Pharmacotherapeutic Strategies to Prevent Progression to ESKD and Reduce Cardiovascular Risk
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Ayodele Odutayo University Health Network, Toronto General Hospital Research Institute and Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada

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David Cherney University Health Network, Toronto General Hospital Research Institute, University of Toronto, Toronto, Canada

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  • 1.

    GBD Chronic Kidney Disease Collaboration: Global, regional, and national burden of chronic kidney disease, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet 395: 709733, 2020 10.1016/S0140-6736(20)30045-3 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Cherney DZI, Perkins BA, Soleymanlou N, Maione M, Lai V, Lee A, et al.: Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus. Circulation 129: 587597, 2014 10.1161/CIRCULATIONAHA.113.005081 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Wada Y, Kidokoro K, Kondo M, Tokuyama A, Kadoya H, Nagasu H, et al.: Evaluation of glomerular hemodynamic changes by sodium-glucose-transporter 2 inhibition in type 2 diabetic rats using in vivo imaging. Kidney Int 106: 408418, 2024 10.1016/j.kint.2024.05.006 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Yau K, Cherney DZI, van Raalte DH, Wever BE: Kidney protective mechanisms of SGLT2 inhibitors: Evidence for a hemodynamic effect. Kidney Int 105: 11681172, 2024 10.1016/j.kint.2024.03.019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    van Bommel EJM, Lytvyn Y, Perkins BA, Soleymanlou N, Fagan NM, Koitka-Weber A, et al.: Renal hemodynamic effects of sodium-glucose cotransporter 2 inhibitors in hyperfiltering people with type 1 diabetes and people with type 2 diabetes and normal kidney function. Kidney Int 97: 631635, 2020 10.1016/j.kint.2019.12.021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Cherney DZI, Cosentino F, Dagogo-Jack S, McGuire DK, Pratley RE, Frederich R, VERTIS CV Investigators, et al.: Initial eGFR changes with ertugliflozin and associations with clinical parameters: Analyses from the VERTIS CV trial. Am J Nephrol 53: 516525, 2022 10.1159/000524889 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Heerspink HJL, Cherney DZI: Clinical implications of an acute dip in eGFR after SGLT2 inhibitor initiation. Clin J Am Soc Nephrol 16: 12781280, 2021 10.2215/CJN.02480221 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Kraus BJ, Weir MR, Bakris GL, Mattheus M, Cherney DZI, Sattar N, et al.: Characterization and implications of the initial estimated glomerular filtration rate “dip” upon sodium-glucose cotransporter-2 inhibition with empagliflozin in the EMPA-REG OUTCOME trial. Kidney Int 99: 750762, 2021 10.1016/j.kint.2020.10.031 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Mayne KJ, Staplin N, Keane DF, Wanner C, Brenner S, Cejka V, EMPA-KIDNEY Collaborative Group, et al.: Effects of empagliflozin on fluid overload, weight, and blood pressure in CKD. J Am Soc Nephrol 35: 202215, 2024 10.1681/ASN.0000000000000271 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Sen T, Scholtes R, Greasley PJ, Cherney DZI, Dekkers CCJ, Vervloet M, et al.: Effects of dapagliflozin on volume status and systemic haemodynamics in patients with chronic kidney disease without diabetes: Results from DAPASALT and DIAMOND. Diabetes Obes Metab 24: 15781587, 2022 10.1111/dom.14729 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Cherney DZ, Kanbay M, Lovshin JA: Renal physiology of glucose handling and therapeutic implications. Nephrol Dial Transplant 35[Suppl 1]: i3i12, 2020 10.1093/ndt/gfz230 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Cherney DZI, Dekkers CCJ, Barbour SJ, Cattran D, Abdul Gafor AH, Greasley PJ, DIAMOND investigators, et al.: Effects of the SGLT2 inhibitor dapagliflozin on proteinuria in non-diabetic patients with chronic kidney disease (DIAMOND): A randomised, double-blind, crossover trial. Lancet Diabetes Endocrinol 8: 582593, 2020 10.1016/S2213-8587(20)30162-5 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Perkovic V, Jardine MJ, Neal B, Bompoint S, Heerspink HJL, Charytan DM, CREDENCE Trial Investigators, et al.: Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. N Engl J Med 380: 22952306, 2019 10.1056/NEJMoa1811744 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Heerspink HJL, Stefánsson BV, Correa-Rotter R, Chertow GM, Greene T, Hou F-F, DAPA-CKD Trial Committees and Investigators, et al.: Dapagliflozin in patients with chronic kidney disease. N Engl J Med 383: 14361446, 2020 10.1056/NEJMoa2024816 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Herrington WG, Staplin N, Wanner C, Green JB, Hauske SJ, Emberson JR, The EMPA-KIDNEY Collaborative Group, et al.: Empagliflozin in patients with chronic kidney disease. N Engl J Med 388: 117127, 2023 10.1056/NEJMoa2204233 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Bhatt DL, Szarek M, Pitt B, Cannon CP, Leiter LA, McGuire DK, SCORED Investigators, et al.: Sotagliflozin in patients with diabetes and chronic kidney disease. N Engl J Med 384: 129139, 2021 10.1056/NEJMoa2030186 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Sridhar VS, Bhatt DL, Odutayo A, Szarek M, Davies MJ, Banks P, et al.: Sotagliflozin and kidney outcomes, kidney function, and albuminuria in type 2 diabetes and CKD: A secondary analysis of the SCORED trial. Clin J Am Soc Nephrol 19: 557564, 2024 10.2215/CJN.0000000000000414 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Nuffield Department of Population Health Renal Studies Group: SGLT2 inhibitor meta-analysis cardio-renal trialists’ consortium. Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: Collaborative meta-analysis of large placebo-controlled trials. Lancet 400: 17881801, 2022 10.1016/S0140-6736(22)02074-8 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Heerspink HJL, Cherney D, Postmus D, Stefánsson BV, Chertow GM, Dwyer JP, DAPA-CKD Trial Committees and Investigators, et al.: A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function. Kidney Int 101: 174184, 2022 10.1016/j.kint.2021.09.005 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Neuen BL, Oshima M, Agarwal R, Arnott C, Cherney DZ, Edwards R, et al.: Sodium-glucose cotransporter 2 inhibitors and risk of hyperkalemia in people with type 2 diabetes: A meta-analysis of individual participant data from randomized, controlled trials. Circulation 145: 14601470, 2022 10.1161/CIRCULATIONAHA.121.057736 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21.

    Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group: KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int 105: S117S314, 2024 10.1016/j.kint.2023.10.018 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22.

    Baggio LL, Drucker DJ: Biology of incretins: GLP-1 and GIP. Gastroenterology 132: 21312157, 2007 10.1053/j.gastro.2007.03.054 PubMed

  • 23.

    Cherney DZI, Udell JA, Drucker DJ: Cardiorenal mechanisms of action of glucagon-like-peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors. Med 2: 12031230, 2021 10.1016/j.medj.2021.10.004 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24.

    Yau K, Odutayo A, Dash S, Cherney DZI: Biology and clinical use of glucagon-like peptide-1 receptor agonists in vascular protection. Can J Cardiol 39: 18161838, 2023 10.1016/j.cjca.2023.07.007 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25.

    Cherney DZI, Hadjadj S, Lawson J, Mosenzon O, Tuttle K, Vrhnjak B, et al.: Hemoglobin A1c reduction with the GLP-1 receptor agonist semaglutide is independent of baseline eGFR: Post hoc analysis of the SUSTAIN and PIONEER programs. Kidney Int Rep 7: 23452355, 2022 10.1016/j.ekir.2022.07.167 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Cherney DZ, Tuttle KR: Liraglutide for the treatment of type 2 diabetes and safety in diabetic kidney disease: Liraglutide and diabetic kidney disease. Clin J Am Soc Nephrol 15: 444446, 2020 10.2215/CJN.01260120 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27.

