Learning Objectives

• To describe the major causes of interstitial and cystic diseases in the kidney.
• To define for each the epidemiology, clinical presentation, prognosis, and treatment.
• TTo discuss the role of genetic screening in interstitial and cystic diseases.

It is the policy of the American Society of Nephrology (ASN) that all individuals in a position to control the content of ASN's educational activities are expected to disclose all their and their life spouse/partner's financial relationships with “ineligible companies” within the prior 24 months as well as other non-financial interests. (“Ineligible companies” are those whose primary business is producing, marketing, selling, re-selling, or distributing health care products used by or on patients.) Participants should note that the use of products outside U.S. Food and Drug Administration (FDA) approved labeling should be considered experimental and are advised to consult current prescribing information for approval indications.

The intent of this policy is not to prevent expert faculty with relevant relationship(s) with commercial interest(s) from involvement in educational activities, but rather to ensure that these activities promote quality and safety, are effective in improving medical practice, are based on valid content, and are independent of control from commercial interests and free of commercial bias. In addition, all faculty were instructed to provide balanced, scientifically rigorous, and evidence-based presentations.

ASN requires all individuals in a position to control content for this activity to complete disclosure forms on the ASN website. Responses are listed below.

Disclosures have been reviewed and assessed by ASN. All relationships with ineligible companies have been identified and all relevant financial relationships have been mitigated.

View the full ASN Conflict of Interest and Disclosure Policy: https://www.asn-online.org/education/cme/coi-disclosure.pdf.

EDITORS:

Alice M. Sheridan, MD—Employer(s): Brigham and Women’s Hospital; No additional relevant financial relationship(s) with ineligible companies to disclose.

Martina M. McGrath, MBChB, FASN—Employer(s): Brigham and Women’s Hospital; VA Boston Medical Center; No additional relevant financial relationship(s) with ineligible companies to disclose.

EDITORIAL AUTHOR:

Mark A. Perazella, MD, MS, FASN—Employer(s): Yale University School of Medicine; Honoraria: UpToDate; Advisory or Leadership Role: Kidney360 (Deputy Editor), Journal of Ono-Nephrology (Co-Editor-in-Chief), Clinical Nephrology (AKI Series Editor), CJASN, KI, and KI Reports (Editorial Board).

AUTHORS:

Oshorenua Aiyegbusi, MBBS—Employer(s): NHS GGC; University of British Columbia; No relevant financial relationship(s) with ineligible companies to disclose.

Sola Aoun Bahous, MD, PhD—Employer(s): Saint George Hospital University Medical Center; Advisory or Leadership Role: Academic Editor for “Medicine”; Associate Dean for Medical Education at Lebanese American University School of Medicine.

Abdallah S. Geara, MD—Employer(s): University of Pennsylvania; Consultancy: Aurinia; GSK; Valenzabio; Kaneka; Horizon; Chinook; Travere; Novartis; Vera; Research Funding: Travere; ValenzaBio; Aurinia; Amgen; Vera; Chinook; Honoraria: Kaneka; Aurinia; Calliditas.

Alexandre Hertig, MD, PhD—Employer(s): Sorbonne University; Consultancy: Sanofi Genzyme; Research Funding: Amgen; Honoraria: Sanofi.

Michael W. Holliday, Jr., MD, PhD, FASN—Employer(s): Baylor College of Medicine; Michael E. DeBakey VA Medical Center.

Rupesh Raina, MD, FASN—Employer(s): Cleveland Clinic at Akron Genera Medical Center.

Ivette Ruiz-Leija, MD—Employer(s): Hospital Central Dr. Ignacio Morones Prieto; No relevant financial relationship(s) with ineligible companies to disclose.

Matthew F. Satariano, BS—No relevant financial relationship(s) with ineligible companies to disclose.

David (Daud) Sheikh-Hamad, MD, FASN—Employer(s): Baylor College of Medicine; No relevant financial relationship(s) with ineligible companies to disclose.

Vicente E. Torres, MD, PhD—Employer(s): Mayo Clinic; Consultancy: Otsuka Pharmaceuticals; Sanofi; Palladio; Blueprint Medicines, Mironid, Reata, Regulus, Johnson & Johnson, Crinetics, Sonofi-Genzyme, Tribune Therapeutics [all payments to Mayo Foundation]; Research Funding: Otsuka Pharmaceuticals, Palladio Biosciences, Mironid, Sanofi Genzyme, Reata, Regulus, Tribune Therapeutics [all payments to Mayo Foundation].

Florent Von Tokarski, MD—Employer(s): H^opital Foch; No relevant financial relationship(s) with ineligible companies to disclose.

Julie Xia Zhou, MD, PhD—Employer(s): Mayo Clinic; No relevant financial relationship(s) with ineligible companies to disclose.

