Dysproteinemias
By:
Gaia Coppock Division of Nephrology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Search for other papers by Gaia Coppock in
Current site
Google Scholar
PubMed Close
and
Jonathan J. Hogan Division of Nephrology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Search for other papers by Jonathan J. Hogan in
Current site
Google Scholar
PubMed Close
Volume/Issue:
Volume 19: Issue 2
Published Online:
Oct 2020
Restricted access
Purchase Print On-Demand ASN Members Sign In Here
  • Collapse
  • Expand
Cover Nephrology Self-Assessment Program
Copyright:
© American Society of Nephrology 2020
Page Count:
11
Article Category:
Research Article
Print Publication Date:
01 Oct 2020
Published Online:
Oct 2020
  • 1.

    Leung N , Bridoux F , Batuman V , Chaidos A , Cockwell P , D’Agati VD , et al.: The evaluation of monoclonal gammopathy of renal significance: A consensus report of the International Kidney and Monoclonal Gammopathy Research Group. Nat Rev Nephrol 15: 45–59, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Paueksakon P , Revelo MP , Horn RG , Shappell S , Fogo AB : Monoclonal gammopathy: significance and possible causality in renal disease. Am J Kidney Dis 42: 87–95, 2003 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Hogan JJ , Weiss BM : Bridging the divide: An onco-nephrologic approach to the monoclonal gammopathies of renal significance. Clin J Am Soc Nephrol 11: 1681–1691, 2016 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Bouchet A , Teuma C , Nouvier M , Rousset P , Javaugue V , Lazareth A , et al.: Acute renal colic due to immunoglobulin free light chain kidney stones: A case report of an unusual complication of multiple myeloma. Am J Kidney Dis 74: 700–702, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Fonseka CL , Galappaththi SR , Karunarathna JD , Abeyaratne DD , Tissera N : A case of multiple myeloma presenting as a distal renal tubular acidosis with extensive bilateral nephrolithiasis. BMC Hematol 16: 8, 2016 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Haas M , Spargo BH , Wit EJ , Meehan SM : Etiologies and outcome of acute renal insufficiency in older adults: A renal biopsy study of 259 cases. Am J Kidney Dis 35: 433–447, 2000 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Herrera GA , Joseph L , Gu X , Hough A , Barlogie B : Renal pathologic spectrum in an autopsy series of patients with plasma cell dyscrasia. Arch Pathol Lab Med 128: 875–879, 2004 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Korbet SM , Schwartz MM : Multiple myeloma. J Am Soc Nephrol 17: 2533–2545, 2006 PubMed

  • 9.

    Leung N , Gertz M , Kyle RA , Fervenza FC , Irazabal MV , Eirin A , et al.: Urinary albumin excretion patterns of patients with cast nephropathy and other monoclonal gammopathy-related kidney diseases. Clin J Am Soc Nephrol 7: 1964–1968, 2012 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Said SM , Cosio FG , Valeri AM , Leung N , Sethi S , Salameh H , et al.: Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits is associated with high rate of early recurrence in the allograft. Kidney Int 94: 159–169, 2018 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Royal V , Leung N , Troyanov S , Nasr SH , Écotière L , LeBlanc R , et al.: Clinicopathologic predictors of renal outcomes in light chain cast nephropathy: A multicenter retrospective study. Blood 135: 1833–1846, 2020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Hutchison CA , Cockwell P , Stringer S , Bradwell A , Cook M , Gertz MA , et al.: Early reduction of serum-free light chains associates with renal recovery in myeloma kidney. J Am Soc Nephrol 22: 1129–1136, 2011 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Bridoux F , Carron PL , Pegourie B , Alamartine E , Augeul-Meunier K , Karras A , et al.; MYRE Study Group: Effect of high-cutoff hemodialysis vs conventional hemodialysis on hemodialysis independence among patients with myeloma cast nephropathy: A randomized clinical trial. JAMA 318: 2099–2110, 2017 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Hutchison CA , Cockwell P , Moroz V , Bradwell AR , Fifer L , Gillmore JD , et al.: High cutoff versus high-flux haemodialysis for myeloma cast nephropathy in patients receiving bortezomib-based chemotherapy (EuLITE): A phase 2 randomised controlled trial. Lancet Haematol 6: e217–e228, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Gakhar B , Kobrin S , Berns JS : Extracorporeal treatment of cast nephropathy. Semin Dial 24: 9–11, 2011 PubMed

  • 16.

