Cardiorenal Syndrome
By:
Wendy McCallum Division of Nephrology, Tufts University School of Medicine, Boston, Massachusetts

Search for other papers by Wendy McCallum in
Current site
Google Scholar
PubMed
Close
and
Mark J. Sarnak Division of Nephrology, Tufts University School of Medicine, Boston, Massachusetts

Search for other papers by Mark J. Sarnak in
Current site
Google Scholar
PubMed
Close
  • Collapse
  • Expand
  • 1.

    Patel RB, Fonarow GC, Greene SJ, Zhang S, Alhanti B, DeVore AD, et al.: Kidney function and outcomes in patients hospitalized with heart failure. J Am Coll Cardiol 78: 330343, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Minhas AMK, Bhopalwala HM, Dewaswala N, Ijaz SH, Khan MS, Khan MZ, et al.: Association of chronic renal insufficiency with inhospital outcomes in primary heart failure hospitalizations (insights from the National Inpatient Sample 2004 to 2018). Am J Cardiol 202: 4149, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    McCallum W, Tighiouart H, Testani JM, Griffin M, Konstam MA, Udelson JE, et al.: Acute kidney function declines in the context of decongestion in acute decompensated heart failure. JACC Heart Fail 8: 537547, 2020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Metra M, Cotter G, Senger S, Edwards C, Cleland JG, Ponikowski P, et al.: Prognostic significance of creatinine increases during an acute heart failure admission in patients with and without residual congestion: A post hoc analysis of the PROTECT data. Circ Heart Fail 11: e004644, 2018 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Testani JM, Chen J, McCauley BD, Kimmel SE, Shannon RP: Potential effects of aggressive decongestion during the treatment of decompensated heart failure on renal function and survival. Circulation 122: 265272, 2010 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Emmens JE, Ter Maaten JM, Matsue Y, Figarska SM, Sama IE, Cotter G, et al.: Worsening renal function in acute heart failure in the context of diuretic response. Eur J Heart Fail 24: 365374, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Metra M, Teerlink JR, Cotter G, Davison BA, Felker GM, Filippatos G, et al.; RELAX-AHF-2 Committees Investigators: Effects of serelaxin in patients with acute heart failure. N Engl J Med 381: 716726, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Massie BM, O’Connor CM, Metra M, Ponikowski P, Teerlink JR, Cotter G, et al.; PROTECT Investigators and Committees: Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure. N Engl J Med 363: 14191428, 2010 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Colombo PC, Castagna F, Onat D, Wong KY, Harxhi A, Hayashi Y, et al.: Experimentally induced peripheral venous congestion exacerbates inflammation, oxidative stress, and neurohormonal and endothelial cell activation in patients with systolic heart failure. J Card Fail 30: 580591, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Eder M, Griffin M, Moreno-Villagomez J, Bellumkonda L, Maulion C, Asher J, et al.: The importance of forward flow and venous congestion in diuretic response in acute heart failure: Insights from the ESCAPE trial. Int J Cardiol 381: 5761, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Hanberg JS, Sury K, Wilson FP, Brisco MA, Ahmad T, Ter Maaten JM, et al.: Reduced cardiac index is not the dominant driver of renal dysfunction in heart failure. J Am Coll Cardiol 67: 21992208, 2016 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Nohria A, Hasselblad V, Stebbins A, Pauly DF, Fonarow GC, Shah M, et al.: Cardiorenal interactions: Insights from the ESCAPE trial. J Am Coll Cardiol 51: 12681274, 2008 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Mullens W, Abrahams Z, Francis GS, Sokos G, Taylor DO, Starling RC, et al.: Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J Am Coll Cardiol 53: 589596, 2009 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Damman K, Navis G, Smilde TDJ, Voors AA, van der Bij W, van Veldhuisen DJ, et al.: Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction. Eur J Heart Fail 9: 872878, 2007 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Lytvyn Y, Burns KD, Testani JM, Lytvyn A, Ambinathan JPN, Osuntokun O, et al.: Renal hemodynamics and renin-angiotensin-aldosterone system profiles in patients with heart failure. J Card Fail 28: 385393, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Boorsma EM, Ter Maaten JM, Damman K, van Veldhuisen DJ, Dickstein K, Anker SD, et al.: Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin-angiotensin-aldosterone system in patients with heart failure. Eur J Heart Fail 23: 947953, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Deniau B, Rehfeld L, Santos K, Dienelt A, Azibani F, Sadoune M, et al.: Circulating dipeptidyl peptidase 3 is a myocardial depressant factor: Dipeptidyl peptidase 3 inhibition rapidly and sustainably improves haemodynamics. Eur J Heart Fail 22: 290299, 2020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Miklovič M, Gawryś O, Honetschlägerová Z, Kala P, Husková Z, Kikerlová S, et al.: Renal denervation improves cardiac function independently of afterload and restores myocardial norepinephrine levels in a rodent heart failure model [published online ahead of print, Feb 2, 2024]. Hypertens Res doi:10.1038/s41440-024-01580-3, 2024 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Kresoja K-P, Rommel K-P, Fengler K, von Roeder M, Besler C, Lücke C, et al.: Renal sympathetic denervation in patients with heart failure with preserved ejection fraction. Circ Heart Fail 14: e007421, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Iwanek G, Ponikowska B, Zdanowicz A, Fudim M, Hurkacz M, Zymliński R, et al.: Relationship of vascular endothelial growth factor C, a lymphangiogenesis modulator, with edema formation, congestion and outcomes in acute heart failure. J Card Fail 29: 16291638, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21.

