Acute Interstitial Nephritis and Crystalline Nephropathies
View More View Less
  • 1 Section of Nephrology and Clinical and Translational Research Accelerator, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut;
  • | 2 Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio; and
  • | 3 Section of Nephrology and Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut and Veterans Administration Medical Center, West Haven, Connecticut
  • 1

    Cortazar FB, Kibbelaar ZA, Glezerman IG, Abudayyeh A, Mamlouk O, Motwani SS, et al.: Clinical features and outcomes of immune checkpoint inhibitor-associated AKI: A multicenter study. J Am Soc Nephrol 31: 435446, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 2

    Jia Y, Su T, Gu Y, Li C, Zhou X, Su J, et al.: HLA-DQA1, -DQB1, and -DRB1 alleles associated with acute tubulointerstitial nephritis in a Chinese population: A single-center cohort study. J Immunol 201: 423431, 2018 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3

    Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, et al.: Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight 4: 4, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4

    Moledina DG, Wilson FP, Kukova L, Obeid W, Luciano R, Kuperman M, et al.: Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis. Nephrol Dial Transplant 36: 18511858, 2021 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5

    Muriithi AK, Nasr SH, Leung N: Utility of urine eosinophils in the diagnosis of acute interstitial nephritis. Clin J Am Soc Nephrol 8: 18571862, 2013 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6

    Goicoechea M, Rivera F, López-Gómez JM; Spanish Registry of Glomerulonephritis: Increased prevalence of acute tubulointerstitial nephritis. Nephrol Dial Transplant 28: 112115, 2013 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7

    Gesualdo L, Di Palma AM, Morrone LF, Strippoli GF, Schena FP; Italian Immunopathology Group, Italian Society of Nephrology: The Italian experience of the national registry of renal biopsies. Kidney Int 66: 890894, 2004 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8

    Ruffenach SJ, Siskind MS, Lien YHH: Acute interstitial nephritis due to omeprazole. Am J Med 93: 472473, 1992 PubMed

  • 9

    Muriithi AK, Leung N, Valeri AM, Cornell LD, Sethi S, Fidler ME, et al.: Clinical characteristics, causes and outcomes of acute interstitial nephritis in the elderly. Kidney Int 87: 458464, 2015 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 10

    Antoniou T, Macdonald EM, Hollands S, Gomes T, Mamdani MM, Garg AX, et al.: Proton pump inhibitors and the risk of acute kidney injury in older patients: A population-based cohort study. CMAJ Open 3: E166E171, 2015 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11

    Simpson IJ, Marshall MR, Pilmore H, Manley P, Williams L, Thein H, et al.: Proton pump inhibitors and acute interstitial nephritis: report and analysis of 15 cases. Nephrology (Carlton) 11: 381385, 2006 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 12

    Qato DM, Wilder J, Schumm LP, Gillet V, Alexander GC: Changes in prescription and over-the-counter medication and dietary supplement use among older adults in the United States, 2005 vs 2011. JAMA Intern Med 176: 473482, 2016 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 13

    Lazarus B, Chen Y, Wilson FP, Sang Y, Chang AR, Coresh J, et al.: Proton pump inhibitor use and the risk of chronic kidney disease. JAMA Intern Med 176: 238246, 2016 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 14

    Peng YC, Lin CL, Yeh HZ, Chang CS, Wu YL, Kao CH: Association between the use of proton pump inhibitors and the risk of ESRD in renal diseases: A population-based, case-control study. Medicine (Baltimore) 95: e3363, 2016 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 15

    Xie Y, Bowe B, Li T, Xian H, Balasubramanian S, Al-Aly Z: Proton pump inhibitors and risk of incident CKD and progression to ESRD. J Am Soc Nephrol 27: 31533163, 2016 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16

    Arora P, Gupta A, Golzy M, Patel N, Carter RL, Jalal K, et al.: Proton pump inhibitors are associated with increased risk of development of chronic kidney disease. BMC Nephrol 17: 112, 2016 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 17

    Moledina DG, Perazella MA: Proton pump inhibitors and CKD. J Am Soc Nephrol 27: 29262928, 2016 PubMed

  • 18

    Nochaiwong S, Ruengorn C, Awiphan R, Koyratkoson K, Chaisai C, Noppakun K, et al.: The association between proton pump inhibitor use and the risk of adverse kidney outcomes: A systematic review and meta-analysis. Nephrol Dial Transplant 33: 331342, 2018 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 19

