Congenital Anomalies of the Kidney and Urinary Tract
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Matthew Satariano College of Medicine, Northeastern Ohio Medical University, Rootstown, Ohio

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Angelina Dixon Division of Renal Diseases and Hypertension and Division of Pediatric Nephrology, University of Colorado Denver, Aurora, Colorado

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Cozumel Pruette Division of Pediatric Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland

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  • 1.

    Murugapoopathy V, Gupta IR: A primer on congenital anomalies of the kidneys and urinary tracts (CAKUT). Clin J Am Soc Nephrol 15: 723731, 2020 PubMed

  • 2.

    Stonebrook E, Hoff M, Spencer JD: Congenital anomalies of the kidney and urinary tract: A clinical review. Curr Treat Options Pediatr 5: 223235, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Raina R, Chakraborty R, Sethi SK, Kumar D, Gibson K, Bergmann C: Diagnosis and management of renal cystic disease of the newborn: Core curriculum 2021. Am J Kidney Dis 78: 125141, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Hamilton AJ, Braddon F, Casula A, Lewis M, Mallett T, Marks SD, et al.: UK Renal Registry 19th annual report: Chapter 4 Demography of the UK paediatric renal replacement therapy population in 2015. Nephron 137[Suppl 1]: 103116, 2017 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Martz K, Stablein D: North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS), 2008. Available at: https://naprtcs.org/system/files/2008_Annual_CKD_Report.pdf. Accessed February 26, 2024

    • PubMed
    • Export Citation
  • 6.

    UK Kidney Association: UK Renal Registry 25th Annual Report, 2023. Available at: https://ukkidney.org/audit-research/annual-report. Accessed February 26, 2024

    • PubMed
    • Export Citation
  • 7.

    Harada R, Hamasaki Y, Okuda Y, Hamada R, Ishikura K: Epidemiology of pediatric chronic kidney disease/kidney failure: Learning from registries and cohort studies. Pediatr Nephrol 37: 12151229, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Harambat J, Bonthuis M, Groothoff JW, Schaefer F, Tizard EJ, Verrina E, et al.: Lessons learned from the ESPN/ERA-EDTA Registry. Pediatr Nephrol 31: 20552064, 2016 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Knoers NVAM: The term CAKUT has outlived its usefulness: The case for the defense. Pediatr Nephrol 37: 27932798, 2022 PubMed

  • 10.

    Subcommittee on Urinary Tract Infection: Reaffirmation of AAP clinical practice guideline: The diagnosis and management of the initial urinary tract infection in febrile infants and young children 2–24 months of age. Pediatrics 138: e20163026, 2016 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Talati AN, Webster CM, Vora NL: Prenatal genetic considerations of congenital anomalies of the kidney and urinary tract (CAKUT). Prenat Diagn 39: 679692, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Deshpande C, Hennekam RCM: Genetic syndromes and prenatally detected renal anomalies. Semin Fetal Neonatal Med 13: 171180, 2008 PubMed

  • 13.

    Bonsib SM: Renal hypoplasia, from grossly insufficient to not quite enough: Consideration for expanded concepts based upon the author’s perspective with historical review. Adv Anat Pathol 27: 311330, 2020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Broyer M, Soto B, Gagnadoux MF, Adi M, Rica C, Gubler MC: Oligomeganephronic renal hypoplasia. Adv Nephrol Necker Hosp 26: 4763, 1997 PubMed

  • 15.

    Gaffar S, Arora P, Ramanathan R: Late preterm infant with postnatal diagnosis of renal tubular dysgenesis. J Investig Med High Impact Case Rep 10:10.1177/23247096221111775, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Yener S, Pehlivanoğlu C, Akis Yıldız Z, Ilce HT, Ilce Z: Duplex kidney anomalies and associated pathologies in children: A single-center retrospective review. Cureus 14: e25777, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Decter RM: Renal duplication and fusion anomalies. Pediatr Clin North Am 44: 13231341, 1997 PubMed

  • 18.

    Kullendorff CM, Wallin L: DMSA scintigraphy in renal duplex system. Eur J Pediatr Surg 3: 8386, 1993 PubMed

  • 19.

    Whitten SM, Wilcox DT: Duplex systems. Prenat Diagn 21: 952957, 2001

  • 20.

