Home Hemodialysis
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  • 1 Nephrologist, Humber River Hospital, Toronto, Canada
  • | 2 Professor of Medicine, University of Toronto, Toronto, Canada
  • | 3 Nephrologist, AHEPA Hospital, Thessaloniki, Greece
  • | 4 Aristotle University of Thessaloniki, Thessaloniki, Greece
  • 1.

    Blagg CR: The early history of dialysis for chronic renal failure in the United States: a view from Seattle. Am J Kidney Dis 73(3): 32635 e1, 2021 10.1053/j.ajkd.2020.05.030 PubMed

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  • 2.

    Htay H, Bello AK, Levin A, Lunney M, Osman MA, Ye F, et al.: Hemodialysis use and practice patterns: An international survey study. Am J Kidney Dis 2021;77(3):326–35 e1.10.1053/j.ajkd.2020.05.030 PubMed

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  • 3.

    Abra G, Schiller B: Public policy and programs: Missing links in growing home dialysis in the United States. Semin Dial 33: 7582, 2020 10.1111/sdi.12850 PubMed

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  • 4.

    USRDS: USRDS annual data report 2020. 2020. Available at: https://adr.usrds.org/2020/end-stage-renal-disease. Accessed Nov 14, 2020

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    Shen JI, Chen L, Vangala S, Leng L, Shah A, Saxena AB, et al. :Socioeconomic factors and racial and ethnic differences in the initiation of home dialysis. Kidney Med 2: 105115, 2020 10.1016/j.xkme.2019.11.006

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  • 6.

    Ethier I, Cho Y, Hawley C, Pascoe EM, Roberts MA, Semple D, et al.: Effect of patient- and center-level characteristics on uptake of home dialysis in Australia and New Zealand: a multicenter registry analysis. Nephrol Dial Transplant 35: 19381949, 2020 10.1093/ndt/gfaa002 PubMed

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  • 7.

    van der Tol A, Stel VS, Jager KJ, Lameire N, Morton RL, Van Biesen W, et al.: A call for harmonization of European kidney care: Dialysis reimbursement and distribution of kidney replacement therapies. Nephrol Dial Transplant 35: 979986, 2020 10.1093/ndt/gfaa035 PubMed

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  • 8.

    Chan CT, Wallace E, Golper TA, Rosner MH, Seshasai RK, Glickman JD, et al.: Exploring barriers and potential solutions in home dialysis: An NKF-KDOQI conference outcomes report. Am J Kidney Dis 73: 363371, 2019 10.1053/j.ajkd.2018.09.015 PubMed

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  • 9.

    Chan CT, Collins K, Ditschman EP, Koester-Wiedemann L, Saffer TL, Wallace E, et al.: Overcoming barriers for uptake and continued use of home dialysis: An NKF-KDOQI conference report. Am J Kidney Dis 75: 926934, 2020 10.1053/j.ajkd.2019.11.007 PubMed

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  • 10.

    Walker RC, Morton RL, Palmer SC, Marshall MR, Tong A, Howard K: A discrete choice study of patient preferences for dialysis modalities. Clin J Am Soc Nephrol 13:100108 2018 10.2215/CJN.06830617

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  • 11.

    Diebel L, Jafari M, Shah S, Day C, McNaught C, Prasad B: Barriers to home hemodialysis across Saskatchewan, Canada: A cross-sectional survey of in-center dialysis patients. Can J Kidney Health Dis 7:2054358120948293, 2020 10.1177/2054358120948293

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  • 12.

    Kennedy C, Auguste BL, Girsberger M, Srithongkul T, Faratro R, Arustei D, et al.: The need for outpatient back-up for home hemodialysis patients: Implications for resource utilization. Hemodial Int 24: 454459, 2020 10.1111/hdi.12856 PubMed

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  • 13.

    Reintjes F, Herian N, Shah N, Pauly RP: Prospective monitoring of after-hours nursing and technologist support calls to a regional Canadian home hemodialysis program. Hemodial Int 23: 1925, 2019 10.1111/hdi.12677 PubMed

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  • 14.

    Auguste BL, Girsberger M, Kennedy C, Srithongkul T, McGrath-Chong M, Bargman J, et al.: Are adverse events in newly trained home dialysis patients related to learning styles? A single-centre retrospective study from Toronto, Canada. BMJ Open 10: e033315, 2020 10.1136/bmjopen-2019-033315

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  • 15.

    Chan CT, Blankestijn PJ, Dember LM, Gallieni M, Harris DCH, Lok CE, et al.; Conference Participants: Dialysis initiation, modality choice, access, and prescription: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int 96: 3747, 2019 10.1016/j.kint.2019.01.017 PubMed

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  • 16.