    Zucchelli P , Pasquali S , Cagnoli L , Ferrari G : Controlled plasma exchange trial in acute renal failure due to multiple myeloma. Kidney Int 33: 1175–1180, 1988 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Johnson WJ , Kyle RA , Pineda AA , O’Brien PC , Holley KE : Treatment of renal failure associated with multiple myeloma: Plasmapheresis, hemodialysis, and chemotherapy. Arch Intern Med 150: 863–869, 1990 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Clark WF , Stewart AK , Rock GA , Sternbach M , Sutton DM , Barrett BJ , et al.; Canadian Apheresis Group: Plasma exchange when myeloma presents as acute renal failure: A randomized, controlled trial. Ann Intern Med 143: 777–784, 2005 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Leung N , Gertz MA , Zeldenrust SR , Rajkumar SV , Dispenzieri A , Fervenza FC , et al.: Improvement of cast nephropathy with plasma exchange depends on the diagnosis and on reduction of serum free light chains. Kidney Int 73: 1282–1288, 2008 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Hogan JJ , Alexander MP , Leung N : Dysproteinemia and the kidney: Core curriculum 2019. Am J Kidney Dis 74: 822–836, 2019 PubMed

  • 21.

    Merlini G , Stone MJ : Dangerous small B-cell clones. Blood 108: 2520–2530, 2006 PubMed

  • 22.

    Ryšavá R : AL amyloidosis: Advances in diagnostics and treatment. Nephrol Dial Transplant 34: 1460–1466, 2019 PubMed

  • 23.

    Barrett CD , Dobos K , Liedtke M , Tuzovic M , Haddad F , Kobayashi Y , et al.: A changing landscape of mortality for systemic light chain amyloidosis. JACC Heart Fail 7: 958–966, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24.

    Comenzo RL , Reece D , Palladini G , Seldin D , Sanchorawala V , Landau H , et al.: Consensus guidelines for the conduct and reporting of clinical trials in systemic light-chain amyloidosis. Leukemia 26: 2317–2325, 2012 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25.

    Leung N , Glavey SV , Kumar S , Dispenzieri A , Buadi FK , Dingli D , et al.: A detailed evaluation of the current renal response criteria in AL amyloidosis: Is it time for a revision? Haematologica 98: 988–992, 2013 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    D’Souza A , Dispenzieri A , Wirk B , Zhang MJ , Huang J , Gertz MA , et al.: Improved outcomes after autologous hematopoietic cell transplantation for light chain amyloidosis: A Center for International Blood and Marrow Transplant Research Study. J Clin Oncol 33: 3741–3749, 2015 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27.

    Sanchorawala V , Sun F , Quillen K , Sloan JM , Berk JL , Seldin DC : Long-term outcome of patients with AL amyloidosis treated with high-dose melphalan and stem cell transplantation: 20-year experience. Blood 126: 2345–2347, 2015 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28.

    Sidiqi MH , Aljama MA , Buadi FK , Warsame RM , Lacy MQ , Dispenzieri A , et al.: Stem cell transplantation for light chain amyloidosis: Decreased early mortality over time. J Clin Oncol 36: 1323–1329, 2018 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 29.

    Sharpley FA , Petrie A , Mahmood S , Sachchithanantham S , Lachmann HJ , Gillmore JD , et al.: A 24-year experience of autologous stem cell transplantation for light chain amyloidosis patients in the United Kingdom. Br J Haematol 187: 642–652, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 30.

