Dysproteinemias
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  • 1 Division of Nephrology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
  • 2 Division of Nephrology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
  • 1.

    Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D’Agati VD, : The evaluation of monoclonal gammopathy of renal significance: A consensus report of the International Kidney and Monoclonal Gammopathy Research Group. Nat Rev Nephrol 15: 4559, 2019 PubMed

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  • 2.

    Paueksakon P, Revelo MP, Horn RG, Shappell S, Fogo AB: Monoclonal gammopathy: significance and possible causality in renal disease. Am J Kidney Dis 42: 8795, 2003 PubMed

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  • 3.

    Hogan JJ, Weiss BM: Bridging the divide: An onco-nephrologic approach to the monoclonal gammopathies of renal significance. Clin J Am Soc Nephrol 11: 16811691, 2016 PubMed

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  • 4.

    Bouchet A, Teuma C, Nouvier M, Rousset P, Javaugue V, Lazareth A, : Acute renal colic due to immunoglobulin free light chain kidney stones: A case report of an unusual complication of multiple myeloma. Am J Kidney Dis 74: 700702, 2019 PubMed

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  • 5.

    Fonseka CL, Galappaththi SR, Karunarathna JD, Abeyaratne DD, Tissera N: A case of multiple myeloma presenting as a distal renal tubular acidosis with extensive bilateral nephrolithiasis. BMC Hematol 16: 8, 2016 PubMed

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  • 6.

    Haas M, Spargo BH, Wit EJ, Meehan SM: Etiologies and outcome of acute renal insufficiency in older adults: A renal biopsy study of 259 cases. Am J Kidney Dis 35: 433447, 2000 PubMed

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  • 7.

    Herrera GA, Joseph L, Gu X, Hough A, Barlogie B: Renal pathologic spectrum in an autopsy series of patients with plasma cell dyscrasia. Arch Pathol Lab Med 128: 875879, 2004 PubMed

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  • 8.

    Korbet SM, Schwartz MM: Multiple myeloma. J Am Soc Nephrol 17: 25332545, 2006 PubMed

  • 9.

    Leung N, Gertz M, Kyle RA, Fervenza FC, Irazabal MV, Eirin A, : Urinary albumin excretion patterns of patients with cast nephropathy and other monoclonal gammopathy-related kidney diseases. Clin J Am Soc Nephrol 7: 19641968, 2012 PubMed

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  • 10.

    Said SM, Cosio FG, Valeri AM, Leung N, Sethi S, Salameh H, : Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits is associated with high rate of early recurrence in the allograft. Kidney Int 94: 159169, 2018 PubMed

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  • 11.

    Royal V, Leung N, Troyanov S, Nasr SH, Écotière L, LeBlanc R, : Clinicopathologic predictors of renal outcomes in light chain cast nephropathy: A multicenter retrospective study. Blood 135: 18331846, 2020 PubMed

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  • 12.

    Hutchison CA, Cockwell P, Stringer S, Bradwell A, Cook M, Gertz MA, : Early reduction of serum-free light chains associates with renal recovery in myeloma kidney. J Am Soc Nephrol 22: 11291136, 2011 PubMed

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  • 13.

    Bridoux F, Carron PL, Pegourie B, Alamartine E, Augeul-Meunier K, Karras A, ; MYRE Study Group: Effect of high-cutoff hemodialysis vs conventional hemodialysis on hemodialysis independence among patients with myeloma cast nephropathy: A randomized clinical trial. JAMA 318: 20992110, 2017 PubMed

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  • 14.

    Hutchison CA, Cockwell P, Moroz V, Bradwell AR, Fifer L, Gillmore JD, : High cutoff versus high-flux haemodialysis for myeloma cast nephropathy in patients receiving bortezomib-based chemotherapy (EuLITE): A phase 2 randomised controlled trial. Lancet Haematol 6: e217e228, 2019 PubMed

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  • 15.

