Calciphylaxis and Vascular Calcification in Patients with CKD
By:
Sagar U. Nigwekar Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

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  • 1.

    Gallo Marin B, Aghagoli G, Hu SL, Massoud CM, Robinson-Bostom L: Calciphylaxis and kidney disease: A review. Am J Kidney Dis 81: 232239, 2022 PubMed

  • 2.

    Nigwekar SU, Thadhani R, Brandenburg VM: Calciphylaxis. N Engl J Med 378: 17041714, 2018 PubMed

  • 3.

    Sutton NR, Malhotra R, St Hilaire C, Aikawa E, Blumenthal RS, Gackenbach G, et al.: Molecular mechanisms of vascular health: Insights from vascular aging and calcification. Arterioscler Thromb Vasc Biol 43: 1529, 2023 PubMed

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    Kaur R, Singh R. Mechanistic insights into CKD-MBD-related vascular calcification and its clinical implications. Life Sci 311: 121148, 2022

  • 5.

    Dutta P, Chaudet KM, Nazarian RM, Kroshinsky D, Nigwekar SU: Correlation between clinical and pathological features of cutaneous calciphylaxis. PLoS One 14: e0218155, 2019 PubMed

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  • 6.

    Gabel CK, Blum AE, François J, Chakrala T, Dobry AS, Garza-Mayers AC, et al.: Clinical mimickers of calciphylaxis: A retrospective study. J Am Acad Dermatol 85: 15201527, 2021 PubMed

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  • 8.

    Brandenburg VM, Kramann R, Rothe H, Kaesler N, Korbiel J, Specht P, et al.: Calcific uraemic arteriolopathy (calciphylaxis): Data from a large nationwide registry. Nephrol Dial Transplant 32: 126132, 2017 PubMed

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  • 9.

    Nigwekar SU, Zhao S, Wenger J, Hymes JL, Maddux FW, Thadhani RI, et al.: A nationally representative study of calcific uremic arteriolopathy risk factors. J Am Soc Nephrol 27: 34213429, 2016 PubMed

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    McCarthy JT, El-Azhary RA, Patzelt MT, Weaver AL, Albright RC, Bridges AD, et al.: Survival, risk factors, and effect of treatment in 101 patients with calciphylaxis. Mayo Clin Proc 91: 13841394, 2016 PubMed

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  • 12.

    Bajaj R, Courbebaisse M, Kroshinsky D, Thadhani RI, Nigwekar SU: Calciphylaxis in patients with normal renal function: A case series and systematic review. Mayo Clin Proc 93: 12021212, 2018 PubMed

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  • 13.

    Nigwekar SU, Wolf M, Sterns RH, Hix JK: Calciphylaxis from nonuremic causes: A systematic review. Clin J Am Soc Nephrol 3: 11391143, 2008 PubMed

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    Nigwekar SU, Kroshinsky D, Nazarian RM, Goverman J, Malhotra R, Jackson VA, et al.: Calciphylaxis: Risk factors, diagnosis, and treatment. Am J Kidney Dis 66: 133146, 2015 PubMed

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    Nigwekar SU, Solid CA, Ankers E, Malhotra R, Eggert W, Turchin A, et al.: Quantifying a rare disease in administrative data: The example of calciphylaxis. J Gen Intern Med 29: S724S731, 2014 PubMed

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  • 22.

    Nigwekar SU, Bhan I, Turchin A, Skentzos SC, Hajhosseiny R, Steele D, et al.: Statin use and calcific uremic arteriolopathy: A matched case-control study. Am J Nephrol 37: 325332, 2013 PubMed

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  • 23.

    Nigwekar SU, Nazarian RM: Cutaneous calcification in patients with kidney disease is not always calciphylaxis. Kidney Int 94: 244246, 2018 PubMed

  • 24.

    Jang A, Mark Ho MH, Yan L: Characterization of risk factors for calciphylaxis in hemodialysis patients in the fraser health renal program: A matched case-control retrospective Review [published online ahead of print Aug 28, 2022. J Pharm Pract doi:10.1177/08971900221118444 PubMed

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    Hayashi M: Calciphylaxis: diagnosis and clinical features. Clin Exp Nephrol 17: 498503, 2013 PubMed

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    Brandenburg VM, Kramann R, Rothe H, et al.: Calcific uraemic arteriolopathy (calciphylaxis): Data from a large nationwide registry. Nephrol Dial Transplant 32: 126132, 2017 PubMed

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  • 27.

    Panchal S, Holtermann K, Trivedi N, Regunath H, Yerram P: Calciphylaxis: An analysis of concomitant factors, treatment effectiveness and prognosis in 30 patients. Int J Nephrol Renovasc Dis 13: 6571, 2020 PubMed

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  • 28.

    Gaisne R, Péré M, Menoyo V, Hourmant M, Larmet-Burgeot D: Calciphylaxis epidemiology, risk factors, treatment and survival among French chronic kidney disease patients: A case-control study. BMC Nephrol 21: 63, 2020 PubMed

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  • 29.

    Zhang Y, Corapi KM, Luongo M, Thadhani R, Nigwekar SU: Calciphylaxis in peritoneal dialysis patients: A single center cohort study. Int J Nephrol Renovasc Dis 9: 235241, 2016 PubMed

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  • 30.

    Chinnadurai R, Huckle A, Hegarty J, Kalra PA, Sinha S: Calciphylaxis in end-stage kidney disease: Outcome data from the United Kingdom Calciphylaxis Study. J Nephrol 34: 15371545, 2021 PubMed

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  • 31.

    Hayashi M, Takamatsu I, Kanno Y, Yoshida T, Abe T, Sato Y; Japanese Calciphylaxis Study Group: A case-control study of calciphylaxis in Japanese end-stage renal disease patients. Nephrol Dial Transplant 27: 15801584, 2012 PubMed

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    Liu Y, Zhang X, Xie X, Yang X, Liu H, Tang R, et al.: Risk factors for calciphylaxis in Chinese hemodialysis patients: A matched case-control study. Ren Fail 43: 406416, 2021 PubMed

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  • 39.

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    Nigwekar SU, Bloch DB, Nazarian RM, Vermeer C, Booth SL, Xu D, et al.: Vitamin K-dependent carboxylation of matrix Gla protein influences the risk of calciphylaxis. J Am Soc Nephrol 28: 17171722, 2017 PubMed

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    Nigwekar SU, Thadhani R: Long-term anticoagulation for patients receiving dialysis. Circulation 138: 15301533, 2018 PubMed

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    Cozzolino M, Mangano M, Galassi A, Ciceri P, Messa P, Nigwekar S: Vitamin K in chronic kidney disease. Nutrients 11: 168, 2019 PubMed

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    Portales-Castillo I, Kroshinsky D, Malhotra CK, Culber-Costley R, Cozzolino MG, Karparis S, et al.: Calciphylaxis-as a drug induced adverse event. Expert Opin Drug Saf 18: 2935, 2019 PubMed

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    Nigwekar SU, Jiramongkolchai P, Wunderer F, Bloch E, Ichinose R, Nazarian RM, et al.: Increased bone morphogenetic protein signaling in the cutaneous vasculature of patients with calciphylaxis. Am J Nephrol 46: 429438, 2017 PubMed

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    Paul S, Rabito CA, Vedak P, Nigwekar SU, Kroshinsky D: The role of bone scintigraphy in the diagnosis of calciphylaxis. JAMA Dermatol 153: 101103, 2017 PubMed

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