    Ahmad T, Jackson K, Rao VS, Tang WHW, Brisco-Bacik MA, Chen HH, et al.: Worsening renal function in patients with acute heart failure undergoing aggressive diuresis is not associated with tubular injury. Circulation 137: 20162028, 2018 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22.

    Rao VS, Ahmad T, Brisco-Bacik MA, Bonventre JV, Wilson FP, Siew ED, et al.: Renal effects of intensive volume removal in heart failure patients with preexisting worsening renal function. Circ Heart Fail 12: e005552, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23.

    Ou S-M, Tsai M-T, Chen H-Y, Li F-A, Tseng W-C, Lee K-H, et al.: Identification of galectin-3 as potential biomarkers for renal fibrosis by RNA-sequencing and clinicopathologic findings of kidney biopsy. Front Med (Lausanne) 8: 748225, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24.

    Rao VS, Ivey-Miranda JB, Cox ZL, Moreno-Villagomez J, Testani JM: Association of urine galectin-3 with cardiorenal outcomes in patients with heart failure. J Card Fail 30: 340346, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25.

    Núñez J, de la Espriella R, Miñana G, Santas E, Llácer P, Núñez E, et al.: Antigen carbohydrate 125 as a biomarker in heart failure: A narrative review. Eur J Heart Fail 23: 14451457, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Docherty KF, McDowell K, Welsh P, Osmanska J, Anand I, de Boer RA, et al.: Association of carbohydrate antigen 125 on the response to dapagliflozin in patients with heart failure. J Am Coll Cardiol 82: 142157, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27.

    Accardi AJ, Matsubara BS, Gaw RL, Daleiden-Burns A, Heywood JT: Clinical utility of fluid volume assessment in heart failure patients using bioimpedance spectroscopy. Front Cardiovasc Med 8: 636718, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28.

    de la Espriella R, Núñez-Marín G, Cobo M, de Castro Campos D, Llácer P, Manzano L, et al.: Intrarenal venous flow pattern changes do relate with renal function alterations in acute heart failure. JACC Heart Fail 12: 304318, 2024 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 29.

    Trpkov C, Grant ADM, Fine NM: Intrarenal Doppler ultrasound renal venous stasis index correlates with acute cardiorenal syndrome in patients with acute decompensated heart failure. CJC Open 3: 14441452, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 30.

    Griffin M, Ivey-Miranda J, McCallum W, Sarnak M, Eder M, Bellumkonda L, et al.: Inferior vena cava diameter measurement provides distinct and complementary information to right atrial pressure in acute decompensated heart failure. J Card Fail 28: 12171221, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31.

    Sheridan WS, Wetterling F, Testani JM, Borlaug BA, Fudim M, Damman K, et al.: Safety and performance of a novel implantable sensor in the inferior vena cava under acute and chronic intravascular volume modulation. Eur J Heart Fail 25: 754763, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 32.

    Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al.: 2022 AHA/ACC/HFSA guideline for the management of heart failure: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 145: e895e1032, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 33.