    Gakhar B, Kobrin S, Berns JS: Extracorporeal treatment of cast nephropathy. Semin Dial 24: 911, 2011 PubMed

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    Zucchelli P, Pasquali S, Cagnoli L, Ferrari G: Controlled plasma exchange trial in acute renal failure due to multiple myeloma. Kidney Int 33: 11751180, 1988 PubMed

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  • 17.

    Johnson WJ, Kyle RA, Pineda AA, O’Brien PC, Holley KE: Treatment of renal failure associated with multiple myeloma: Plasmapheresis, hemodialysis, and chemotherapy. Arch Intern Med 150: 863869, 1990 PubMed

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  • 18.

    Clark WF, Stewart AK, Rock GA, Sternbach M, Sutton DM, Barrett BJ, ; Canadian Apheresis Group: Plasma exchange when myeloma presents as acute renal failure: A randomized, controlled trial. Ann Intern Med 143: 777784, 2005 PubMed

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  • 19.

    Leung N, Gertz MA, Zeldenrust SR, Rajkumar SV, Dispenzieri A, Fervenza FC, : Improvement of cast nephropathy with plasma exchange depends on the diagnosis and on reduction of serum free light chains. Kidney Int 73: 12821288, 2008 PubMed

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  • 20.

    Hogan JJ, Alexander MP, Leung N: Dysproteinemia and the kidney: Core curriculum 2019. Am J Kidney Dis 74: 822836, 2019 PubMed

  • 21.

    Merlini G, Stone MJ: Dangerous small B-cell clones. Blood 108: 25202530, 2006 PubMed

  • 22.

    Ryšavá R: AL amyloidosis: Advances in diagnostics and treatment. Nephrol Dial Transplant 34: 14601466, 2019 PubMed

  • 23.

    Barrett CD, Dobos K, Liedtke M, Tuzovic M, Haddad F, Kobayashi Y, : A changing landscape of mortality for systemic light chain amyloidosis. JACC Heart Fail 7: 958966, 2019 PubMed

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  • 24.

    Comenzo RL, Reece D, Palladini G, Seldin D, Sanchorawala V, Landau H, : Consensus guidelines for the conduct and reporting of clinical trials in systemic light-chain amyloidosis. Leukemia 26: 23172325, 2012 PubMed

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  • 25.

    Leung N, Glavey SV, Kumar S, Dispenzieri A, Buadi FK, Dingli D, : A detailed evaluation of the current renal response criteria in AL amyloidosis: Is it time for a revision? Haematologica 98: 988992, 2013 PubMed

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  • 26.

    D’Souza A, Dispenzieri A, Wirk B, Zhang MJ, Huang J, Gertz MA, : Improved outcomes after autologous hematopoietic cell transplantation for light chain amyloidosis: A Center for International Blood and Marrow Transplant Research Study. J Clin Oncol 33: 37413749, 2015 PubMed

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  • 27.

    Sanchorawala V, Sun F, Quillen K, Sloan JM, Berk JL, Seldin DC: Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem cell transplantation: 20-year experience. Blood 126: 23452347, 2015 PubMed

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  • 28.

    Sidiqi MH, Aljama MA, Buadi FK, Warsame RM, Lacy MQ, Dispenzieri A, : Stem cell transplantation for light chain amyloidosis: Decreased early mortality over time. J Clin Oncol 36: 13231329, 2018 PubMed

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  • 29.

    Sharpley FA, Petrie A, Mahmood S, Sachchithanantham S, Lachmann HJ, Gillmore JD, : A 24-year experience of autologous stem cell transplantation for light chain amyloidosis patients in the United Kingdom. Br J Haematol 187: 642652, 2019 PubMed

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  • 30.

    Milani P, Fazio F, Basset M, Berno T, Larocca A, Foli A, : High rate of profound clonal and renal responses with daratumumab treatment in heavily pre-treated patients with light chain (AL) amyloidosis and high bone marrow plasma cell infiltrate. Am J Hematol 95: 900905, 2020 PubMed

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  • 31.