    Helsby NA, Lo WY, Simpson IJ, Voss DM, Logan KE, Searle M, et al.: Omeprazole-induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype. Br J Clin Pharmacol 69: 516519, 2010 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 20

    Shirali AC, Perazella MA, Gettinger S: Association of acute interstitial nephritis with programmed cell death 1 inhibitor therapy in lung cancer patients. Am J Kidney Dis 68: 287291, 2016 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 21

    Cortazar FB, Marrone KA, Troxell ML, Ralto KM, Hoenig MP, Brahmer JR, et al.: Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors. Kidney Int 90: 638647, 2016 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 22

    Seethapathy H, Zhao S, Chute DF, Zubiri L, Oppong Y, Strohbehn I, et al.: The incidence, causes, and risk factors of acute kidney injury in patients receiving immune checkpoint inhibitors. Clin J Am Soc Nephrol 14: 16921700, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 23

    Manohar S, Kompotiatis P, Thongprayoon C, Cheungpasitporn W, Herrmann J, Herrmann SM: Programmed cell death protein 1 inhibitor treatment is associated with acute kidney injury and hypocalcemia: Meta-analysis. Nephrol Dial Transplant 34: 108117, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 24

    Muriithi AK, Leung N, Valeri AM, Cornell LD, Sethi S, Fidler ME, et al.: Biopsy-proven acute interstitial nephritis, 1993-2011: A case series. Am J Kidney Dis 64: 558566, 2014 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 25

    Su T, Gu Y, Sun P, Tang J, Wang S, Liu G, et al.: Etiology and renal outcomes of acute tubulointerstitial nephritis: A single-center prospective cohort study in China. Nephrol Dial Transplant 33: 11801188, 2018 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 26

    Caravaca-Fontán F, Shabaka A, Sánchez-Álamo B, de Lorenzo A, Díaz M, Blasco M, et al.; Spanish Group for the Study of Glomerular Diseases (GLOSEN): Recurrent acute interstitial nephritis: what lies beneath. Clin Kidney J 14: 197204, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 27

    Chu R, Li C, Wang S, Zou W, Liu G, Yang L: Assessment of KDIGO definitions in patients with histopathologic evidence of acute renal disease. Clin J Am Soc Nephrol 9: 11751182, 2014 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 28

    National Kidney Foundation: Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl 2: 1936, 2012

    • Search Google Scholar
    • Export Citation
  • 29

    Fogazzi GB, Ferrari B, Garigali G, Simonini P, Consonni D: Urinary sediment findings in acute interstitial nephritis. Am J Kidney Dis 60: 330332, 2012 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 30

    Perazella MA, Bomback AS: Urinary eosinophils in AIN: Farewell to an old biomarker? Clin J Am Soc Nephrol 8: 18411843, 2013 PubMed

  • 31

    Moledina DG, Eadon MT, Calderon F, Yamamoto Y, Shaw M, Perazella MA, et al.: Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data. Nephrol Dial Transplant 346: gfab346, 2021 10.1093/ndt/gfab346PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 32

    D’Agati VD, Theise ND, Pirani CL, Knowles DM, Appel GB: Interstitial nephritis related to nonsteroidal anti-inflammatory agents and beta-lactam antibiotics: A comparative study of the interstitial infiltrates using monoclonal antibodies. Mod Pathol 2: 390396, 1989 PubMed

    • Search Google Scholar
    • Export Citation
  • 33

    Zand L, Monaghan M, Griffin BR, Wagner SJ, Criaci IM, Kamal A, et al.: The role of type I hypersensitivity reaction and IgE-mediated mast cell activation in acute interstitial nephritis. Clin Nephrol 84: 138144, 2015 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 34

    Liapis H, Gaut JP, Klein C, Bagnasco S, Kraus E, Farris AB 3rd, et al.; Banff Working Group: Banff histopathological consensus criteria for preimplantation kidney biopsies. Am J Transplant 17: 140150, 2017 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 35

    Spanou Z, Keller M, Britschgi M, Yawalkar N, Fehr T, Neuweiler J, et al.: Involvement of drug-specific T cells in acute drug-induced interstitial nephritis. J Am Soc Nephrol 17: 29192927, 2006 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 36