    Tuttle KR, Bosch-Traberg H, Cherney DZI, Hadjadj S, Lawson J, Mosenzon O, et al.: Post hoc analysis of SUSTAIN 6 and PIONEER 6 trials suggests that people with type 2 diabetes at high cardiovascular risk treated with semaglutide experience more stable kidney function compared with placebo. Kidney Int 103: 772781, 2023 10.1016/j.kint.2022.12.028 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28.

    Shaman AM, Bain SC, Bakris GL, Buse JB, Idorn T, Mahaffey KW, et al.: Effect of the glucagon-like peptide-1 receptor agonists semaglutide and liraglutide on kidney outcomes in patients with type 2 diabetes: Pooled analysis of SUSTAIN 6 and LEADER. Circulation 145: 575585, 2022 10.1161/CIRCULATIONAHA.121.055459 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 29.

    Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, REWIND Investigators, et al.: Dulaglutide and renal outcomes in type 2 diabetes: An exploratory analysis of the REWIND randomised, placebo-controlled trial. Lancet 394: 131138, 2019 10.1016/S0140-6736(19)31150-X PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 30.

    Perkovic V, Tuttle KR, Rossing P, Mahaffey KW, Mann JFE, Bakris G, FLOW Trial Committees and Investigators, et al.: Effects of semaglutide on chronic kidney disease in patients with type 2 diabetes. N Engl J Med 391: 109121, 2024 10.1056/NEJMoa2403347 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31.

    Colhoun HM, Lingvay I, Brown PM, Deanfield J, Brown-Frandsen K, Kahn SE, et al.: Long-term kidney outcomes of semaglutide in obesity and cardiovascular disease in the SELECT trial. Nat Med 30: 20582066, 2024 10.1038/s41591-024-03015-5 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 32.

    Heerspink HJL, Sattar N, Pavo I, Haupt A, Duffin KL, Yang Z, et al.: Effects of tirzepatide versus insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 trial: Post-hoc analysis of an open-label, randomised, phase 3 trial. Lancet Diabetes Endocrinol 10: 774785, 2022 10.1016/S2213-8587(22)00243-1 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 33.

    Agarwal R, Kolkhof P, Bakris G, Bauersachs J, Haller H, Wada T, et al.: Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine. Eur Heart J 42: 152161, 2021 10.1093/eurheartj/ehaa736 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 34.

    Albakr RB, Sridhar VS, Cherney DZI: Novel therapies in diabetic kidney disease and risk of hyperkalemia: A review of the evidence from clinical trials. Am J Kidney Dis 82: 737742, 2023 10.1053/j.ajkd.2023.04.015 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35.

    Bakris GL, Agarwal R, Anker SD, Pitt B, Ruilope LM, Rossing P, FIDELIO-DKD Investigators, et al.: Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes. N Engl J Med 383: 22192229, 2020 10.1056/NEJMoa2025845 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 36.

    Pitt B, Filippatos G, Agarwal R, Anker SD, Bakris GL, Rossing P, FIGARO-DKD Investigators, et al.: Cardiovascular events with finerenone in kidney disease and type 2 diabetes. N Engl J Med 385: 22522263, 2021 10.1056/NEJMoa2110956 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 37.

    Bakris GL, Ruilope LM, Anker SD, Filippatos G, Pitt B, Rossing P, FIDELIO-DKD and FIGARO-DKD Investigators, et al.: A prespecified exploratory analysis from FIDELITY examined finerenone use and kidney outcomes in patients with chronic kidney disease and type 2 diabetes. Kidney Int 103: 196206, 2023 10.1016/j.kint.2022.08.040 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 38.

