 2017PubMed)| false
FervenzaFC, AppelGB, BarbourSJ, RovinBH, LafayetteRA, AslamN, et al.; MENTOR Investigators: Rituximab or cyclosporine in the treatment of membranous nephropathy. N Engl J Med381: 36–46, 2019PubMed
FervenzaFC, AppelGB, BarbourSJ, RovinBH, LafayetteRA, AslamN, et al.; MENTOR Investigators: Rituximab or cyclosporine in the treatment of membranous nephropathy. N Engl J Med 381: 36–46, 2019PubMed)| false
Fernandez-JuarezG, Rojas-RiveraJ, LogtAV, JustinoJ, SevillanoA, Caravaca-FontanF, et al.; STARMEN Investigators: The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy. Kidney Int99: 986–998, 2021PubMed
Fernandez-JuarezG, Rojas-RiveraJ, LogtAV, JustinoJ, SevillanoA, Caravaca-FontanF, et al.; STARMEN Investigators: The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy. Kidney Int 99: 986–998, 2021PubMed)| false
PonticelliC, AltieriP, ScolariF, PasseriniP, RoccatelloD, CesanaB, et al.: A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. J Am Soc Nephrol9: 444–450, 1998PubMed
PonticelliC, AltieriP, ScolariF, PasseriniP, RoccatelloD, CesanaB, et al.: A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. J Am Soc Nephrol 9: 444–450, 1998PubMed)| false
JhaV, GanguliA, SahaTK, KohliHS, SudK, GuptaKL, et al.: A randomized, controlled trial of steroids and cyclophosphamide in adults with nephrotic syndrome caused by idiopathic membranous nephropathy. J Am Soc Nephrol18: 1899–1904, 2007PubMed
JhaV, GanguliA, SahaTK, KohliHS, SudK, GuptaKL, et al.: A randomized, controlled trial of steroids and cyclophosphamide in adults with nephrotic syndrome caused by idiopathic membranous nephropathy. J Am Soc Nephrol 18: 1899–1904, 2007PubMed)| false
ScolariF, DelbarbaE, SantoroD, GesualdoL, PaniA, DalleraN, et al.; RI-CYCLO Investigators: Rituximab or cyclophosphamide in the treatment of membranous nephropathy: The RI-CYCLO randomized trial. J Am Soc Nephrol32: 972–982, 2021PubMed
ScolariF, DelbarbaE, SantoroD, GesualdoL, PaniA, DalleraN, et al.; RI-CYCLO Investigators: Rituximab or cyclophosphamide in the treatment of membranous nephropathy: The RI-CYCLO randomized trial. J Am Soc Nephrol 32: 972–982, 2021PubMed)| false
De VrieseAS, GlassockRJ, NathKA, SethiS, FervenzaFC: A proposal for a serology-based approach to membranous nephropathy. J Am Soc Nephrol28: 421–430, 2017PubMed
De VrieseAS, GlassockRJ, NathKA, SethiS, FervenzaFC: A proposal for a serology-based approach to membranous nephropathy. J Am Soc Nephrol 28: 421–430, 2017PubMed)| false
RovinBH, AdlerSG, BarrattJ, BridouxF, BurdgeKA, ChanTM, et al.; Kidney Disease: Improving Global Outcomes (KDIGO) Workgroup: 2021 clinical practice guideline for the management of glomerular diseases. Kidney Int100: S1–S276, 2021PubMed
RovinBH, AdlerSG, BarrattJ, BridouxF, BurdgeKA, ChanTM, et al.; Kidney Disease: Improving Global Outcomes (KDIGO) Workgroup: 2021 clinical practice guideline for the management of glomerular diseases. Kidney Int 100: S1–S276, 2021PubMed)| false
TomasNM, SchnarreA, DehdeS, LucasR, Hermans-BorgmeyerI, KretzO, et al.: Introduction of a novel chimeric active immunization mouse model of PLA2R1-associated membranous nephropathy. Kidney Int104: 916–928, 2023PubMed
TomasNM, SchnarreA, DehdeS, LucasR, Hermans-BorgmeyerI, KretzO, et al.: Introduction of a novel chimeric active immunization mouse model of PLA2R1-associated membranous nephropathy. Kidney Int 104: 916–928, 2023PubMed)| false