    Berney-Meyer L, Hung N, Slatter T, Schollum JB, Kitching AR, Walker RJ: Omeprazole-induced acute interstitial nephritis: A possible Th1-Th17-mediated injury? Nephrology (Carlton) 19: 359365, 2014 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 37

    Sun PP, Zhou XJ, Su JQ, Wang C, Yu XJ, Su T, et al.: Urine macrophages reflect kidney macrophage content during acute tubular interstitial and glomerular injury. Clin Immunol 205: 6574, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 38

    Moledina DG, Luciano RL, Kukova L, Chan L, Saha A, Nadkarni G, et al.: Kidney biopsy-related complications in hospitalized patients with acute kidney disease. Clin J Am Soc Nephrol 13: 16331640, 2018 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 39

    Korbet SM, Gashti CN, Evans JK, Whittier WL: Risk of percutaneous renal biopsy of native kidneys in the evaluation of acute kidney injury. Clin Kidney J 11: 610615, 2018 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 40

    Isik B, Alexander MP, Manohar S, Vaughan L, Kottschade L, Markovic S, et al.: Biomarkers, clinical features, and rechallenge for immune checkpoint inhibitor renal immune-related adverse events. Kidney Int Rep 6: 10221031, 2021 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 41

    Graham F, Lord M, Froment D, Cardinal H, Bollée G: The use of gallium-67 scintigraphy in the diagnosis of acute interstitial nephritis. Clin Kidney J 9: 7681, 2016 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 42

    Moledina DG, Perazella MA: Treatment of drug-induced acute tubulointerstitial nephritis: the search for better evidence. Clin J Am Soc Nephrol 13: 17851787, 2018 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 43

    Prendecki M, Tanna A, Salama AD, Tam FW, Cairns T, Taube D, et al.: Long-term outcome in biopsy-proven acute interstitial nephritis treated with steroids. Clin Kidney J 10: 233239, 2017 PubMed

    • Search Google Scholar
    • Export Citation
  • 44

    Valluri A, Hetherington L, Mcquarrie E, Fleming S, Kipgen D, Geddes CC, et al.: Acute tubulointerstitial nephritis in Scotland. QJM 108: 527532, 2015 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 45

    Chowdry AM, Azad H, Mir I, Najar MS, Ashraf BM, Muzafar WM, et al.: Drug-induced acute interstitial nephritis: Prospective randomized trial comparing oral steroids and high-dose intravenous pulse steroid therapy in guiding the treatment of this condition. Saudi J Kidney Dis Transpl 29: 598607, 2018 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 46

    Fernandez-Juarez G, Perez JV, Caravaca-Fontán F, Quintana L, Shabaka A, Rodriguez E, et al.; Spanish Group for the Study of Glomerular Diseases (GLOSEN): Duration of treatment with corticosteroids and recovery of kidney function in acute interstitial nephritis. Clin J Am Soc Nephrol 13: 18511858, 2018 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 47

    Raza MN, Hadid M, Keen CE, Bingham C, Salmon AH: Acute tubulointerstitial nephritis, treatment with steroid and impact on renal outcomes. Nephrology (Carlton) 17: 748753, 2012 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 48

    Lin JS, Mamlouk O, Selamet U, Tchakarov A, Glass WF, Sheth RA, et al.: Infliximab for the treatment of patients with checkpoint inhibitor-associated acute tubular interstitial nephritis. OncoImmunology 10: 1877415, 2021 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 49

    Bhaumik SK, Kher V, Arora P, Rai PK, Singhal M, Gupta A, et al.: Evaluation of clinical and histological prognostic markers in drug-induced acute interstitial nephritis. Ren Fail 18: 97104, 1996 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 50

    Cam G, Kwetcheu AT, Vigneau C, Siohan P, Queffeulou G, Gatault P, et al.: Acute and chronic nephropathy induced by fluindione must be addressed. Nephrol Dial Transplant 27: 15541558, 2012 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 51

    Parkhie SM, Fine DM, Lucas GM, Atta MG: Characteristics of patients with HIV and biopsy-proven acute interstitial nephritis. Clin J Am Soc Nephrol 5: 798804, 2010 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 52

    Wendt R, Schliecker J, Beige J: Inflammatory leucocyte infiltrates are associated with recovery in biopsy-proven acute interstitial nephritis: A 20-year registry-based case series. Clin Kidney J 12: 814820, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 53