    Raval NY, Valika A, Adamson PB, Williams C, Brett ME, Costanzo MR: Pulmonary artery pressure-guided heart failure management reduces hospitalizations in patients with chronic kidney disease. Circ Heart Fail 16: e009721, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 34.

    Vaduganathan M, Docherty KF, Claggett BL, Jhund PS, de Boer RA, Hernandez AF, et al.: SGLT-2 inhibitors in patients with heart failure: A comprehensive meta-analysis of five randomised controlled trials. Lancet 400: 757767, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35.

    Voors AA, Angermann CE, Teerlink JR, Collins SP, Kosiborod M, Biegus J, et al.: The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: A multinational randomized trial. Nat Med 28: 568574, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 36.

    Schulze PC, Bogoviku J, Westphal J, Aftanski P, Haertel F, Grund S, et al.: Effects of early empagliflozin initiation on diuresis and kidney function in patients with acute decompensated heart failure (EMPAG-HF). Circulation 146: 289298, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 37.

    Tamaki S, Yamada T, Watanabe T, Morita T, Furukawa Y, Kawasaki M, et al.: Effect of empagliflozin as an add-on therapy on decongestion and renal function in patients with diabetes hospitalized for acute decompensated heart failure: A prospective randomized controlled study. Circ Heart Fail 14: e007048, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 38.

    Aklilu AM, Kumar S, Yamamoto Y, Moledina DG, Sinha F, Testani JM, et al.: Outcomes associated with sodium-glucose cotransporter-2 inhibitor use in acute heart failure hospitalizations complicated by AKI. Kidney360 4: 13711381, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 39.

    Rao VS, Ivey-Miranda JB, Cox ZL, Moreno-Villagomez J, Maulion C, Bellumkonda L, et al.: Empagliflozin in heart failure: Regional nephron sodium handling effects. J Am Soc Nephrol 35: 189201, 2024 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 40.

    Mullens W, Dauw J, Martens P, Verbrugge FH, Nijst P, Meekers E, et al.; ADVOR Study Group: Acetazolamide in acute decompensated heart failure with volume overload. N Engl J Med 387: 11851195, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 41.

    Martens P, Verbrugge FH, Dauw J, Nijst P, Meekers E, Augusto SN, et al.: Pre-treatment bicarbonate levels and decongestion by acetazolamide: The ADVOR trial. Eur Heart J 44: 19952005, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 42.

    Meekers E, Dauw J, Martens P, Dhont S, Verbrugge FH, Nijst P, et al.: Renal function and decongestion with acetazolamide in acute decompensated heart failure: The ADVOR trial. Eur Heart J 44: 36723682, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 43.

    Trullàs JC, Morales-Rull JL, Casado J, Carrera-Izquierdo M, Sánchez-Marteles M, Conde-Martel A, et al.; CLOROTIC trial investigators: Combining loop with thiazide diuretics for decompensated heart failure: The CLOROTIC trial. Eur Heart J 44: 411421, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 44.

    Trullàs JC, Morales-Rull JL, Casado J, Carrera-Izquierdo M, Sánchez-Marteles M, Conde-Martel A, et al.: Combining loop and thiazide diuretics for acute heart failure across the estimated glomerular filtration rate spectrum: A post-hoc analysis of the CLOROTIC trial. Eur J Heart Fail 25: 17841793, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 45.

    McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, ESC Scientific Document Group, et al.: 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure of the European Society of Cardiology (ESC) with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 42: 35993726, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 46.

    Verbrugge FH, Martens P, Dauw J, Nijst P, Meekers E, Augusto SN, et al.: Natriuretic response to acetazolamide in patients with acute heart failure and volume overload. J Am Coll Cardiol 81: 20132024, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 47.

    Dauw J, Charaya K, Lelonek M, Zegri-Reiriz I, Nasr S, Paredes-Paucar CP, et al.: Protocolized natriuresis-guided decongestion improves diuretic response: The Multicenter ENACT-HF study. Circ Heart Fail 17: e011105, 2024 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 48.

    Ter Maaten JM, Beldhuis IE, van der Meer P, Krikken JA, Postmus D, Coster JE, et al.: Natriuresis-guided diuretic therapy in acute heart failure: A pragmatic randomized trial. Nat Med 29: 26252632, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 49.

