Calciphylaxis
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  • 1 Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
  • 1.

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    Nigwekar SU, Kroshinsky D, Nazarian RM, Goverman J, Malhotra R, Jackson VA, et al.: Calciphylaxis: risk factors, diagnosis, and treatment. Am J Kidney Dis 66: 133146, 2015 10.1053/j.ajkd.2015.01.034 PubMed

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    Polizzotto MN, Bryan T, Ashby MA, Martin P: Symptomatic management of calciphylaxis: a case series and review of the literature. J Pain Symptom Manage 32: 186190, 2006 10.1016/j.jpainsymman.2006.03.009 PubMed

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    Riemer CA, El-Azhary RA, Wu KL, Strand JJ, Lehman JS: Underreported use of palliative care and patient-reported outcome measures to address reduced quality of life in patients with calciphylaxis: a systematic review. Br J Dermatol 177: 15101518, 2017 10.1111/bjd.15702 PubMed

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    Dutta P, Chaudet KM, Nazarian RM, Kroshinsky D, Nigwekar SU: Correlation between clinical and pathological features of cutaneous calciphylaxis. PLoS One 14: e0218155, 2019 PubMed

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    Ghosh T, Winchester DS, Davis MDP, El-Azhary R, Comfere NI: Early clinical presentations and progression of calciphylaxis. Int J Dermatol 56: 856861, 2017 10.1111/ijd.13622 PubMed

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    Kramann R, Brandenburg VM, Schurgers LJ, Ketteler M, Westphal S, Leisten I, et al.: Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy. Nephrol Dial Transplant 28: 856868, 2013 10.1093/ndt/gfs466 PubMed

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    Weenig RH: Pathogenesis of calciphylaxis: Hans Selye to nuclear factor kappa-B. J Am Acad Dermatol 58: 458471, 2008 10.1016/j.jaad.2007.12.006 PubMed

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    Jeong HS, Dominguez AR: Calciphylaxis: Controversies in pathogenesis, diagnosis and treatment. Am J Med Sci 351: 217227, 2016 10.1016/j.amjms.2015.11.015 PubMed

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    Brandenburg VM, Kramann R, Rothe H, Kaesler N, Korbiel J, Specht P, et al.: Calcific uraemic arteriolopathy (calciphylaxis): Data from a large nationwide registry. Nephrol Dial Transplant 32: 126132, 2017 PubMed

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    Nigwekar SU, Zhao S, Wenger J, et al. A Nationally Representative Study of Calcific Uremic Arteriolopathy Risk Factors JASN 27: 3421–3429, 2016 DOI: ASN.2015091065 [pii]

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    McCarthy JT, El-Azhary RA, Patzelt MT, Weaver AL, Albright RC, Bridges AD, et al.: Survival, risk factors, and effect of treatment in 101 patients with calciphylaxis. Mayo Clin Proc 91: 13841394, 2016 10.1016/j.mayocp.2016.06.025 PubMed

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    Bajaj R, Courbebaisse M, Kroshinsky D, Thadhani RI, Nigwekar SU: Calciphylaxis in patients with normal renal function: A case series and systematic review. Mayo Clin Proc 93: 12021212, 2018 10.1016/j.mayocp.2018.06.001 PubMed

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    Nigwekar SU, Wolf M, Sterns RH, Hix JK: Calciphylaxis from nonuremic causes: A systematic review. Clin J Am Soc Nephrol 3: 11391143, 2008 10.2215/CJN.00530108 [doi] PubMed

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    Yu WY-H, Bhutani T, Kornik R, Pincus LB, Mauro T, Rosenblum MD, et al.: Warfarin-associated nonuremic calciphylaxis. JAMA Dermatol 153: 309314, 2017 PubMed

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    Nigwekar SU, Solid CA, Ankers E, Malhotra R, Eggert W, Turchin A, et al.: Quantifying a rare disease in administrative data: The example of calciphylaxis. J Gen Intern Med 29[Suppl 3]: S724S731, 2014 10.1007/s11606-014-2910-1 PubMed

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    Sowers KM, Hayden MR: Calcific uremic arteriolopathy: Pathophysiology, reactive oxygen species and therapeutic approaches. Oxid Med Cell Longev 3: 109121, 2010 10.4161/oxim.3.2.11354 PubMed

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    Nigwekar SU, Bhan I, Turchin A, Skentzos SC, Hajhosseiny R, Steele D, et al.: Statin use and calcific uremic arteriolopathy: A matched case-control study. Am J Nephrol 37: 325332, 2013 10.1159/000348806 PubMed

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    Nigwekar SU, Nazarian RM: Cutaneous calcification in patients with kidney disease is not always calciphylaxis. Kidney Int 94: 244246, 2018 10.1016/j.kint.2018.04.019 PubMed

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    Hayashi M: Calciphylaxis: diagnosis and clinical features. Clin Exp Nephrol 17: 498503, 2013 10.1007/s10157-013-0782-z PubMed