    González E, Gutiérrez E, Galeano C, Chevia C, de Sequera P, Bernis C, et al.; Grupo Madrileño De Nefritis Intersticiales: Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis. Kidney Int 73: 940946, 2008 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 54

    Yarlagadda SG, Perazella MA: Drug-induced crystal nephropathy: an update. Expert Opin Drug Saf 7: 147158, 2008 PubMed

  • 55

    Daudon M, Frochot V, Bazin D, Jungers P: Drug-induced kidney stones and crystalline nephropathy: Pathophysiology, prevention and treatment. Drugs 78: 163201, 2018 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 56

    Luciano RL, Perazella MA: Crystalline-induced kidney disease: A case for urine microscopy. Clin Kidney J 8: 131136, 2015 PubMed

  • 57

    Herlitz LC, D’Agati VD, Markowitz GS: Crystalline nephropathies. Arch Pathol Lab Med 136: 713720, 2012 PubMed

  • 58

    Aggarwal KP, Narula S, Kakkar M, Tandon C: Nephrolithiasis: molecular mechanism of renal stone formation and the critical role played by modulators. BioMed Res Int 2013: 292953, 2013 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 59

    Mulay SR, Shi C, Ma X, Anders HJ: Novel insights into crystal-induced kidney injury. Kidney Dis 4: 4957, 2018 PubMed

  • 60

    Mulay SR, Evan A, Anders H-J: Molecular mechanisms of crystal-related kidney inflammation and injury: implications for cholesterol embolism, crystalline nephropathies and kidney stone disease. Nephrol Dial Transplant 29: 507514, 2014 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 61

    Knauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, David RJ, et al.: NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney Int 84: 895901, 2013 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 62

    Liu H, Ye T, Yang X, Liu J, Jiang K, Lu H, et al.: H19 promote calcium oxalate nephrocalcinosis-induced renal tubular epithelial cell injury via a ceRNA pathway. EBioMedicine 50: 366378, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 63

    Ludwig-Portugall I, Bartok E, Dhana E, Evers BD, Primiano MJ, Hall JP, et al.: An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice. Kidney Int 90: 525539, 2016 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 64

    Martin-Higueras C, Ludwig-Portugall I, Hoppe B, Kurts C: Targeting kidney inflammation as a new therapy for primary hyperoxaluria? Nephrol Dial Transplant 34: 908914, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 65

    Perazella MA: Pharmacology behind common drug nephrotoxicities. Clin J Am Soc Nephrol 13: 18971908, 2018 PubMed

  • 66

    Perazella MA: Drug-induced acute kidney injury: diverse mechanisms of tubular injury. Curr Opin Crit Care 25: 550557, 2019 PubMed

  • 67

    Cavanaugh C, Perazella MA: Urine sediment examination in the diagnosis and management of kidney disease: Core curriculum 2019. Am J Kidney Dis 73: 258272, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 68

    Perazella MA, Moeckel GW: Nephrotoxicity from chemotherapeutic agents: Clinical manifestations, pathobiology, and prevention/therapy. Semin Nephrol 30: 570581, 2010 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 69

    Green MR, Chamberlain MC: Renal dysfunction during and after high-dose methotrexate. Cancer Chemother Pharmacol 63: 599604, 2009 PubMed

  • 70

    Garneau AP, Riopel J, Isenring P: Acute methotrexate-induced crystal nephropathy. N Engl J Med 373: 26912693, 2015 26716929 PubMed

  • 71

    Nicholas Cossey L, Dvanajscak Z, Larsen CP: A diagnostician’s field guide to crystalline nephropathies. Semin Diagn Pathol 37: 135142, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 72

    Medrano C, Oberic L, Puisset F, Recher C, Larrieu-Ciron D, Ysebaert L, et al.: Life-threatening complications after high-dose methotrexate and the benefits of glucarpidase as salvage therapy: a cohort study of 468 patients. Leuk Lymphoma 62: 846853, 2021 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 73

    Slade H, Mulroy E, Ussher J, Putt T, Schollum J, Walker R: Sulfadiazine-induced crystal nephropathy: a new ‘old’ problem. Nephrology (Carlton) 20: 511, 2015 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 74