    Anand S, Lotfollahzadeh S: Bladder exstrophy, 2023. Available at: https://www.ncbi.nlm.nih.gov/books/NBK563156/. Accessed February 26, 2024

    • PubMed
    • Export Citation
  • 21.

    Taghavi K, Sharpe C, Stringer MD: Fetal megacystis: A systematic review. J Pediatr Urol 13: 715, 2017 PubMed

  • 22.

    Rodriguez MM: Congenital anomalies of the kidney and the urinary tract (CAKUT). Fetal Pediatr Pathol 33: 293320, 2014 PubMed

  • 23.

    Sananes N, Cruz-Martinez R, Favre R, Ordorica-Flores R, Moog R, Zaloszy A, et al.: Two-year outcomes after diagnostic and therapeutic fetal cystoscopy for lower urinary tract obstruction. Prenat Diagn 36: 297303, 2016 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24.

    Cordido A, Vizoso-Gonzalez M, Garcia-Gonzalez MA: Molecular pathophysiology of autosomal recessive polycystic kidney disease. Int J Mol Sci 22: 6523, 2021 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25.

    Raina R, Houry A, Rath P, Mangat G, Pandher D, Islam M, et al.: Clinical utility and tolerability of tolvaptan in the treatment of autosomal dominant polycystic kidney disease (ADPKD). Drug Healthc Patient Saf 14: 147159, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Krishnappa V, Vinod P, Deverakonda D, Raina R: Autosomal dominant polycystic kidney disease and the heart and brain. Cleve Clin J Med 84: 471481, 2017 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27.

    Walker EYX, Marlais M: Should we screen for intracranial aneurysms in children with autosomal dominant polycystic kidney disease? Pediatr Nephrol 38: 7785, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28.

    Pfeferman MB, Rocha DRD, Rodrigues FG, Pfeferman E, Heilberg IP: Echocardiographic abnormalities in autosomal dominant polycystic kidney disease (ADPKD) patients. J Clin Med 11: 5982, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 29.

    Mekahli D, Guay-Woodford LM, Cadnapaphornchai MA, Greenbaum LA, Litwin M, Seeman T, et al.: Tolvaptan for children and adolescents with autosomal dominant polycystic kidney disease: Randomized controlled trial. Clin J Am Soc Nephrol 18: 3646, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 30.

    Gimpel C, Bergmann C, Bockenhauer D, Breysem L, Cadnapaphornchai MA, Cetiner M, et al.: International consensus statement on the diagnosis and management of autosomal dominant polycystic kidney disease in children and young people. Nat Rev Nephrol 15: 713726, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31.

    Gitomer BY, Wang W, George D, Coleman E, Nowak KL, Struemph T, et al.: Statin therapy in patients with early-stage autosomal dominant polycystic kidney disease: Design and baseline characteristics. Contemp Clin Trials 137: 107423, 2023

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 32.

    Nishimura H, Yerkes E, Hohenfellner K, Miyazaki Y, Ma J, Hunley TE, et al.: Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell 3: 110, 1999 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 33.

    Oshima K, Miyazaki Y, Brock JW 3rd, Adams MC, Ichikawa I, Pope JC 4th: Angiotensin type II receptor expression and ureteral budding. J Urol 166: 18481852, 2001 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 34.

    Ichikawa I, Kuwayama F, Pope JC 4th, Stephens FD, Miyazaki Y: Paradigm shift from classic anatomic theories to contemporary cell biological views of CAKUT. Kidney Int 61: 889898, 2002 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35.

    Woolf AS: The term CAKUT has outlived its usefulness: The case for the prosecution. Pediatr Nephrol 37: 27852791, 2022 PubMed

  • 36.

    Hiraoka M, Taniguchi T, Nakai H, Kino M, Okada Y, Tanizawa A, et al.: No evidence for AT2R gene derangement in human urinary tract anomalies. Kidney Int 59: 12441249, 2001 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 37.

    Nicolaou N, Renkema KY, Bongers EMHF, Giles RH, Knoers NVAM: Genetic, environmental, and epigenetic factors involved in CAKUT. Nat Rev Nephrol 11: 720731, 2015 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 38.