    Oberprieler NG, Kovesdy CP, Layton JB, Thapa B, Curhan G, Farjat AE, et al.: Clinical outcomes in US patients initiating finerenone – A report from the FOUNTAIN platform. Nephrology Dialysis Transplantation 39[Suppl 1]: gfae069-14162022, 2024 10.1093/ndt/gfae069.1416

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 39.

    Heerspink HJL, Agarwal R, Bakris GL, Cherney DZI, Lam CSP, Neuen BL, FIND-CKD investigators, et al.: Design and baseline characteristics of the Finerenone, in addition to standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease (FIND-CKD) randomized trial [published online ahead of print Jun 11, 2024]. Nephrol Dial Transplant doi:10.1093/ndt/gfae132 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 40.

    Heerspink HJL, Birkenfeld AL, Cherney DZI, Colhoun HM, Ji L, Mathieu C, et al.: Rationale and design of a randomised phase III registration trial investigating finerenone in participants with type 1 diabetes and chronic kidney disease: The FINE-ONE trial. Diabetes Res Clin Pract 204: 110908, 2023 10.1016/j.diabres.2023.110908 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 41.

    Tuttle KR, Hauske SJ, Canziani ME, Caramori ML, Cherney D, Cronin L, ASi in CKD group, et al.: Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: A randomised, controlled, phase 2 trial. Lancet 403: 379390, 2024 10.1016/S0140-6736(23)02408-X PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 42.

    Kohan DE, Barton M: Endothelin and endothelin antagonists in chronic kidney disease. Kidney Int 86: 896904, 2014 10.1038/ki.2014.143 PubMed

  • 43.

    Mann JFE, Green D, Jamerson K, Ruilope LM, Kuranoff SJ, Littke T, ASCEND Study Group, et al.: Avosentan for overt diabetic nephropathy. J Am Soc Nephrol 21: 527535, 2010 10.1681/ASN.2009060593 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 44.

    Heerspink HJL, Parving H-H, Andress DL, Bakris G, Correa-Rotter R, Hou F-F, SONAR Committees and Investigators, et al.: Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): A double-blind, randomised, placebo-controlled trial. Lancet 393: 19371947, 2019 10.1016/S0140-6736(19)30772-X PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 45.

    Heerspink HJL, Kiyosue A, Wheeler DC, Lin M, Wijkmark E, Carlson G, et al.: Zibotentan in combination with dapagliflozin compared with dapagliflozin in patients with chronic kidney disease (ZENITH-CKD): A multicentre, randomised, active-controlled, phase 2b, clinical trial. Lancet 402: 20042017, 2023 10.1016/S0140-6736(23)02230-4 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 46.

    Rovin BH, Barratt J, Heerspink HJL, Alpers CE, Bieler S, Chae D-W, DUPRO steering committee and PROTECT Investigators, et al.: Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial. Lancet 402: 20772090, 2023 10.1016/S0140-6736(23)02302-4 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 47.

    Rheault MN, Alpers CE, Barratt J, Bieler S, Canetta P, Chae D-W, DUPRO Steering Committee and DUPLEX Investigators, et al.: Sparsentan versus irbesartan in focal segmental glomerulosclerosis. N Engl J Med 389: 24362445, 2023 10.1056/NEJMoa2308550 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 48.

    Thompson S, James M, Wiebe N, Hemmelgarn B, Manns B, Klarenbach S, Alberta Kidney Disease Network, et al.: Cause of death in patients with reduced kidney function. J Am Soc Nephrol 26: 25042511, 2015 10.1681/ASN.2014070714 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 49.

    Mark PB, Carrero JJ, Matsushita K, Sang Y, Ballew SH, Grams ME, et al.: Major cardiovascular events and subsequent risk of kidney failure with replacement therapy: A CKD Prognosis Consortium study. Eur Heart J 44: 11571166, 2023 10.1093/eurheartj/ehac825 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 50.

    Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S, EMPA-REG OUTCOME Investigators, et al.: Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 373: 21172128, 2015 10.1056/NEJMoa1504720 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 51.

    Neal B, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Erondu N, CANVAS Program Collaborative Group, et al.: Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med 377: 644657, 2017 10.1056/NEJMoa1611925 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 52.

    Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, DECLARE–TIMI 58 Investigators, et al.: Dapagliflozin and cardiovascular outcomes in type 2 diabetes. N Engl J Med 380: 347357, 2018 10.1056/NEJMoa1812389 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 53.

    Zelniker TA, Wiviott SD, Raz I, Im K, Goodrich EL, Bonaca MP, et al.: SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: A systematic review and meta-analysis of cardiovascular outcome trials. Lancet 393: 3139, 2018 10.1016/S0140-6736(18)32590-X PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 54.

    Patel SM, Kang YM, Im KAH, Neuen BL, Anker SD, Bhatt DL, et al.: Sodium-glucose cotransporter-2 inhibitors and major adverse cardiovascular outcomes: A SMART-C collaborative meta-analysis. Circulation 149: 17891801, 2024 10.1161/CIRCULATIONAHA.124.069568 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 55.

    Arnett DK, Blumenthal RS, Albert MA, Buroker A, Goldberger ZD, Hahn EJ, et al.: 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 140: e596e646, 2019 10.1161/CIR.0000000000000678 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 56.

    Virani SS, Newby LK, Arnold SV, Bittner V, Brewer LC, Demeter SH, Peer Review Committee Members, et al.: 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA guideline for the management of patients with chronic coronary disease: A report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation 148: e9e119, 2023 10.1161/CIR.0000000000001168 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 57.

    McMurray JJV, Solomon SD, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, DAPA-HF Trial Committees and Investigators, et al.: Dapagliflozin in patients with heart failure and reduced ejection fraction. N Engl J Med 381: 19952008, 2019 10.1056/NEJMoa1911303 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 58.

    Packer M, Anker SD, Butler J, Filippatos G, Pocock SJ, Carson P, EMPEROR-Reduced Trial Investigators, et al.: Cardiovascular and renal outcomes with empagliflozin in heart failure. N Engl J Med 383: 14131424, 2020 10.1056/NEJMoa2022190 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 59.

    Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Böhm M, EMPEROR-Preserved Trial Investigators, et al.: Empagliflozin in heart failure with a preserved ejection fraction. N Engl J Med 385: 14511461, 2021 10.1056/NEJMoa2107038 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 60.

    Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF, DELIVER Trial Committees and Investigators, et al.: Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction. N Engl J Med 387: 10891098, 2022 10.1056/NEJMoa2206286 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 61.

    Bhatt DL, Szarek M, Steg PG, Cannon CP, Leiter LA, McGuire DK, SOLOIST-WHF Trial Investigators, et al.: Sotagliflozin in patients with diabetes and recent worsening heart failure. N Engl J Med 384: 117128, 2021 10.1056/NEJMoa2030183 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 62.

    Berg DD, Jhund PS, Docherty KF, Murphy SA, Verma S, Inzucchi SE, et al.: Time to clinical benefit of dapagliflozin and significance of prior heart failure hospitalization in patients with heart failure with reduced ejection fraction. JAMA Cardiol 6: 499507, 2021 10.1001/jamacardio.2020.7585 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 63.

    Vaduganathan M, Claggett BL, Jhund P, de Boer RA, Hernandez AF, Inzucchi SE, et al.: Time to clinical benefit of dapagliflozin in patients with heart failure with mildly reduced or preserved ejection fraction: A prespecified secondary analysis of the DELIVER randomized clinical trial. JAMA Cardiol 7: 12591263, 2022 10.1001/jamacardio.2022.3750 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 64.

    Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al.: 2022 AHA/ACC/HFSA guideline for the management of heart failure: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 145: e895e1032, 2022 10.1161/CIR.0000000000001063 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 65.