    Simon DI, Brosius FC 3rd, Rothstein DM: Sulfadiazine crystalluria revisited. The treatment of toxoplasma encephalitis in patients with acquired immunodeficiency syndrome. Arch Intern Med 150: 23792384, 1990 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 75

    Reilly RF, Tray K, Perazella MA: Indinavir nephropathy revisited: a pattern of insidious renal failure with identifiable risk factors. Am J Kidney Dis 38: E23, 2001 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 76

    Kopp JB, Miller KD, Mican JA, Feuerstein IM, Vaughan E, Baker C, et al.: Crystalluria and urinary tract abnormalities associated with indinavir. Ann Intern Med 127: 119125, 1997 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 77

    Soto K, Campos P, Manso R, Antunes AMM, Morello J, Perazella MA: Severe acute kidney injury and double tubulopathy due to dual toxicity caused by combination antiretroviral therapy. Kidney Int Rep 4: 494499, 2018 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 78

    Sury K, Perazella MA: The changing face of human immunodeficiency virus-mediated kidney disease. Adv Chronic Kidney Dis 26: 185197, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 79

    Hara M, Suganuma A, Yanagisawa N, Imamura A, Hishima T, Ando M: Atazanavir nephrotoxicity. Clin Kidney J 8: 137142, 2015 PubMed

  • 80

    Santoriello D, Al-Nabulsi M, Reddy A, Salamera J, D’Agati VD, Markowitz GS: Atazanavir-associated crystalline nephropathy. Am J Kidney Dis 70: 576580, 2017 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 81

    Nishijima T, Tsuchiya K, Tanaka N, Joya A, Hamada Y, Mizushima D, et al.: Single-nucleotide polymorphisms in the UDP-glucuronosyltransferase 1A-3′ untranslated region are associated with atazanavir-induced nephrolithiasis in patients with HIV-1 infection: A pharmacogenetic study. J Antimicrob Chemother 69: 33203328, 2014 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 82

    Hogan JJ, Alexander MP, Leung N: Dysproteinemia and the kidney: Core curriculum 2019. Am J Kidney Dis 74: 822836, 2019 PubMed

  • 83

    Rosner MH, Jhaveri KD, McMahon BA, Perazella MA: Onconephrology: The intersections between the kidney and cancer. CA Cancer J Clin 71: 4777, 2021 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 84

    Zuo C, Zhu Y, Xu G: An update to the pathogenesis for monoclonal gammopathy of renal significance. Ann Hematol 99: 703714, 2020 PubMed

  • 85

    Hutchison CA, Xiong F, Mollee P: The treatment of paraprotein-related kidney disease. Curr Opin Nephrol Hypertens 26: 477483, 2017 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 86

    Perazella MA, Finkel KW; American Society of Nephrology Onco-Nephology Forum: Paraprotein-related kidney disease: Attack of the killer M proteins. Clin J Am Soc Nephrol 11: 22562259, 2016 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 87

    Matsumura H, Furukawa Y, Nakagaki T, Furutani C, Osanai S, Noguchi K, et al.: mMltiple myeloma-associated Ig light chain crystalline cast nephropathy. Kidney Int Rep 5: 15951602, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 88

    Lerner G, Moradi S, Cohen-Bucay A, Chen H, Sanchorawala V, Gordon CE, et al.: Coincidental crystalline light chain cast nephropathy, light chain proximal tubulopathy, and urine crystallopathy: A case report and review of the literature. Clin Nephrol 93: 203208, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 89

    Luciano RL, Castano E, Fogazzi GB, Perazella MA: Light chain crystalline kidney disease: Diagnostic urine microscopy as the “liquid kidney biopsy”. Clin Nephrol 82: 387391, 2014 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 90

    Gallan AJ, Khalighi MA: Lambda light chain crystalline cast nephropathy and proximal tubulopathy. Kidney Int Rep 1: 316320, 2016 PubMed

  • 91

    Lin J, Markowitz GS, Valeri AM, Kambham N, Sherman WH, Appel GB, et al.: Renal monoclonal immunoglobulin deposition disease: The disease spectrum. J Am Soc Nephrol 12: 14821492, 2001 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 92

    Messiaen T, Deret S, Mougenot B, Bridoux F, Dequiedt P, Dion JJ, et al.: Adult Fanconi syndrome secondary to light chain gammopathy: clinicopathologic heterogeneity and unusual features in 11 patients. Medicine (Baltimore) 79: 135154, 2000 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 93