    Milani P , Fazio F , Basset M , Berno T , Larocca A , Foli A , et al.: High rate of profound clonal and renal responses with daratumumab treatment in heavily pre-treated patients with light chain (AL) amyloidosis and high bone marrow plasma cell infiltrate. Am J Hematol 95: 900–905, 2020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31.

    Angel-Korman A , Stern L , Sarosiek S , Sloan JM , Doros G , Sanchorawala V , et al.: Long-term outcome of kidney transplantation in AL amyloidosis. Kidney Int 95: 405–411, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 32.

    Joly F , Cohen C , Javaugue V , Bender S , Belmouaz M , Arnulf B , et al.: Randall-type monoclonal immunoglobulin deposition disease: Novel insights from a nationwide cohort study. Blood 133: 576–587, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 33.

    Hogan JJ , Markowitz GS : New insights into the pathogenesis and treatment of heavy chain deposition disease. Kidney Int 91: 272–274, 2017 PubMed

  • 34.

    Bridoux F , Javaugue V , Bender S , Leroy F , Aucouturier P , Debiais-Delpech C , et al.: Unravelling the immunopathological mechanisms of heavy chain deposition disease with implications for clinical management. Kidney Int 91: 423–434, 2017 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35.

    Bonaud A , Bender S , Touchard G , Lacombe C , Srour N , Delpy L , et al.: A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy. Blood 126: 757–765, 2015 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 36.

    Zhang Y , Li X , Liang D , Xu F , Liang S , Zhu X , et al.: Heavy chain deposition disease: Clinicopathologic characteristics of a Chinese case series. Am J Kidney Dis 75: 736–743, 2020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 37.

    Stokes MB , Valeri AM , Herlitz L , Khan AM , Siegel DS , Markowitz GS , et al.: Light chain proximal tubulopathy: Clinical and pathologic characteristics in the modern treatment era. J Am Soc Nephrol 27: 1555–1565, 2016 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 38.

    Angioi A , Amer H , Fervenza FC , Sethi S : Recurrent light chain proximal tubulopathy in a kidney allograft. Am J Kidney Dis 68: 483–487, 2016 PubMed

  • 39.

    Fogo AB , Lusco MA , Najafian B , Alpers CE : AJKD atlas of renal pathology: Light chain proximal tubulopathy. Am J Kidney Dis 67: e9–e10, 2016 PubMed

  • 40.

    Cheng M , Gu X , Turbat-Herrera EA , Herrera GA : Tubular injury and dendritic cell activation are integral components of light chain-associated acute tubulointerstitial nephritis. Arch Pathol Lab Med 143: 1212–1224, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 41.

    Fogo AB , Lusco MA , Najafian B , Alpers CE : AJKD atlas of renal pathology: Immunotactoid glomerulopathy. Am J Kidney Dis 66: e29–e30, 2015 PubMed

  • 42.

    Karasawa K , Uchida K , Nakano T , Moriyama T , Nitta K : Successful treatment with rituximab of immunotactoid glomerulopathy exhibiting nephrotic syndrome. Clin Nephrol 90: 222–226, 2018 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 43.

    Ohashi A , Kumagai J , Nagahama K , Fujisawa H : Case of immunotactoid glomerulopathy showing high responsiveness to steroids therapy despite severe pathological features. BMJ Case Rep 12: e229751, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 44.

    Kousios A , Duncan N , Charif R , Tam FWK , Levy J , Cook HT , et al.: Autologous stem cell transplant for the treatment of type i crystal cryoglobulinemic glomerulonephritis caused by monoclonal gammopathy of renal significance (MGRS). Kidney Int Rep 4: 1342–1348, 2019 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 45.

    Singh M , Jackson KJL , Wang JJ , Schofield P , Field MA , Koppstein D , et al..: Lymphoma driver mutations in the pathogenic evolution of an iconic human autoantibody. Cell 180: 878–894, 2020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 46.