    Angel-Korman A, Stern L, Sarosiek S, Sloan JM, Doros G, Sanchorawala V, : Long-term outcome of kidney transplantation in AL amyloidosis. Kidney Int 95: 405411, 2019 PubMed

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  • 32.

    Joly F, Cohen C, Javaugue V, Bender S, Belmouaz M, Arnulf B, : Randall-type monoclonal immunoglobulin deposition disease: Novel insights from a nationwide cohort study. Blood 133: 576587, 2019 PubMed

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  • 33.

    Hogan JJ, Markowitz GS: New insights into the pathogenesis and treatment of heavy chain deposition disease. Kidney Int 91: 272274, 2017 PubMed

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  • 34.

    Bridoux F, Javaugue V, Bender S, Leroy F, Aucouturier P, Debiais-Delpech C, : Unravelling the immunopathological mechanisms of heavy chain deposition disease with implications for clinical management. Kidney Int 91: 423434, 2017 PubMed

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  • 35.

    Bonaud A, Bender S, Touchard G, Lacombe C, Srour N, Delpy L, : A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy. Blood 126: 757765, 2015 PubMed

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  • 36.

    Zhang Y, Li X, Liang D, Xu F, Liang S, Zhu X, : Heavy chain deposition disease: Clinicopathologic characteristics of a Chinese case series. Am J Kidney Dis 75: 736743, 2020 PubMed

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  • 37.

    Stokes MB, Valeri AM, Herlitz L, Khan AM, Siegel DS, Markowitz GS, : Light chain proximal tubulopathy: Clinical and pathologic characteristics in the modern treatment era. J Am Soc Nephrol 27: 15551565, 2016 PubMed

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  • 38.

    Angioi A, Amer H, Fervenza FC, Sethi S: Recurrent light chain proximal tubulopathy in a kidney allograft. Am J Kidney Dis 68: 483487, 2016 PubMed

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  • 39.

    Fogo AB, Lusco MA, Najafian B, Alpers CE: AJKD atlas of renal pathology: Light chain proximal tubulopathy. Am J Kidney Dis 67: e9e10, 2016 PubMed

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  • 40.

    Cheng M, Gu X, Turbat-Herrera EA, Herrera GA: Tubular injury and dendritic cell activation are integral components of light chain-associated acute tubulointerstitial nephritis. Arch Pathol Lab Med 143: 12121224, 2019 PubMed

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  • 41.

    Fogo AB, Lusco MA, Najafian B, Alpers CE: AJKD atlas of renal pathology: Immunotactoid glomerulopathy. Am J Kidney Dis 66: e29e30, 2015 PubMed

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  • 42.

    Karasawa K, Uchida K, Nakano T, Moriyama T, Nitta K: Successful treatment with rituximab of immunotactoid glomerulopathy exhibiting nephrotic syndrome. Clin Nephrol 90: 222226, 2018 PubMed

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  • 43.

    Ohashi A, Kumagai J, Nagahama K, Fujisawa H: Case of immunotactoid glomerulopathy showing high responsiveness to steroids therapy despite severe pathological features. BMJ Case Rep 12: e229751, 2019 PubMed

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  • 44.

    Kousios A, Duncan N, Charif R, Tam FWK, Levy J, Cook HT, : Autologous stem cell transplant for the treatment of type i crystal cryoglobulinemic glomerulonephritis caused by monoclonal gammopathy of renal significance (MGRS). Kidney Int Rep 4: 13421348, 2019 PubMed

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  • 45.

    Singh M, Jackson KJL, Wang JJ, Schofield P, Field MA, Koppstein D, .: Lymphoma driver mutations in the pathogenic evolution of an iconic human autoantibody. Cell 180: 878894, 2020 PubMed

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  • 46.