    Jung M, Lee Y, Lee H, Moon KC: Clinicopathological characteristics of light chain proximal tubulopathy in Korean patients and the diagnostic usefulness of immunohistochemical staining for immunoglobulin light chain. BMC Nephrol 21: 146, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 94

    Herlitz LC, Roglieri J, Resta R, Bhagat G, Markowitz GS: Light chain proximal tubulopathy. Kidney Int 76: 792797, 2009 PubMed

  • 95

    Sirac C, Batuman V, Sanders PW: The proximal tubule toxicity of immunoglobulin light chains. Kidney Int Rep 6: 12251231, 2021 PubMed

  • 96

    Stokes MB, Valeri AM, Herlitz L, Khan AM, Siegel DS, Markowitz GS, et al.: Light chain proximal tubulopathy: Clinical and pathologic characteristics in the modern treatment era. J Am Soc Nephrol 27: 15551565, 2016 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 97

    Leboulleux M, Lelongt B, Mougenot B: Protease resistance and binding of Ig light changes in myeloma-associated tubulopathies. Kidney Int 48: 7279, 1995 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 98

    DeLyria PA, Avedschmidt SE, Yamada C, Farkash EA: Fatal cryocrystalglobulinemia with intravascular and renal tubular crystalline deposits. Am J Kidney Dis 67: 787791, 2016 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 99

    Gupta V, El Ters M, Kashani K, Leung N, Nasr SH: Crystalglobulin-induced nephropathy. J Am Soc Nephrol 26: 525529, 2015 PubMed

  • 100

    D’Costa MR, Dalvin LA, Manohar S, Maguire LJ, Grande JP, Gonsalves WI, et al.: Crystalglobulin-induced nephropathy and keratopathy. Kidney Med 1: 7174, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 101

    Gupta RK, Arend LJ, Bk A, Narsipur S, Bhargava R: Crystalglobulin-associated nephropathy presenting as MGRS in a case of monoclonal B-cell lymphocytosis: A case report. BMC Nephrol 21: 184, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 102

    Pichler Sekulic S, Negrea L, Pradhan N, Kalahasti P, Kansal S, Sekulic M: Concomitant monoclonal immunoglobulin deposition disease and crystalglobulin-induced nephropathy with a membranoproliferative pattern of glomerular injury. Clin Nephrol 94: 155160, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 103

    Nasr SH, D’Agati VD, Said SM, Stokes MB, Largoza MV, Radhakrishnan J, et al.: Oxalate nephropathy complicating Roux-en-Y gastric bypass: an underrecognized cause of irreversible renal failure. Clin J Am Soc Nephrol 3: 16761683, 2008 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 104

    Sinha MK, Collazo-Clavell ML, Rule A, Milliner DS, Nelson W, Sarr MG, et al.: Hyperoxaluric nephrolithiasis is a complication of Roux-en-Y gastric bypass surgery. Kidney Int 72: 100107, 2007 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 105

    Cartery C, Faguer S, Karras A, Cointault O, Buscail L, Modesto A, et al.: Oxalate nephropathy associated with chronic pancreatitis. Clin J Am Soc Nephrol 6: 18951902, 2011 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 106

    Sunkara V, Pelkowski TD, Dreyfus D, Satoskar A: Acute kidney disease due to excessive vitamin C ingestion and remote Roux-en-Y gastric bypass surgery superimposed on CKD. Am J Kidney Dis 66: 721724, 2015 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 107

    Singh A, Sarkar SR, Gaber LW, Perazella MA: Acute oxalate nephropathy associated with orlistat, a gastrointestinal lipase inhibitor. Am J Kidney Dis 49: 153157, 2007 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 108

    Cossey LN, Rahim F, Larsen CP: Oxalate nephropathy and intravenous vitamin C. Am J Kidney Dis 61: 10321035, 2013 PubMed

  • 109

    Getting JE, Gregoire JR, Phul A, Kasten MJ: Oxalate nephropathy due to ‘juicing’: Case report and review. Am J Med 126: 768772, 2013 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 110

    Makkapati S, D’Agati VD, Balsam L: “Green smoothie cleanse” causing acute oxalate nephropathy. Am J Kidney Dis 71: 281286, 2018 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 111