    Ibrahim A, Chan CT: Managing kidney failure with home hemodialysis. Clin J Am Soc Nephrol 14: 12681273, 2019 10.2215/CJN.13931118

  • 17.

    Lin E, Cheng XS, Chin KK, Zubair T, Chertow GM, Bendavid E, et al.: Home dialysis in the prospective payment system era. J Am Soc Nephrol 28: 29933004, 2017 10.1681/ASN.2017010041

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  • 18.

    Wilk AS, Hirth RA, Messana JM: Paying for frequent dialysis. Am J Kidney Dis 74: 248255, 2019 10.1053/j.ajkd.2019.01.027

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    Maddux FW, Ketchersid TL: The journey to full health care responsibility for one ESCO provider. Clin J Am Soc Nephrol 12: 20502052, 2017 10.2215/CJN.05520517

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  • 20.

    ESRD PPS Transitional Add-on Payment Adjustment for New and Innovative Equipment and Supplies (TPNIES) | CMS. Available at https://www.cms.gov/medicare/esrd-pps/esrd-pps-transitional-add-payment-adjustment-new-and-innovative-equipment-and-supplies-tpnies. Accessed March 25, 2021

  • 21.

    ESRD Treatment Choices (ETC) Model | CMS Innovation Center. Available at https://innovation.cms.gov/innovation-models/esrd-treatment-choices-model. Accessed March 25, 2021

  • 22.

    Reddy YNV, Tummalapalli SL, Mendu ML: Ensuring the equitable advancement of American kidney health-the need to account for socioeconomic disparities in the ESRD treatment choices model. J Am Soc Nephrol 32: 265267, 2021 10.1681/ASN.2020101466 PubMed

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  • 23.

    Patel S, Boehler A, Uehlecke N: A vision for advancing American kidney health: View from the US Department of Health and Human Services. Clin J Am Soc Nephrol 14: 17891791, 2019 10.2215/CJN.10460919

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  • 24.

    Bonventre JV, Hurst FP, West M, Wu I, Roy-Chaudhury P, Sheldon M: A technology roadmap for innovative approaches to kidney replacement therapies: A catalyst for change. Clin J Am Soc Nephrol 14: 15391547, 2019 10.2215/CJN.02570319

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  • 25.

    Manns B, Agar JWM, Biyani M, Blake PG, Cass A, Culleton B, et al.: Can economic incentives increase the use of home dialysis? Nephrol Dial Transplant 34: 731741, 2019 10.1093/ndt/gfy223 PubMed

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  • 26.

    Krahn MD, Bremner KE, de Oliveira C, Dixon SN, McFarlane P, Garg AX, et al.: Home dialysis is associated with lower costs and better survival than other modalities: A population-based study in Ontario, Canada. Perit Dial Int 39: 553561, 2019 10.3747/pdi.2018.00268 PubMed

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  • 27.

    Howell M, Walker RC, Howard K: Cost effectiveness of dialysis modalities: A Systematic Review of Economic Evaluations. Appl Health Econ Health Policy 17: 315330, 2019 10.1007/s40258-018-00455-2 PubMed

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  • 28.

    Wong CKH, Chen J, Fung SKS, Mok MMY, Cheng YL, Kong I, et al.: Direct and indirect costs of end-stage renal disease patients in the first and second years after initiation of nocturnal home haemodialysis, hospital haemodialysis and peritoneal dialysis. Nephrol Dial Transplant 34: 15651576, 2019 10.1093/ndt/gfy395 PubMed

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  • 29.

    Haroon S, Davenport A: Haemodialysis at home: Review of current dialysis machines. Expert Rev Med Devices 15: 337347, 2018 10.1080/17434440.2018.1465817 PubMed

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  • 30.

    Chertow GM, Alvarez L, Plumb TJ, Prichard SS, Aragon M: Patient-reported outcomes from the investigational device exemption study of the Tablo hemodialysis system. Hemodial Int 24: 480486, 2020 10.1111/hdi.12869

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  • 31.

    Komenda PVJ, Harper G, Wilson LM, Mitra S, Breen C, Milad JE: Hemodialysis with the Quanta SC+: Efficacy and safety of a self-care hemodialysis machine. Kidney Med 2: 724731e1, 2020 10.1016/j.xkme.2020.07.007

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  • 32.

    Leypoldt JK, Kraus MA, Collins AJ: Optimizing serum total carbon dioxide concentration during short and nocturnal frequent hemodialysis using lactate as dialysate buffer base. Hemodial Int 24: 470479, 2020 10.1111/hdi.12864 PubMed

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  • 33.