    Rao VS, Ivey-Miranda JB, Cox ZL, Riello R, Griffin M, Fleming J, et al.: Natriuretic equation to predict loop diuretic response in patients with heart failure. J Am Coll Cardiol 77: 695708, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 50.

    Chen S, Wang H, Ning B: Efficacy and safety of early ultrafiltration in patients with acute decompensated heart failure: A meta-analysis. Front Cardiovasc Med 10: 1234092, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 51.

    Wang MJ, Zheng YM, Jin HX: Ultrafiltration for patients with acute decompensated heart failure: A systematic review and meta-analysis. Medicine (Baltimore) 100: e28029, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 52.

    Sarnak MJ, Auguste BL, Brown E, Chang AR, Chertow GM, Hannan M, et al.; American Heart Association Council on the Kidney in Cardiovascular Disease; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular Radiology and Intervention; Council on Clinical Cardiology; Council on Hypertension; and Council on Lifestyle and Cardiometabolic Health: Cardiovascular effects of home dialysis therapies: A scientific statement from the American Heart Association. Circulation 146: e146e164, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 53.

    Teerlink JR, Diaz R, Felker GM, McMurray JJV, Metra M, Solomon SD, et al.: Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction: Rationale and design of GALACTIC-HF. JACC Heart Fail 8: 329340, 2020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 54.

    Cuffe MS, Califf RM, Adams KF, Benza R, Bourge R, Colucci WS, et al.; Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) Investigators: Short-term intravenous milrinone for acute exacerbation of chronic heart failure: A randomized controlled trial. JAMA 287: 15411547, 2002 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 55.

    Metra M, Pagnesi M, Claggett BL, Díaz R, Felker GM, McMurray JJV, et al.: Effects of omecamtiv mecarbil in heart failure with reduced ejection fraction according to blood pressure: The GALACTIC-HF trial. Eur Heart J 43: 50065016, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 56.

    Geller BJ, Sinha SS, Kapur NK, Bakitas M, Balsam LB, Chikwe J, et al.; American Heart Association Acute Cardiac Care and General Cardiology Committee of the Council on Clinical Cardiology; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Peripheral Vascular Disease; and Council on Cardiovascular Surgery and Anesthesia: Escalating and de-escalating temporary mechanical circulatory support in cardiogenic shock: A scientific statement from the American Heart Association. Circulation 146: e50e68, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 57.

    Cowger JA, Basir MB, Baran DA, Hayward CS, Rangaswami J, Walton A, et al.; Aortix CRS Pilot Study Investigators: Safety and performance of the Aortix device in acute decompensated heart failure and cardiorenal syndrome. Jacc Heart Fail 11: 15651575, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 58.

    Grafton G, Tita C, Heuring JJ, Fain ES, Shah P, Cowger JA, et al.: Continuous-flow intra-aortic percutaneous mechanical circulatory support in heart failure with worsening renal function. Circ Heart Fail 16: e009842, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 59.

    Kapur NK, Reyelt L, Crowley P, Richey L, McCarthy J, Annamalai S, et al.: Intermittent occlusion of the superior vena cava reduces cardiac filling pressures in preclinical models of heart failure. J Cardiovasc Transl Res 13: 151157, 2020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 60.

    Zymliński R, Biegus J, Vanderheyden M, Gajewski P, Dierckx R, Bartunek J, et al.: Safety, feasibility of controllable decrease of vena cava pressure by Doraya catheter in heart failure. Jacc Basic Transl Sci 8: 394402, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 61.

    Abraham WT, Jonas M, Dongaonkar RM, Geist B, Ueyama Y, Render K, et al.: Direct interstitial decongestion in an animal model of acute-on-chronic ischemic heart failure. JACC Basic Transl Sci 6: 872881, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 62.

    Rao VS, Maulion C, Asher JL, Ivey-Miranda JB, Cox ZL, Moreno-Villagomez J, et al.: Renal negative pressure treatment as a novel therapy for heart failure-induced renal dysfunction. Am J Physiol Regul Integr Comp Physiol 321: R588R594, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 63.

    McCallum W, Sarnak MJ: Cardiorenal syndrome in the hospital. Clin J Am Soc Nephrol 18: 933945, 2023 PubMed

Metrics

All Time Past Year Past 30 Days
Abstract Views 201 201 201
Full Text Views 90 90 90
PDF Downloads 122 122 122