    James S, Erlinge D, Storey RF, McGuire DK, de Belder M, Eriksson N, et al.: Dapagliflozin in myocardial infarction without diabetes or heart failure. NEJM Evid 3: EVIDoa2300286, 2023 10.1056/EVIDoa2300286 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 66.

    Butler J, Jones WS, Udell JA, Anker SD, Petrie MC, Harrington J, et al.: Empagliflozin after acute myocardial infarction. N Engl J Med 390: 14551466, 2024 10.1056/NEJMoa2314051 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 67.

    Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jódar E, Bain SC, et al.: Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med 375: 18341844, 2016 10.1056/NEJMoa1607141 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 68.

    Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, PIONEER 6 Investigators, et al.: Oral semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med 381: 841851, 2019 10.1056/NEJMoa1901118 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 69.

    McGuire DK, Busui RP, Deanfield J, Inzucchi SE, Mann JFE, Marx N, et al.: Effects of oral semaglutide on cardiovascular outcomes in individuals with type 2 diabetes and established atherosclerotic cardiovascular disease and/or chronic kidney disease: Design and baseline characteristics of SOUL, a randomized trial. Diabetes Obes Metab 25: 19321941, 2023 10.1111/dom.15058 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 70.

    Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, SELECT Trial Investigators, et al.: Semaglutide and cardiovascular outcomes in obesity without diabetes. N Engl J Med 389: 22212232, 2023 10.1056/NEJMoa2307563 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 71.

    Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JFE, Nauck MA, LEADER Trial Investigators, et al.: Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 375: 311322, 2016 10.1056/NEJMoa1603827 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 72.

    Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, REWIND Investigators, et al.: Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): A double-blind, randomised placebo-controlled trial. Lancet 394: 121130, 2019 10.1016/S0140-6736(19)31149-3 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 73.

    Agarwal R, Filippatos G, Pitt B, Anker SD, Rossing P, Joseph A, FIDELIO-DKD and FIGARO-DKD investigators, et al.: Cardiovascular and kidney outcomes with finerenone in patients with type 2 diabetes and chronic kidney disease: The FIDELITY pooled analysis. Eur Heart J 43: 474484, 2022 10.1093/eurheartj/ehab777 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 74.

    de Boer IH, Khunti K, Sadusky T, Tuttle KR, Neumiller JJ, Rhee CM, et al.: Diabetes management in chronic kidney disease: A consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO). Diabetes Care 45: 30753090, 2022 10.2337/dci22-0027 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 75.

    Baigent C, Landray MJ, Reith C, Emberson J, Wheeler DC, Tomson C, SHARP Investigators, et al.: The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): A randomised placebo-controlled trial. Lancet 377: 21812192, 2011 10.1016/S0140-6736(11)60739-3 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 76.

    Herrington W, Emberson J, Mihaylova B, Blackwell L, Reith C, Solbu M, Cholesterol Treatment Trialists’ (CTT) Collaboration, et al.: Impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: A meta-analysis of individual participant data from 28 randomised trials. Lancet Diabetes Endocrinol 4: 829839, 2016 10.1016/S2213-8587(16)30156-5 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 77.

    Wanner C, Tonelli M, the Kidney Disease: Improving Global Outcomes Lipid Guideline Development Work Group Members: KDIGO clinical practice guideline for lipid management in CKD: Summary of recommendation statements and clinical approach to the patient. Kidney Int 85: 13031309, 2014 10.1038/ki.2014.31 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 78.

    Neuen BL, Heerspink HJL, Vart P, Claggett BL, Fletcher RA, Arnott C, et al.: Estimated lifetime cardiovascular, kidney and mortality benefits of combination treatment with SGLT2 inhibitors, GLP-1 receptor agonists, and non-steroidal MRA compared with conventional care in patients with type 2 diabetes and albuminuria. Circulation 149: 450462, 2023 10.1161/CIRCULATIONAHA.123.067584 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation

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