    Salani M, Roy S, Fissell WH 4th: Innovations in wearable and implantable artificial kidneys. Am J Kidney Dis 72: 745751, 2018 10.1053/j.ajkd.2018.06.005 PubMed

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  • 34.

    Glerup R, Svensson M, Jensen JD, Christensen JH: Staphylococcus aureus bacteremia risk in hemodialysis patients using the buttonhole cannulation technique: A prospective multicenter study. Kidney Med 1: 263670, 2019 10.1016/j.xkme.2019.07.007

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  • 35.

    Nesrallah GE, Cuerden M, Wong JH, Pierratos A: Staphylococcus aureus bacteremia and buttonhole cannulation: Long-term safety and efficacy of mupirocin prophylaxis. Clin J Am Soc Nephrol 5: 10471053, 2010 10.2215/CJN.00280110

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  • 36.

    Huang SS, MacRae J, Ross D, Imtiaz R, Hollingsworth B, Nesrallah GE, et al.: Buttonhole versus stepladder cannulation for home hemodialysis: A multicenter, randomized, pilot trial. Clin J Am Soc Nephrol; 14: 403410, 2019 10.2215/CJN.08310718

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  • 37.

    Lockridge R, Cornelis T, Van Eps C: Prescriptions for home hemodialysis. Hemodial Int 19[Suppl 1]: S112S127, 2015 10.1111/hdi.12279 PubMed

  • 38.

    Lockridge R, Weinhandl E, Kraus M, Schreiber M, Spry L, Tailor P, et al.: A systematic approach to promoting home hemodialysis during end stage kidney disease. Kidney360 1: 9931001, 2020 10.34067/kid.0003132020

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  • 39.

    Bowman B, Zheng S, Yang A, Schiller B, Morfín JA, Seek M, et al.: Improving incident ESRD care via a transitional care unit. Am J Kidney Dis 72: 278283, 2018 10.1053/j.ajkd.2018.01.035 PubMed

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  • 40.

    Attalla M, Friedman Z, McKeown S, Harel Z, Hingwala J, Molnar AO, et al.: Characteristics and effectiveness of dedicated care programs for patients starting dialysis: A systematic review. Kidney360 1: 12441253, 2020 10.34067/kid.0004052020

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  • 41.

    Morton RL, Sellars M: From patient-centered to person-centered care for kidney diseases. Clin J Am Soc Nephrol 14: 623625, 2019 10.2215/CJN.10380818

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  • 42.

    Wilkie M, Barnes T: Shared hemodialysis care: Increasing patient involvement in center-based dialysis. Clin J Am Soc Nephrol 14: 14021404, 2019 10.2215/CJN.02050219

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  • 43.

    Murea M, Kalantar-Zadeh K: Incremental and twice-weekly hemodialysis program in practice. Clin J Am Soc Nephrol 16: 147149, 2020 10.2215/CJN.04170320

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  • 44.

    Chazot C, Jean G: End-stage kidney patients require hemodialysis therapy full start. Blood Purif 47: 214222, 2019 10.1159/000494582 PubMed

  • 45.

    Walker RC, Tipene-Leach D, Graham A, Palmer SC: Patients' experiences of community house hemodialysis: A qualitative study. Kidney Med 1: 338346, 2019 1016/j.xkme.2019.07.010

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  • 46.

    Morita PP, Huynh K, Zakir A, Cafazzo JA, McQuillan RF, Bargman JM, et al.: Supporting the establishment of new home dialysis programs through the Explore Home Dialysis Program. Kidney Int Rep 4: 293300, 2019 10.1016/j.ekir.2018.10.019

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  • 47.

    Pierratos A, Tremblay M, Kandasamy G, Woodward G, Blake P, Graham J, et al.: Personal support worker (PSW)-supported home hemodialysis: A paradigm shift. Hemodial Int 21: 173179, 2017 10.1111/hdi.12476 PubMed

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  • 48.

    Lew SQ, Sikka N: Operationalizing telehealth for home dialysis patients in the United States. Am J Kidney Dis 74: 95100, 2019 10.1053/j.ajkd.2019.01.023 PubMed

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  • 49.

    Belcher JM: The role of telenephrology in the management of chronic kidney disease. Kidney360 1: 13101315, 2020 10.34067/KID.0000802019

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    Weinhandl ED, Collins AJ: Relative risk of home hemodialysis attrition in patients using a telehealth platform. Hemodial Int 22: 318327, 2018 10.1111/hdi.12621 PubMed

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  • 51.