    Jadoul M, Berenguer MC, Doss W, Fabrizi F, Izopet J, Jha V, : Executive summary of the 2018 KDIGO Hepatitis C in CKD Guideline: Welcoming advances in evaluation and management. Kidney Int 94: 663673, 2018 PubMed

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  • 47.

    Nasr SH, Markowitz GS, Stokes MB, Seshan SV, Valderrama E, Appel GB, : Proliferative glomerulonephritis with monoclonal IgG deposits: A distinct entity mimicking immune-complex glomerulonephritis. Kidney Int 65: 8596, 2004 PubMed

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  • 48.

    Nasr SH, Satoskar A, Markowitz GS, Valeri AM, Appel GB, Stokes MB, : Proliferative glomerulonephritis with monoclonal IgG deposits. J Am Soc Nephrol 20: 20552064, 2009 PubMed

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  • 49.

    Bhutani G, Nasr SH, Said SM, Sethi S, Fervenza FC, Morice WG, : Hematologic characteristics of proliferative glomerulonephritides with nonorganized monoclonal immunoglobulin deposits. Mayo Clin Proc 90: 587596, 2015 PubMed

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  • 50.

    Fermand JP, Bridoux F, Kyle RA, Kastritis E, Weiss BM, Cook MA, ; International Kidney and Monoclonal Gammopathy Research Group: How I treat monoclonal gammopathy of renal significance (MGRS). Blood 122: 35833590, 2013 PubMed

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  • 51.

    Gumber R, Cohen JB, Palmer MB, Kobrin SM, Vogl DT, Wasserstein AG, : A clone-directed approach may improve diagnosis and treatment of proliferative glomerulonephritis with monoclonal immunoglobulin deposits. Kidney Int 94: 199205, 2018 PubMed

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  • 52.

    Kamal J, Khairallah P, Crew RJ, Ye X, Swanson SJ, Kudose S, : Clinicopathologic assessment of monoclonal immunoglobulin-associated renal disease in the kidney allograft: A retrospective study and review of the literature. Transplantation 104: 13411349, 2020 PubMed

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  • 53.

    Best Rocha A, Larsen CP: Membranous glomerulopathy with light chain-restricted deposits: A clinicopathological analysis of 28 cases. Kidney Int Rep 2: 11411148, 2017 PubMed

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  • 54.

    Larsen CP, Ambuzs JM, Bonsib SM, Boils CL, Cossey LN, Messias NC, : Membranous-like glomerulopathy with masked IgG kappa deposits. Kidney Int 86: 154161, 2014 PubMed

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  • 55.

    Larsen CP, Boils CL, Cossey LN, Sharma SG, Walker PD: Clinicopathologic features of membranous-like glomerulopathy with masked IgG kappa deposits. Kidney Int Rep 1: 299305, 2016 PubMed

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  • 56.

    Larsen CP, Sharma SG, Caza TN, Kenan DJ, Storey AJ, Edmondson RD, : Serum amyloid P deposition is a sensitive and specific feature of membranous-like glomerulopathy with masked IgG kappa deposits. Kidney Int 97: 602608, 2020 PubMed

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  • 57.

    Andeen NK, Yang HY, Dai DF, MacCoss MJ, Smith KD: DnaJ homolog subfamily B member 9 is a putative autoantigen in fibrillary GN. J Am Soc Nephrol 29: 231239, 2018 PubMed

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  • 58.

    Dasari S, Alexander MP, Vrana JA, Theis JD, Mills JR, Negron V, : DnaJ heat shock protein family B member 9 is a novel biomarker for fibrillary gn. J Am Soc Nephrol 29: 5156, 2018 PubMed

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  • 59.

    Said SM, Leung N, Alexander MP, Cornell LD, Fidler ME, Grande JP, : DNAJB9-positive monotypic fibrillary glomerulonephritis is not associated with monoclonal gammopathy in the vast majority of patients. Kidney Int 98: 498504, 2020 PubMed

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