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    Zhang Y, Corapi KM, Luongo M, Thadhani R, Nigwekar SU: Calciphylaxis in peritoneal dialysis patients: A single center cohort study. Int J Nephrol Renovasc Dis 9: 235241, 2016 10.2147/IJNRD.S115701 PubMed

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    Ahmed S, O’Neill KD, Hood AF, Evan AP, Moe SM: Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells. Am J Kidney Dis 37: 12671276, 2001 10.1053/ajkd.2001.24533 PubMed

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    Gaisne R, Péré M, Menoyo V, Hourmant M, Larmet-Burgeot D: Calciphylaxis epidemiology, risk factors, treatment and survival among French chronic kidney disease patients: A case-control study. BMC Nephrol 21: 63, 2020 10.1186/s12882-020-01722-y PubMed

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    Centers for Disease Control and Prevention: (https://nccd.cdc.gov/CKD).

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    Gabel C, Chakrala T, Shah R, Danesh MJ, Dobry AS, Garza-Mayers AC, et al.: Penile calciphylaxis: A retrospective case-control study. [published online ahead of print May 15, 2020] J Am Acad Dermatol 10.1016/j.jaad.2020.05.042 PubMed

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    Moe SM, Chen NX: Calciphylaxis and vascular calcification: A continuum of extra-skeletal osteogenesis. Pediatr Nephrol 18: 969975, 2003 10.1007/s00467-003-1276-0 PubMed

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    Tan RYP, Juneja R, Gunawardane DN, Milton CA: Isolated mesenteric calciphylaxis with ischemic colitis in a hemodialysis patient without active cutaneous calciphylaxis: A case report of calcific uremic arteriolopathy. Kidney Med 2: 209212, 2020 10.1016/j.xkme.2019.12.005 PubMed

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    Nigwekar SU: Calciphylaxis. Curr Opin Nephrol Hypertens 26: 276281, 2017 10.1097/MNH.0000000000000328 PubMed

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    Aouizerate J, Valleyrie-Allanore L, Limal N, Ayache SS, Gherardi RK, Audard V, et al.: Ischemic myopathy revealing systemic calciphylaxis. Muscle Nerve 56: 529533, 2017 10.1002/mus.25505 PubMed

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    Farooqui S, Chan A, Cullen JF, Milea D: Too young to undergo temporal artery biopsy? Calciphylaxis-related anterior ischemic optic neuropathy. Neuroophthalmology 43: 252255, 2018 10.1080/01658107.2018.1493739 PubMed

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    Dominguez AR: New debates surrounding the histopathological findings of calciphylaxis: Do these give us new insights into pathogenesis of the disease? JAMA Dermatol 155: 773775, 2019 10.1001/jamadermatol.2019.0051 PubMed

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  • 42.

    Nigwekar SU, Bloch DB, Nazarian RM, Vermeer C, Booth SL, Xu D, et al.: Vitamin K-dependent carboxylation of matrix gla protein influences the risk of calciphylaxis. J Am Soc Nephrol 28: 17171722, 2017 10.1681/ASN.2016060651 [doi] PubMed

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    Nigwekar SU, Thadhani R: Long-term anticoagulation for patients receiving dialysis. Circulation 138: 15301533, 2018 10.1161/CIRCULATIONAHA.118.037091 PubMed

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    Cozzolino M, Mangano M, Galassi A, Ciceri P, Messa P, Nigwekar S: Vitamin K in chronic kidney disease. Nutrients 11: E168, 2019 10.3390/nu11010168 PubMed

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    Portales-Castillo I, Kroshinsky D, Malhotra CK, Culber-Costley R, Cozzolino MG, Karparis S, et al.: Calciphylaxis as a drug induced adverse event. Expert Opin Drug Saf 18: 2935, 2019 10.1080/14740338.2019.1559813 PubMed

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    Galloway PA, El-Damanawi R, Bardsley V, Pritchard NR, Fry AC, Ojha SK, et al.: Vitamin K antagonists predispose to calciphylaxis in patients with end-stage renal disease. Nephron 129: 197201, 2015 10.1159/000371449 [doi] PubMed

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    Nigwekar SU, Jiramongkolchai P, Wunderer F, Bloch E, Ichinose R, Nazarian RM, et al.: Increased bone morphogenetic protein signaling in the cutaneous vasculature of patients with calciphylaxis. Am J Nephrol 46: 429438, 2017 10.1159/000484418 PubMed

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    Mochel MC, Arakaki RY, Wang G, Kroshinsky D, Hoang MP: Cutaneous calciphylaxis: A retrospective histopathologic evaluation. Am J Dermatopathol 35: 582586, 2013 10.1097/DAD.0b013e31827c7f5d PubMed

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    Dobry AS, Ko LN, St John J, Sloan JM, Nigwekar S, Kroshinsky D: Association between hypercoagulable conditions and calciphylaxis in patients with renal disease: A case-control study. JAMA Dermatol 154: 182187, 2018 PubMed

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