    Hanouneh M, Chen TK: Calcium oxalate crystals in ethylene glycol toxicity. N Engl J Med 377: 1467, 2017 PubMed

  • 112

    Strauss SB, Waltuch T, Bivin W, Kaskel F, Levin TL: Primary hyperoxaluria: Spectrum of clinical and imaging findings. Pediatr Radiol 47: 96103, 2017 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 113

    Lingeman JE, Pareek G, Easter L, Pease R, Grujic D, Brettman L, et al.: ALLN-177, oral enzyme therapy for hyperoxaluria. Int Urol Nephrol 51: 601608, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 114

    Pfau A, Grujic D, Keddis MT, Kausz AT, Lieske JC, Knauf F: Pilot study of reloxaliase in patients with severe enteric hyperoxaluria and hyperoxalemia. Nephrol Dial Transplant 36: 945948, 2021 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 115

    Scott LJ, Keam SJ: Lumasiran: First approval. Drugs 81: 277282, 2021 PubMed

  • 116

    Liebow A, Li X, Racie T, Hettinger J, Bettencourt BR, Najafian N, et al.: An investigational RNAi therapeutic targeting glycolate oxidase reduces oxalate production in models of primary hyperoxaluria. J Am Soc Nephrol 28: 494503, 2017 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 117

    Garrelfs SF, Frishberg Y, Hulton SA, Koren MJ, O’Riordan WD, Cochat P, et al.; ILLUMINATE-A Collaborators: Lumasiran, an RNAi therapeutic for primary hyperoxaluria type 1. N Engl J Med 384: 12161226, 2021 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 118

    Letavernier E, Daudon M: Stiripentol identifies a therapeutic target to reduce oxaluria. Curr Opin Nephrol Hypertens 29: 394399, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 119

    Wyatt CM, Drüeke TB: Stiripentol for the treatment of primary hyperoxaluria and calcium oxalate nephropathy. Kidney Int 97: 1719, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 120

    Le Dudal M, Huguet L, Perez J, Vandermeersch S, Bouderlique E, Tang E, et al.: Stiripentol protects against calcium oxalate nephrolithiasis and ethylene glycol poisoning. J Clin Invest 129: 25712577, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 121

    Kempf C, Pfau A, Holle J, Müller-Schlüter K, Bufler P, Knauf F, et al.: Stiripentol fails to lower plasma oxalate in a dialysis-dependent PH1 patient. Pediatr Nephrol 35: 17871789, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 122

    Zhu CY, Sturgeon C, Yeh MW: Diagnosis and management of primary hyperparathyroidism. JAMA 323: 11861187, 2020 PubMed

  • 123

    Bergner R, Löffler C: Renal sarcoidosis: Approach to diagnosis and management. Curr Opin Pulm Med 24: 513520, 2018 PubMed

  • 124

    Beall DP, Henslee HB, Webb HR, Scofield RH: Milk-alkali syndrome: A historical review and description of the modern version of the syndrome. Am J Med Sci 331: 233242, 2006 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 125

    Bollerslev J, Pretorius M, Heck A: Parathyroid hormone independent hypercalcemia in adults. Best Pract Res Clin Endocrinol Metab 32: 621638, 2018 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 126

    Jacobs TP, Bilezikian JP: Clinical review: Rare causes of hypercalcemia. J Clin Endocrinol Metab 90: 63166322, 2005 PubMed

  • 127

    Peacock M: Phosphate metabolism in health and disease. Calcif Tissue Int 108: 315, 2021 PubMed

  • 128

    Matuszkiewicz-Rowinska J, Malyszko J: Prevention and treatment of tumor lysis syndrome in the era of onco-nephrology progress. Kidney Blood Press Res 45: 645660, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 129

    Bosch X, Poch E, Grau JM: Rhabdomyolysis and acute kidney injury. N Engl J Med 361: 6272, 2009 PubMed

  • 130

    Markowitz GS, Stokes MB, Radhakrishnan J, D’Agati VD: Acute phosphate nephropathy following oral sodium phosphate bowel purgative: An underrecognized cause of chronic renal failure. J Am Soc Nephrol 16: 33893396, 2005 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 131

    Markowitz GS, Perazella MA: Acute phosphate nephropathy. Kidney Int 76: 10271034, 2009 PubMed

