Renal Osteodystrophy and Bone Biopsy
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Ana Carina Ferreira Nephrology Department – Hospital Curry Cabral, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
NOVA Medical School – Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisbon, Portugal

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Aníbal Ferreira Nephrology Department – Hospital Curry Cabral, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal
NOVA Medical School – Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisbon, Portugal

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  • 1.

    Cannata-Andía JB, Martín-Carro B, Martín-Vírgala J, Rodríguez-Carrio J, Bande-Fernández JJ, Alonso-Montes C, et al.: Chronic kidney disease-mineral and bone disorders: Pathogenesis and management. Calcif Tissue Int 108: 410422, 2021 PubMed

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  • 3.

    Moe S, Drüeke T, Cunningham J, Goodman W, Martin K, Olgaard K, et al.; Kidney Disease: Improving Global Outcomes (KDIGO): Definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: Improving global outcomes (KDIGO). Kidney Int 69: 19451953, 2006 PubMed

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    Nickolas TL: The quest for better biomarkers of bone turnover in CKD. J Am Soc Nephrol 29: 13531355, 2018 PubMed

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    Evenepoel P, D’Haese P, Bacchetta J, Cannata-Andia J, Ferreira A, Haarhaus M, et al.; ERA-EDTA Working Group on CKD-MBD: Bone biopsy practice patterns across Europe: The European renal osteodystrophy initiative-a position paper. Nephrol Dial Transplant 32: 16081613, 2017 PubMed

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  • 6.

    Ferreira AC, Cohen-Solal M, D’Haese PC, Ferreira A; European Renal Osteodystrophy (EUROD), an initiative of the CKD-MBD working group of the ERA-EDTA: The role of bone biopsy in the management of CKD-MBD. Calcif Tissue Int 108: 528538, 2021 PubMed

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    Haarhaus M, Evenepoel P; European Renal Osteodystrophy (EUROD) workgroup; Chronic Kidney Disease Mineral and Bone Disorder (CKD-MBD) working group of the European Renal Association–European Dialysis and Transplant Association (ERA-EDTA): Differentiating the causes of adynamic bone in advanced chronic kidney disease informs osteoporosis treatment. Kidney Int 100: 546558, 2021 PubMed

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  • 17.

    Hernandes FR, Canziani ME, Barreto FC, Santos RO, Moreira VM, Rochitte CE, et al.: The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study. PLoS One 12: e0174811, 2017 PubMed

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    Neto R, Pereira L, Magalhães J, Quelhas-Santos J, Frazão J: Low bone turnover is associated with plain X-ray vascular calcification in predialysis patients. PLoS One 16: e0258284, 2021 PubMed

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  • 19.

    Ferreira AC, Cotovio P, Aires I, Mendes M, Navarro D, Silva C, et al.: The role of bone volume, FGF23 and sclerostin in calcifications and mortality; a cohort study in CKD stage 5 patients. Calcif Tissue Int 110: 215224, 2022 PubMed

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  • 20.

    Ferreira AC, Mendes M, Silva C, Cotovio P, Aires I, Navarro D, et al.: Improvement of mineral and bone disorders after renal transplantation. Transplantation 106: e251e261, 2022 PubMed

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  • 21.

    Kim DW, Hwang SY, Nam YJ, Kim D, Shin SJ, Yoon HE: The combined prognostic significance of alkaline phosphatase and vascular calcification in patients with end-stage kidney disease. Nutr Metab Cardiovasc Dis 30: 14761483, 2020 PubMed

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  • 22.

    Carbonara CEM, Reis LMD, Quadros KRDS, Roza NAV, Sano R, Carvalho AB, et al.: Renal osteodystrophy and clinical outcomes: Data from the Brazilian Registry of Bone Biopsies - REBRABO. J Bras Nefrol 42: 138146, 2020 PubMed

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  • 23.

    Novel-Catin E, Pelletier S, Fouque D, Roux JP, Chapurlat R, D’Haese P, et al.: Quantitative histomorphometric analysis of halved iliac crest bone biopsies yield comparable ROD diagnosis as full 7.5mm wide samples. Bone 138: 115460, 2020 PubMed

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    Steller Wagner Martins C, Jorgetti V, Moysés RMA: Time to rethink the use of bone biopsy to prevent fractures in patients with chronic kidney disease. Curr Opin Nephrol Hypertens 27: 243250, 2018 PubMed

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  • 25.

    Jørgensen HS, Behets G, Viaene L, Bammens B, Claes K, Meijers B, et al.: Static histomorphometry allows for a diagnosis of bone turnover in renal osteodystrophy in the absence of tetracycline labels. Bone 152: 116066, 2021 PubMed

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    Salam S, Gallagher O, Hughes D, Khwaja A, Eastell R: The role of static bone histomorphometry in diagnosing renal osteodystrophy. Bone 142: 115689, 2021 PubMed

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  • 27.

    Jørgensen HS, Ferreira AC, D’Haese P, Haarhaus M, Vervloet M, Lafage-Proust MH, et al.; European Renal Osteodystrophy (EUROD) workgroup; Chronic Kidney Disease - Mineral and Bone Disorder Working Group (CKD-MBD WG): Bone histomorphometry for the diagnosis of renal osteodystrophy: A call for harmonization of reference ranges. Kidney Int 102: 431434, 2022 PubMed

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    El-Husseini A, Nagy E, Barreto FC: Is bone histomorphometry required for assessment of renal osteodystrophy in clinical practice? Kidney Int 102: 670, 2022 PubMed

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