    Mañalich R, Reyes L, Herrera M, Melendi C, Fundora I: Relationship between weight at birth and the number and size of renal glomeruli in humans: A histomorphometric study. Kidney Int 58: 770773, 2000 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 39.

    Dart AB, Ruth CA, Sellers EA, Au W, Dean HJ: Maternal diabetes mellitus and congenital anomalies of the kidney and urinary tract (CAKUT) in the child. Am J Kidney Dis 65: 684691, 2015 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 40.

    Gray SP, Denton KM, Cullen-McEwen L, Bertram JF, Moritz KM: Prenatal exposure to alcohol reduces nephron number and raises blood pressure in progeny. J Am Soc Nephrol 21: 18911902, 2010 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 41.

    Battin M, Albersheim S, Newman D: Congenital genitourinary tract abnormalities following cocaine exposure in utero. Am J Perinatol 12: 425428, 1995 PubMed

  • 42.

    Groen In ’t Woud S, Roeleveld N, van Rooij IALM, Feitz WFJ, Schreuder MF, van der Zanden LFM; SOFIA study group: Environmental and parental risk factors for congenital solitary functioning kidney - A case-control study. Pediatr Nephrol 38: 26312641, 2023 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 43.

    van der Ven AT, Connaughton DM, Ityel H, Mann N, Nakayama M, Chen J, et al.: Whole-exome sequencing identifies causative mutations in families with congenital anomalies of the kidney and urinary tract. J Am Soc Nephrol 29: 23482361, 2018 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 44.

    Kerecuk L, Sajoo A, McGregor L, Berg J, Haq MR, Sebire NJ, et al.: Autosomal dominant inheritance of non-syndromic renal hypoplasia and dysplasia: dramatic variation in clinical severity in a single kindred. Nephrol Dial Transplant 22: 259263, 2007 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 45.

    Atkinson MA, Jelin EB, Baschat A, Blumenfeld YJ, Chmait RH, O’Hare E, et al.: Design and protocol of the Renal Anhydramnios Fetal Therapy (RAFT) trial. Clin Ther 44: 11611171, 2022 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 46.

    Gyamfi-Bannerman C, Marc-Aurele K, Mestan K: Bilateral renal agenesis—Interpreting the RAFT trial. JAMA 330: 20592060, 2023 PubMed

  • 47.

    Craig JC, Simpson JM, Williams GJ, Lowe A, Reynolds GJ, McTaggart SJ, et al.; Prevention of Recurrent Urinary Tract Infection in Children with Vesicoureteric Reflux and Normal Renal Tracts (PRIVENT) Investigators: Antibiotic prophylaxis and recurrent urinary tract infection in children. N Engl J Med 361: 17481759, 2009 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 48.

    Hoberman A, Greenfield SP, Mattoo TK, Keren R, Mathews R, Pohl HG, et al.; RIVUR Trial Investigators: Antimicrobial prophylaxis for children with vesicoureteral reflux. N Engl J Med 370: 23672376, 2014 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 49.

    Williams G, Craig JC: Long-term antibiotics for preventing recurrent urinary tract infection in children. Cochrane Database Syst Rev 2019: CD001534, 2019

  • 50.

    Sanna-Cherchi S, Ravani P, Corbani V, Parodi S, Haupt R, Piaggio G, et al.: Renal outcome in patients with congenital anomalies of the kidney and urinary tract. Kidney Int 76: 528533, 2009 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 51.

    Wühl E, van Stralen KJ, Verrina E, Bjerre A, Wanner C, Heaf JG, et al.: Timing and outcome of renal replacement therapy in patients with congenital malformations of the kidney and urinary tract. Clin J Am Soc Nephrol 8: 6774, 2013 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 52.

    Ritchie AG, Clayton PA, Mackie FE, Kennedy SE: Nationwide survey of adolescents and young adults with end-stage kidney disease. Nephrology (Carlton) 17: 539544, 2012 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 53.

    Forbes TA, Watson AR, Zurowska A, Shroff R, Bakkaloglu S, Vondrak K, et al.; European Paediatric Dialysis Working Group: Adherence to transition guidelines in European paediatric nephrology units. Pediatr Nephrol 29: 16171624, 2014 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation

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