ASN STAFF:

Suzanne P. Armstrong, MA—Employer(s): American Society of Nephrology; No relevant financial relationship(s) with ineligible companies to disclose.

Commercial Support

There is no commercial support for this issue.

The nephSAP editorial team and the KSAP editorial board extend their sincere appreciation to the following reviewers. Their efforts and insights help improve the quality of these postgraduate education offerings. 

nephSAP Review Panel, Volume 22, Number 3, December 2023

• Farsad Afshinnia, MD, MS, FASN University of Michigan UNITED STATES
• Gopal Basu, MD, MBBS, FASN
• Alfred Hospital,Monash University AUSTRALIA
• Shirley Shwu-Shiow Chang, MD, FASN SUNY Buffalo UNITED STATES
• Joshua Kaplan, MD, FASN Rutgers New Jersey Medical School UNITED STATES
• Eleanor D. Lederer, MD, FASN UT Southwestern Medical Center UNITED STATES
• Vidooshi G. Maru,MD Nephrology Associates of Michigan, PC UNITED STATES
• Kerri A. McGreal,MD University of Kansas School of Medicine UNITED STATES
• Ashraf I. Mikhail,MD Morriston Hospital UNITED KINGDOM
• Dennis G. Moledina, MD, PhD, FASN Yale School of Medicine UNITED STATES
• Cynthia C. Nast, MD, FASN Cedars-Sinai Medical Center UNITED STATES
• Georges Ouellet,MD Centre de recherche de l’H^opital Maisonneuve-Rosemont CANADA
• Pairach Pintavorn, MD, FASN East Georgia Kidney Group UNITED STATES
• Anastasia Ptinopoulou, MD, PhD General Hospital of Lemnos GREECE
• Hernan Rincon-Choles, MD, MS, FASN Cleveland Clinic UNITED STATES
• Jorge Enrique Rojas-Rivera,MD Hospital Universitario Fundacion Jimenez Dıaz SPAIN
• Hitesh H. Shah, MD, FASN Zucker School of Medicine at Hofstra/Northwell UNITED STATES
• Mwf van den Hoogen, MD, PhD Erasmus MC Rotterdam NETHERLANDS
• Julie M. Yabu, MD, MS, FASN David Geffen School of Medicine at UCLA UNITED STATES
• Michifumi Yamashita, MD, PhD, FASN Cedars-Sinai Medical Center UNITED STATES
• Brian Y. Young, MD, FASN UC Davis Medical Center UNITED STATES

Program Mission and Objectives

nephSAP® provides a learning vehicle for physicians, scientists, advanced practitioners, nurses, pharmacists, and other health professionals working and training in the field of nephrology to renew and refresh their clinical knowledge, diagnostic, and therapeutic skills. This enduring material provides learners challenging, clinically-oriented questions based on case vignettes, detailed learning objectives, a series of articles that review recent publications, and an editorial on an important and evolving topic. This combination of materials enables learners to rigorously assess their strengths and weaknesses in the broad domain of nephrology.

Target Audience

Physicians, scientists, advanced practitioners, nurses, pharmacists, and other health professionals working and training in the field of nephrology.

Accreditation Statements

In support of improving patient care, the American Society of Nephrology is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

AMA Credit Designation Statement – Physicians: The American Society of Nephrology designates this internet activity (enduring material) for a maximum of 10.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ABIM MOC Statement

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 10.0 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to Joint Accreditation for the purpose of granting ABIM MOC credit. MOC points will be applied to only those ABIM candidates who have enrolled in the MOC program. It is your responsibility to complete the ABIM MOC enrollment process.

Original Release Date: December 2023

CME/MOC Termination Date: November 30, 2025 at 11:59 pm ET

Examination Available Online: On or before December 31, 2023

Estimated Time for Completion: 10 hours 

Self-Assessment Examination

• Answers with explanations are provided with a passing score after the first and/or second attempt
• This issue will be archived December 1, 2025, and answers with explanations will be posted on the ASN website

Method of Participation

• Read the entire issue that is supplemented by original articles in the reference lists.
• Complete the online self-assessment examination.
• Each participant is allowed two attempts to pass the examination (75% correct) for CME and MOC.
• Upon completion, review your score and incorrect answers and print your certificate.

Activity Evaluation, CE, and MOC

• Go to ASN eLEARNING CENTER (education.asn-online.org)
• Select MY ACTIVITIES from the left-hand navigation.
• Select the corresponding issue.
• Read all information on the Overview screen.
• Follow the onscreen instructions to:
  • Complete the Exam (i.e., post test),
  • Complete the Evaluation,
  • Claim credit/MOC, and
  • IMPORTANT: select the credit type that corresponds with your designation, and
  • Print a Certificate

Your ASN Transcript is available on the ASN website:

• Go to the ASN website and log in to your ASN Profile page
• Select the CME/CE Transcript tab
• View credits claimed or print a certificate with continuing education information for completed learning activities