DuY, LiJ, HeF, LvY, LiuW, WuP, et al.: The diagnosis accuracy of PLA2R-AB in the diagnosis of idiopathic membranous nephropathy: A meta-analysis. PLoS One9: e104936, 2014PubMed
DuY, LiJ, HeF, LvY, LiuW, WuP, et al.: The diagnosis accuracy of PLA2R-AB in the diagnosis of idiopathic membranous nephropathy: A meta-analysis. PLoS One 9: e104936, 2014PubMed)| false
VinkCH, LogtAV, van der MolenRG, HofstraJM, WetzelsJFM: Antibody-guided therapy in phospholipase A2 receptor-associated membranous nephropathy. Kidney Int Rep8: 432–441, 2023PubMed
TampoiaM, MigliucciF, VillaniC, AbbracciaventoL, RossiniM, FumaruloR, et al.: Definition of a new cut-off for the anti-phospholipase A2 receptor (PLA2R) autoantibody immunoassay in patients affected by idiopathic membranous nephropathy. J Nephrol31: 899–905, 2018PubMed
TampoiaM, MigliucciF, VillaniC, AbbracciaventoL, RossiniM, FumaruloR, et al.: Definition of a new cut-off for the anti-phospholipase A2 receptor (PLA2R) autoantibody immunoassay in patients affected by idiopathic membranous nephropathy. J Nephrol 31: 899–905, 2018PubMed)| false
LiuY, LiX, MaC, WangP, LiuJ, SuH, et al.: Serum anti-PLA2R antibody as a diagnostic biomarker of idiopathic membranous nephropathy: The optimal cut-off value for Chinese patients. Clin Chim Acta476: 9–14, 2018PubMed
LiuY, LiX, MaC, WangP, LiuJ, SuH, et al.: Serum anti-PLA2R antibody as a diagnostic biomarker of idiopathic membranous nephropathy: The optimal cut-off value for Chinese patients. Clin Chim Acta 476: 9–14, 2018PubMed)| false
PrunottoM, NachmanPH, GillespieB, BeckLHJr., ThompsonAM, et al.: Designing clinical trials for the treatment of membranous nephropathy in the anti-PLA2R era: Results of a Nephcure Membranous Nephropathy Workshop. Kidney Int2025, in press
PrunottoM, NachmanPH, GillespieB, BeckLHJr., ThompsonAM, et al.: Designing clinical trials for the treatment of membranous nephropathy in the anti-PLA2R era: Results of a Nephcure Membranous Nephropathy Workshop. Kidney Int 2025, in press)| false
SuX, WuB, TieX, GuoX, FengR, QiaoX, et al.: Obinutuzumab as initial or second-line therapy in patients with primary membranous nephropathy. Kidney Int Rep9: 2386–2398, 2024PubMed
SuX, WuB, TieX, GuoX, FengR, QiaoX, et al.: Obinutuzumab as initial or second-line therapy in patients with primary membranous nephropathy. Kidney Int Rep 9: 2386–2398, 2024PubMed)| false
HuX, ZhangM, XuJ, GaoC, YuX, LiX, et al.: Comparison of obinutuzumab and rituximab for treating primary membranous nephropathy. Clin J Am Soc Nephrol19: 1594–1602, 2024PubMed
RovinBH, RoncoPM, WetzelsJFM, AdlerSG, AyoubI, ZaouiP, et al.: Phase 1b/2a study assessing the safety and efficacy of felzartamab in anti-phospholipase A2 receptor autoantibody-positive primary membranous nephropathy. Kidney Int Rep9: 2635–2647, 2024PubMed
RovinBH, RoncoPM, WetzelsJFM, AdlerSG, AyoubI, ZaouiP, et al.: Phase 1b/2a study assessing the safety and efficacy of felzartamab in anti-phospholipase A2 receptor autoantibody-positive primary membranous nephropathy. Kidney Int Rep 9: 2635–2647, 2024PubMed)| false
ReinhardL, MachalitzaM, WiechT, GroneHJ, LasseM, RinschenMM, et al.: Netrin G1 is a novel target antigen in primary membranous nephropathy. J Am Soc Nephrol33: 1823–1831, 2022PubMed