    Liu N, Kim J, Jung Y, Arisy A, Nicdao MA, Mikaheal M, et al.: Remote monitoring systems for chronic patients on home hemodialysis: Field test of a copresence-enhanced design. JMIR Hum Factors 4: e21, 2017 10.2196/humanfactors.7078

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  • 52.

    Roumeliotis A, Roumeliotis S, Chan C, Pierratos A: Cardiovascular benefits of extended-time nocturnal hemodialysis. Curr Vasc Pharmacol 19: 2133, 2021 10.2174/1570161118666200401112106 PubMed

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  • 53.

    Cherukuri S, Bajo M, Colussi G, Corciulo R, Fessi H, Ficheux M, et al.: Home hemodialysis treatment and outcomes: retrospective analysis of the Knowledge to Improve Home Dialysis Network in Europe (KIHDNEy) cohort. BMC Nephrol 19: 262, 2018 10.1186/s12882-018-1059-2

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  • 54.

    Gangaram V, Vilpakka M, Goffin E, Weinhandl ED, Kubisiak KM, Borman N: Nocturnal home hemodialysis with low-flow dialysate: Retrospective analysis of the first European patients. Hemodial Int 24: 175181, 2020 10.1111/hdi.12808 PubMed

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  • 55.

    Girsberger M, Trinh E, Chan CT: Ventricular ejection fraction over time in patients on intensive home hemodialysis: A retrospective cohort study. Hemodial Int 24: 290298, 2020 10.1111/hdi.12838 PubMed

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  • 56.

    Chan CT, Kaysen GA, Beck GJ, Li M, Lo J, Rocco MV, et al.: Changes in biomarker profile and left ventricular hypertrophy regression: Results from the Frequent Hemodialysis Network Trials. Am J Nephrol 47: 208217, 2018 10.1159/000488003

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    Smyth B, Chan CT, Grieve SM, Puranik R, Zuo L, Hong D, et al.: Predictors of change in left-ventricular structure and function in a trial of extended hours hemodialysis. J Card Fail 26: 482491, 2020 10.1016/j.cardfail.2020.03.010 PubMed

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  • 58.

    Budhram B, Sinclair A, Komenda P, Severn M, Sood MM: A comparison of patient-reported outcome measures of quality of life by dialysis modality in the treatment of kidney failure: A systematic review. Can J Kidney Health Dis 7: 2054358120957431, 2020 10.1177/2054358120957431

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  • 59.

    Smyth B, van den Broek-Best O, Hong D, Howard K, Rogers K, Zuo L, et al.: Varying association of extended hours dialysis with quality of life. Clin J Am Soc Nephrol 14: 17511762, 2019 10.2215/CJN.06800619

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  • 60.

    Jansz TT, Bonenkamp AA, Boereboom FTJ, van Reekum FE, Verhaar MC, van Jaarsveld BC: Health-related quality of life compared between kidney transplantation and nocturnal hemodialysis. PLoS One 13: e0204405, 2018 10.1371/journal.pone.0204405

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    Garg AX, Suri RS, Eggers P, Finkelstein FO, Greene T, Kimmel PL, et al.: Patients receiving frequent hemodialysis have better health-related quality of life compared to patients receiving conventional hemodialysis. Kidney Int 91: 746754, 2017 10.1016/j.kint.2016.10.033

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    Rocco MV, Daugirdas JT, Greene T, Lockridge RS, Chan C, Pierratos A, et al.: Long-term effects of frequent nocturnal hemodialysis on mortality: The Frequent Hemodialysis Network (FHN) Nocturnal Trial. Am J Kidney Dis 66: 459468, 2015 10.1053/j.ajkd.2015.02.331

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  • 63.

    Pauly RP, Miller BW: Contextualizing the FHN nocturnal trial a decade later: How nocturnal home hemodialysis is performed matters to outcomes. Clin J Am Soc Nephrol ▪▪▪: CJN.09160620, 2020 10.2215/CJN.09160620 PubMed

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    Mathew A, McLeggon JA, Mehta N, Leung S, Barta V, McGinn T, et al.: Mortality and hospitalizations in intensive dialysis: A systematic review and meta-analysis. Can J Kidney Health Dis 5: 2054358117749531, 2018 10.1177/2054358117749531

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  • 65.