    Jadoul M , Berenguer MC , Doss W , Fabrizi F , Izopet J , Jha V , et al.: Executive summary of the 2018 KDIGO Hepatitis C in CKD Guideline: Welcoming advances in evaluation and management. Kidney Int 94: 663–673, 2018 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 47.

    Nasr SH , Markowitz GS , Stokes MB , Seshan SV , Valderrama E , Appel GB , et al.: Proliferative glomerulonephritis with monoclonal IgG deposits: A distinct entity mimicking immune-complex glomerulonephritis. Kidney Int 65: 85–96, 2004 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 48.

    Nasr SH , Satoskar A , Markowitz GS , Valeri AM , Appel GB , Stokes MB , et al.: Proliferative glomerulonephritis with monoclonal IgG deposits. J Am Soc Nephrol 20: 2055–2064, 2009 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 49.

    Bhutani G , Nasr SH , Said SM , Sethi S , Fervenza FC , Morice WG , et al.: Hematologic characteristics of proliferative glomerulonephritides with nonorganized monoclonal immunoglobulin deposits. Mayo Clin Proc 90: 587–596, 2015 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 50.

    Fermand JP , Bridoux F , Kyle RA , Kastritis E , Weiss BM , Cook MA , et al.; International Kidney and Monoclonal Gammopathy Research Group: How I treat monoclonal gammopathy of renal significance (MGRS). Blood 122: 3583–3590, 2013 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 51.

    Gumber R , Cohen JB , Palmer MB , Kobrin SM , Vogl DT , Wasserstein AG , et al.: A clone-directed approach may improve diagnosis and treatment of proliferative glomerulonephritis with monoclonal immunoglobulin deposits. Kidney Int 94: 199–205, 2018 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 52.

    Kamal J , Khairallah P , Crew RJ , Ye X , Swanson SJ , Kudose S , et al.: Clinicopathologic assessment of monoclonal immunoglobulin-associated renal disease in the kidney allograft: A retrospective study and review of the literature. Transplantation 104: 1341–1349, 2020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 53.

    Best Rocha A , Larsen CP : Membranous glomerulopathy with light chain-restricted deposits: A clinicopathological analysis of 28 cases. Kidney Int Rep 2: 1141–1148, 2017 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 54.

    Larsen CP , Ambuzs JM , Bonsib SM , Boils CL , Cossey LN , Messias NC , et al.: Membranous-like glomerulopathy with masked IgG kappa deposits. Kidney Int 86: 154–161, 2014 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 55.

    Larsen CP , Boils CL , Cossey LN , Sharma SG , Walker PD : Clinicopathologic features of membranous-like glomerulopathy with masked IgG kappa deposits. Kidney Int Rep 1: 299–305, 2016 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 56.

    Larsen CP , Sharma SG , Caza TN , Kenan DJ , Storey AJ , Edmondson RD , et al.: Serum amyloid P deposition is a sensitive and specific feature of membranous-like glomerulopathy with masked IgG kappa deposits. Kidney Int 97: 602–608, 2020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 57.

    Andeen NK , Yang HY , Dai DF , MacCoss MJ , Smith KD : DnaJ homolog subfamily B member 9 is a putative autoantigen in fibrillary GN. J Am Soc Nephrol 29: 231–239, 2018 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 58.

    Dasari S , Alexander MP , Vrana JA , Theis JD , Mills JR , Negron V , et al.: DnaJ heat shock protein family B member 9 is a novel biomarker for fibrillary gn. J Am Soc Nephrol 29: 51–56, 2018 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 59.

    Said SM , Leung N , Alexander MP , Cornell LD , Fidler ME , Grande JP , et al.: DNAJB9-positive monotypic fibrillary glomerulonephritis is not associated with monoclonal gammopathy in the vast majority of patients. Kidney Int 98: 498–504, 2020 PubMed

    • PubMed
    • Search Google Scholar
    • Export Citation

Metrics

All Time Past Year Past 30 Days
Abstract Views 25377 24404 1496
Full Text Views 581 126 21
PDF Downloads 833 175 26