  • 132

    van Berkel Y, Ludwig M, van Wijk JAE, Bökenkamp A: Proteinuria in Dent disease: A review of the literature. Pediatr Nephrol 32: 18511859, 2017 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 133

    Dickson FJ, Sayer JA: Nephrocalcinosis: a review of monogenic causes and insights they provide into this heterogeneous condition. Int J Mol Sci 21: 369, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 134

    Hoppe B, Martin-Higueras C: Inherited conditions resulting in nephrolithiasis. Curr Opin Pediatr 32: 273283, 2020 PubMed

  • 135

    Ejaz AA, Johnson RJ, Shimada M, Mohandas R, Alquadan KF, Beaver TM, et al.: The role of uric acid in acute kidney injury. Nephron 142: 275283, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 136

    Tesser Poloni JA, Perazella MA: A rarely recognized cause of acute kidney injury in rhabdomyolysis. Am J Med Sci 356: e27, 2018 PubMed

  • 137

    Bardin T, Nguyen QD, Tran KM, Le NH, Do MD, Richette P, et al.: A cross-sectional study of 502 patients found a diffuse hyperechoic kidney medulla pattern in patients with severe gout. Kidney Int 99: 218226, 2021 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 138

    Johnson RJ, Nakagawa T, Jalal D, Sánchez-Lozada LG, Kang DH, Ritz E: Uric acid and chronic kidney disease: Which is chasing which? Nephrol Dial Transplant 28: 22212228, 2013 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 139

    Sellmayr M, Hernandez Petzsche MR, Ma Q, Krüger N, Liapis H, Brink A, et al.: Only hyperuricemia with crystalluria, but not asymptomatic hyperuricemia, drives progression of chronic kidney disease. J Am Soc Nephrol 31: 27732792, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 140

    Sas DJ, Harris PC, Milliner DS: Recent advances in the identification and management of inherited hyperoxalurias. Urolithiasis 47: 7989, 2019 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 141

    Belostotsky R, Frishberg Y: Novel therapeutic approaches for the primary hyperoxalurias. Pediatr Nephrol 36: 25932606, 2021 PubMed

  • 142

    Veys KR, Elmonem MA, Arcolino FO, van den Heuvel L, Levtchenko E: Nephropathic cystinosis: An update. Curr Opin Pediatr 29: 168178, 2017 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 143

    Emma F, Nesterova G, Langman C, Labbé A, Cherqui S, Goodyer P, et al.: Nephropathic cystinosis: An international consensus document. Nephrol Dial Transplant 29[Suppl 4]: iv87iv94, 2014 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 144

    Veys KRP, Elmonem MA, Van Dyck M, Janssen MC, Cornelissen EAM, Hohenfellner K, et al.: Chitotriosidase as a novel biomarker for therapeutic monitoring of nephropathic cystinosis. J Am Soc Nephrol 31: 10921106, 2020 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 145

    Rocca CJ, Cherqui S: Potential use of stem cells as a therapy for cystinosis. Pediatr Nephrol 34: 965973, 2019 PubMed

  • 146

    Edvardsson VO, Goldfarb DS, Lieske JC, Beara-Lasic L, Anglani F, Milliner DS, et al.: Hereditary causes of kidney stones and chronic kidney disease. Pediatr Nephrol 28: 19231942, 2013 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 147

    Nasr SH, Sethi S, Cornell LD, Milliner DS, Boelkins M, Broviac J, et al.: Crystalline nephropathy due to 2,8-dihydroxyadeninuria: An under-recognized cause of irreversible renal failure. Nephrol Dial Transplant 25: 19091915, 2010 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 148

    Cochran B, Kovačíková T, Hodaňová K, Živná M, Hnízda A, Niehaus AG, et al.: Chronic tubulointerstitial kidney disease in untreated adenine phosphoribosyl transferase (APRT) deficiency: A case report. Clin Nephrol 90: 296301, 2018 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 149

    Runolfsdottir HL, Palsson R, Agustsdottir IM, Indridason OS, Edvardsson VO: Kidney disease in adenine phosphoribosyltransferase deficiency. Am J Kidney Dis 67: 431438, 2016 PubMed

    • Crossref
    • Search Google Scholar
    • Export Citation

Metrics

All Time Past Year Past 30 Days
Abstract Views 217 217 151
Full Text Views 262 262 216
PDF Downloads 243 243 206