    Jansz TT, Noordzij M, Kramer A, Laruelle E, Couchoud C, Collart F, et al.: Survival of patients treated with extended-hours haemodialysis in Europe: An analysis of the ERA-EDTA Registry. Nephrol Dial Transplant 35: 488495, 2020 10.1093/ndt/gfz208

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    Rydell H, Ivarsson K, Almquist M, Segelmark M, Clyne N: Improved long-term survival with home hemodialysis compared with institutional hemodialysis and peritoneal dialysis: A matched cohort study. BMC Nephrol 20: 52, 2019 10.1186/s12882-019-1245-x

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    Rydell H, Ivarsson K, Almquist M, Clyne N, Segelmark M: Fewer hospitalizations and prolonged technique survival with home hemodialysis: A matched cohort study from the Swedish Renal Registry. BMC Nephrol 20: 480, 2019 1186/s12882-019-1644-z

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    Tennankore KK, Na Y, Wald R, Chan CT, Perl J: Short daily-, nocturnal- and conventional-home hemodialysis have similar patient and treatment survival. Kidney Int 93: 188194, 2018 10.1016/j.kint.2017.06.014 PubMed

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    Kansal SK, Morfin JA, Weinhandl ED: Survival and kidney transplant incidence on home versus in-center hemodialysis, following peritoneal dialysis technique failure. Perit Dial Int 39: 2534, 2019 10.3747/pdi.2017.00207 PubMed

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    Perl J, Na Y, Tennankore KK, Chan CT: Temporal trends and factors associated with home hemodialysis technique survival in Canada. Clin J Am Soc Nephrol 12: 12481258, 2017 10.2215/CJN.13271216

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    Pauly RP, Rosychuk RJ, Usman I, Reintjes F, Muneer M, Chan CT, et al.: Technique failure in a multicenter Canadian home hemodialysis cohort. Am J Kidney Dis 73: 230239, 2019 10.1053/j.ajkd.2018.08.016 PubMed

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    Shah N, Reintjes F, Courtney M, Klarenbach SW, Ye F, Schick-Makaroff K, et al.: Quality assurance audit of technique failure and 90-day mortality after program discharge in a Canadian home hemodialysis program. Clin J Am Soc Nephrol 12: 12591264, 2017 10.2215/CJN.00140117

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    Choi SJ, Obi Y, Ko GJ, You AS, Eriguchi R, Wang M, et al.: Comparing patient survival of home hemodialysis and peritoneal dialysis patients. Am J Nephrol 51: 192200, 2020 10.1159/000504691 PubMed

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    Nadeau-Fredette AC, Tennankore KK, Perl J, Bargman JM, Johnson DW, Chan CT: Home hemodialysis and peritoneal dialysis patient and technique survival in Canada. Kidney Int Rep; 5: 19651973, 2020 10.1016/j.ekir.2020.08.020

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    Trinh E, Hanley JA, Nadeau-Fredette AC, Perl J, Chan CT: A comparison of technique survival in Canadian peritoneal dialysis and home hemodialysis patients. Nephrol Dial Transplant; 34: 1941–1949, 2019 10.1093/ndt/gfz075

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    Pauly RP, Gill JS, Rose CL, Asad RA, Chery A, Pierratos A, et al.: Survival among nocturnal home haemodialysis patients compared to kidney transplant recipients. Nephrol Dial Transplant 24: 29152919, 2009 10.1093/ndt/gfp295 PubMed

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    Tennankore KK, Kim SJ, Baer HJ, Chan CT: Survival and hospitalization for intensive home hemodialysis compared with kidney transplantation. J Am Soc Nephrol 25: 21132120, 2014 10.1681/ASN.2013111180

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    Ethier I, Cho Y, Hawley C, Pascoe EM, Roberts MA, Semple D, et al.: Multicenter registry analysis comparing survival on home hemodialysis and kidney transplant recipients in Australia and New Zealand. Nephrol Dial Transplant ▪▪▪: gfaa159, 2020 10.1093/ndt/gfaa159 PubMed

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    Nishio-Lucar AG, Bose S, Lyons G, Awuah KT, Ma JZ, Lockridge RS, Jr. Intensive home hemodialysis survival comparable to deceased donor kidney transplantation. Kidney Int Rep 5: 296306, 2020 10.1016/j.ekir.2019.12.019

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    Vinson AJ, Perl J, Tennankore KK: Survival comparisons of home dialysis versus in-center hemodialysis: A narrative review. Can J Kidney Health Dis 6: 2054358119861941, 2019 10.1177/2054358119861941

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  • 81.

    Miller AJ, Perl J, Tennankore KK: Survival comparisons of intensive vs. conventional hemodialysis: Pitfalls and lessons. Hemodial Int 22: 922, 2018 10.1111/hdi.12559 PubMed

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